姜黄素对神经精神疾病有保护作用,作为神经保护剂.作为第一种方法,本研究旨在系统评价姜黄素对注意缺陷多动障碍(ADHD)认知能力的潜在影响.这项研究是在PubMed的数据库中进行的,Embase,SciELO,Cochrane中央控制试验登记册(CENTRAL),WebofScience,和灰色文学。在发现相关研究的稀缺性后,知道姜黄素可能有多动症和焦虑行为,本研究旨在评价姜黄素对自发性高血压Wistar大鼠(SHR)ADHD表型的影响.没有发现与姜黄素和ADHD相关的研究。然后将15个SHR分为接受水(1mg/kg/天)的单独组,姜黄素(50毫克/千克/天),或哌醋甲酯(1mg/kg/天),持续42天。评估活动的行为测试(开放式测试),焦虑和冲动(高架+迷宫,和社交互动),和记忆(Y-迷宫,和对象识别测试)全部进行。用姜黄素治疗的动物表现出较少的焦虑和过度活跃行为,如开放领域测试和社交互动测试所示。通过EPM测量焦虑行为,并且不通过任何处理来调节。Y-迷宫测试的结果表明姜黄素改善了空间记忆。在对象识别测试中,短期记忆和长期记忆都没有改善。本研究中使用的治疗有益地调节了SHR的焦虑和过度活跃行为。
Curcumin has protective actions in neuropsychiatric disorders, acting as a neuroprotective agent. As a first approach, the study aimed at a systematic
review of the potential effects of curcumin on cognitive performance for attention-deficit-hyperactivity disorder (ADHD). This research was carried out in the databases of PubMed, Embase, SciELO, the Cochrane Central Register of Controlled Trials (CENTRAL), the Web of Science, and the Grey literature. Upon discovering the scarcity of relevant studies, and knowing that curcumin might have an ADHD hyperactive and anxious behavior, the study proposed to evaluate the effects of curcumin in an ADHD phenotype of spontaneously hypertensive Wistar rats (SHR). No studies were found that related to curcumin and ADHD. Fifteen SHRs were then divided into separate groups that received water (1 mg/kg/day), curcumin (50 mg/kg/day), or methylphenidate (1 mg/kg/day) for 42 days. Behavioral tests to assess activity (Open Field Test), anxiety and impulsivity (Elevated Plus-Maze, and Social Interaction), and memory (Y-Maze, and the Object Recognition Test) were all performed. The animals that were treated with curcumin showed less anxious and hyperactive behavior, as seen in the Open Field Test and the Social Interaction Test. Anxious behavior was measured by the EPM and was not modulated by any treatment. The results of the Y-Maze Test demonstrated that curcumin improved spatial memory. In the Object Recognition Test, neither the short nor the long-term memory was improved. The treatments that were used in this study beneficially modulated the anxious and hyperactive behavior of the SHR.