目的:通过测量C反应蛋白(CRP),光生物调节疗法(PBMT)对TPLO术后CCLR患者的影响,承重百分比,使用复合疼痛量表的简短形式,由临床医生和业主评估,和手术部位感染。
方法:本研究在2021年4月5日至2022年4月10日之间招募了54只接受单侧TPLO手术的CLR患者犬。
方法:将研究群体随机分配到接受PMBT的治疗组(24只狗)或对照组(30只狗)。诱导后立即对治疗组进行PMBT,6小时,24小时,48小时,术后8周。对照组同时接受假PMBT(设备关闭)。CRP的评价,CMPS-SF,SSI的证据,术前24小时对所有狗进行了WB和%评估,然后24小时,48小时,术后8周。术后8周,业主每周完成CMPS-SF和主观评价。
结果:在评估CRP时,治疗组之间无统计学差异,%WB,临床医生和CMPS-SF,业主每周评估CMPS-SF。尽管在治疗组之间发生手术部位感染的患者中没有发现统计学上的显着差异,仅在对照组患者中观察到SSI(5/30,16.6%)。大多数是轻微/浅表感染(4/3013.3%),单只狗(1/30,3.3%)有重大/深部手术部位感染。
结论:虽然两组间有希望但无统计学意义的差异,手术部位感染可在PBMT应用后减少。
OBJECTIVE: Effect of photobiomodulation therapy (PBMT) in patients with CCLR after TPLO surgery by measuring C-reactive protein (CRP), percentage weight bearing, lameness using a short form of a composite measure pain scale, evaluated by the clinician and owners, and surgical site infection.
METHODS: 54 client-owned dogs with CCLR undergoing unilateral TPLO surgery were enrolled in this
study between April 5, 2021, through April 10, 2022.
METHODS: The
study population was randomly assigned to either a treatment group receiving PMBT (24 dogs) or a control group (30 dogs). PMBT was performed on the treatment group immediately after induction, and 6 hours, 24 hours, 48 hours, and 8 weeks postoperatively. The control group received sham PMBT (device turned off) at the same time. Evaluation of CRP, CMPS-SF, evidence of SSI, and %WB were evaluated for all dogs 24 hours preoperatively, and then 24 hours, 48 hours, and 8 weeks postoperatively. Owners completed CMPS-SF and subjective evaluations weekly for 8 weeks postoperatively.
RESULTS: No statistically significant differences were found between treatment groups when evaluating CRP, %WB, and CMPS-SF by the clinician and weekly evaluation of the CMPS-SF by owners. Although no statistically significant differences were found in patients developing surgical site infections between treatment groups, SSI was only observed in patients in the control group (5/30, 16.6%). Most were minor/superficial infections (4/30 13.3%), and a single dog (1/30, 3.3%) had a major/deep surgical site infection.
CONCLUSIONS: Although with promising but not statistically significant differences between groups, surgical site infections may be reduced after PBMT application.