外阴上皮内瘤变(VIN)是外阴表皮的癌前病变,不会侵入或转移到周围基质;它表现为外阴不典型的上皮内增生。大多数VIN患者早期诊断,标准化治疗通常会导致症状完全消退。VIN的治疗对于临床医生来说仍然是一个挑战,在大多数情况下,手术具有破坏性和危险性。然而,光动力疗法(PDT)被推荐为VIN的新治疗方法.在这里,我们报告一例大面积高级别VIN病变并发人乳头瘤病毒感染的患者.患者无法接受手术治疗。然而,我们在门诊部进行了PDT治疗.多点注射微量利多卡因(0.05mL/dot)后,治疗期间出现轻微疼痛。随访13个月后无复发。更重要的是,未检测到瘢痕形成和其他主要副作用。因此,对于具有大病灶或多灶性高级别VIN的VIN患者,PDT可以是有用的替代治疗。
Vulvar intraepithelial neoplasia (VIN) is a precancerous lesion on the vulvar epidermis that does not invade or metastasize to surrounding stroma; it manifests as atypical intraepithelial hyperplasia on the vulva. Most patients with VIN are diagnosed early, and treatment with standardized therapy often leads to complete regression of symptoms. The treatment of VIN is still a challenge for clinicians because, in most cases, surgery is destructive and risky. However, photodynamic therapy (PDT) was recommended as a new treatment for VIN. Herein, we report the
case of a patient with a large-area high-grade VIN lesion complicated by human papillomavirus infection. The patient could not undergo surgical treatment. However, treatment with PDT was performed in our outpatient department. There was slight pain during the treatment after multi-point injection of micro-lidocaine (0.05 mL/dot) was given. No recurrence was noted after 13 months of follow-up. More importantly, scarring and other major side effects were not detected. Therefore, PDT can be a useful alternative treatment for patients with VIN with large lesions or multifocal high-grade VIN.