许多生物制剂现在由患者在家中自行管理。各种自注射装置是可用的,包括小瓶和注射器,预充式注射器,和弹簧驱动的预填充笔或自动注射器。每个都有优点和缺点,不同的设备适合不同的患者。例如,一些患者很难实现一致和成功的自我注射由于差的手灵活性,或在自我注射或注射部位疼痛时感到焦虑。这些因素会降低患者的用药依从性和整体体验。此外,虽然自我注射给患者带来了许多好处,一次性注射装置的激增对环境可持续性有影响,包括对一次性塑料的依赖,重复的货运要求,并需要焚烧作为危险废物。最近开发的,创新的机电自动注射器装置提供技术增强现有的设备,以克服这些问题中的一些。功能包括可定制的注射速度或持续时间,一致的注射速度,电子注射日志和提醒,一步一步地,实时指令。的确,越来越多的证据表明,与其他器械相比,使用机电器械的患者的依从率更高.Further,随着时间,与一次性设备相比,机电设备的可重用性可能会减轻对环境的影响,特别是随着研究继续优化其可持续性,受消费者对环境责任要求增加的驱动。这篇叙述性综述讨论了预充式注射器之间的差异,弹簧驱动的预填充笔,和机电设备。它还探讨了这些功能如何帮助减少与注射相关的疼痛和焦虑,改善患者体验,连通性和依从性,并推动未来生物药物的可持续性。
生物制品是一种在许多不同疾病的治疗中变得普遍的药物。生物制品在皮下注射,有时可以由患者自己在家注射。许多注射装置可用于帮助患者进行自我注射,分为三大类:预充式注射器,预填充笔,和机电设备。每个人都有自己的优点和缺点,不同的设备适合不同的患者。例如,一些患者由于手部活动受限或对自我注射或注射部位疼痛的前景感到焦虑,难以获得一致和成功的自我注射.这些因素会降低患者按规定服药的能力和意愿,并可能恶化他们的整体体验。Further,许多一次性设备涉及一次性塑料,可能会造成环境损失。可重复使用的机电设备是最新的可用设备,并且提供了比一些早期设备增强的功能。这些包括可定制的注射速度或持续时间,一致的注射速率,电子注射日志,提醒,和实时指令。有证据表明,使用机电设备的患者可能比使用其他设备的患者具有更高的依从性(即更多的患者按照处方服用药物)。此外,随着时间和进一步的研究,与一次性设备相比,机电设备的可重用性可能会减轻对环境的影响。在这里,我们讨论预填充笔之间的区别,预充式注射器,和机电设备,并探索可能有助于减少注射相关疼痛和焦虑的特征,改善患者体验,连通性,和坚持,推动更大的可持续性。
Many biologics are now self-administered by patients at home. A variety of self-injection devices are available, including vials and
syringes, prefilled
syringes, and spring-driven prefilled pens or auto-injectors. Each has advantages and drawbacks, and different devices suit different patients. For example, some patients have difficulty achieving consistent and successful self-injection due to poor manual dexterity, or experience anxiety at the prospect of self-injection or injection-site pain. These factors can reduce patients\' medication adherence and overall experience. Furthermore, while self-injection brings patients many benefits, the proliferation of single-use injection devices has implications for environmental sustainability, including the reliance on single-use plastics, repeated freighting requirements, and need for incineration as hazardous waste. Recently developed, innovative electromechanical auto-injector devices offer technological enhancements over existing devices to overcome some of these issues. Features include customisable injection speeds or durations, consistent rate of injection, electronic injection logs and reminders, and step-by-step, real-time instructions. Indeed, a growing body of evidence points to higher adherence rates among patients using electromechanical devices compared with other devices. Further, with time, the reusability of electromechanical devices may prove to lighten the environmental impact compared with disposable devices, especially as research continues to optimise their sustainability, driven by increased consumer demands for environmental responsibility. This narrative
review discusses the differences between prefilled
syringes, spring-driven prefilled pens, and electromechanical devices. It also explores how these features may help reduce injection-associated pain and anxiety, improve patient experience, connectivity and adherence, and drive sustainability of biologic drugs in future.
Biologics are a type of medicine becoming widespread in the treatment of many diverse diseases. Biologics are injected under the skin and can sometimes be injected by patients themselves at home. Many injection devices are available to help patients with this self-injection, and fall into three broad categories: prefilled
syringes, prefilled pens, and electromechanical devices. Each has its own advantages and disadvantages, and different devices suit different patients. For example, some patients have difficulty achieving consistent and successful self-injection because of limited hand movement or become anxious at the prospect of self-injection or injection-site pain. These factors can reduce patients’ ability and willingness to take medication as prescribed and may worsen their overall experience. Further, many disposable devices involve single-use plastics and may pose an environmental toll. Reusable electromechanical devices are the newest of the available devices and offer enhanced features over some earlier devices. These include customisable injection speeds or durations, consistent rates of injection, electronic injection logs, reminders, and real-time instructions. Evidence suggests that patients using electromechanical devices may have higher rates of adherence (i.e. more patients take their medication as prescribed) than those using other devices. Additionally, with time and further research, the reusability of electromechanical devices may prove to lighten the environmental impact compared with disposable devices. Here we discuss the differences between prefilled pens, prefilled
syringes, and electromechanical devices, and explore the features that may help reduce injection-associated pain and anxiety, improve patient experience, connectivity, and adherence, and drive greater sustainability.