■越来越多的证据表明，Th1/Th2相关细胞因子基因中的单核苷酸多态性（SNP）与口腔扁平苔藓（OLP）易感性相关。然而,这些结果不一致且无定论.因此，本研究的目的是对6种细胞因子（IFN-γ，IL-18,TGFβ1,IL-1β,IL-2、IL-4)和OLP。
■进行了系统的文献检索，以确定有关6种细胞因子中SNP与OLP易感性之间关联的所有合格病例对照研究。将来自每个研究的赔率比(ORs)和95%置信区间(CIs)合并以估计关联的强度。
■发现IFN-γ（874A/T）多态性与OLP的显着关联（OR，1.49；95CI，1.22-1.81；P<0.001），基于6项符合条件的研究。发现IL-18(137G/C)多态性与OLP显著相关(OR,1.64；95CI，1.24-2.18；P<0.001）基于3项研究。发现等位基因模型中TGFβ1（509C/T）多态性与OLP的相关性（OR，1.31；95CI，1.01-1.71；P=0.05），基于4项研究。然而，缺乏IL-1β（3954C/T）的显著关联，IL-2(330T/G),IL-4（590C/T），3项研究发现IL-18(607C/A)多态性与OLP相关(P>0.05),分别。
■这是第一个研究6种细胞因子多态性与OLP的关系的荟萃分析，表明IFN-γ中的SNP，IL-18和TGFβ1可能是OLP风险的遗传因素。需要进一步精心设计的具有更大样本量和多种族的研究来验证这些关联。
UNASSIGNED: Increasing evidence suggests that single-nucleotide polymorphisms (SNPs) in Th1/Th2-related cytokine genes correlated with oral lichen planus (OLP) susceptibility. However, these results were inconsistent and inconclusive. Hence, the aim of this study is to draw a more precise estimation of the genetic associations between SNPs in 6 cytokines (IFN-γ, IL-18, TGFβ1, IL-1β, IL-2, IL-4) and OLP.
UNASSIGNED: A systematic literature search was conducted to identify all eligible
case-control studies on the association between SNPs in 6 cytokines and OLP susceptibility. Odds ratios (ORs) and 95% confidence intervals (CIs) from each study were pooled to estimate the strength of the association.
UNASSIGNED: A significant association of IFN-γ (874A/T) polymorphism with OLP was found (OR, 1.49; 95%CI, 1.22-1.81; P < 0.001) based on 6 eligible studies. A significant association of IL-18 (137G/C) polymorphism with OLP was found (OR, 1.64; 95%CI, 1.24-2.18; P < 0.001) based on 3 studies. A marginally significant association of TGFβ1 (509C/T) polymorphism in allele model with OLP was found (OR, 1.31; 95%CI, 1.01-1.71; P = 0.05) based on 4 studies. Nevertheless, lack of significant association of IL-1β (3954C/T), IL-2 (330T/G), IL-4 (590C/T), and IL-18 (607C/A) polymorphisms with OLP was found (P > 0.05) based on 3 studies, respectively.
UNASSIGNED: This is the first meta-analysis to investigate the associations of 6 cytokines polymorphisms with OLP, suggesting that SNPs in IFN-γ, IL-18, and TGFβ1 may act as genetic factors for OLP risk. Further well-designed studies with larger sample size and multiple ethnicities are needed to validate these associations.
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