总结目前可用的I期和II期临床试验nonoxynol-9(N-9)对人精子结构和功能的影响。
旨在评估N-9对运动性的杀精子活性的系统评价和荟萃分析,是在PubMed中进行的,EMBASE,和Cochrane数据库到2021年3月10日。分析了宫颈粘液中进行性活动(PR)精子的计数数量和先锋精子穿透距离。还综述了对精子结构和生理活动的其他影响。
在汇总结果中,N-9处理后PR精子的百分比或计数减少。治疗组先锋精子穿透距离缩短。N-9已被证实会破坏精子的结构,以及其他细胞器,如顶体和线粒体。生理活动,如产生活性氧,超氧化物歧化酶活性,顶蛋白酶活性,在综述的研究中,hemizona结合均受到抑制。
N-9对精子有几个影响,因为它能降低精子活力和宫颈粘液渗透,以及其他职能能力。
Nonoxynol-9(N-9)已在全球范围内用作杀精子剂杀死精子超过60年,但可引起包括阴道刺激在内的副作用,并可增加避孕失败率。对旨在评估N-9对精子的杀精活性的已发表文献进行了详细分析。在汇总结果中,N-9减少了活跃精子的数量和它们行进的距离。它还对精子的结构以及精子与卵子的作用和相互作用方式造成了损害。总之,N-9以多种方式影响精子,导致精子死亡和功能障碍。
To summarize the currently available phase I and II clinical trials of the effects of nonoxynol-9 (N-9) on human sperm structure and functions.
A systematic
review and meta-analysis aiming to evaluate the spermicidal activity of N-9 on motility, was conducted in PubMed, EMBASE, and Cochrane databases by 10 March 2021. The counted numbers of progressive motile (PR) sperm in cervical mucus and the vanguard sperm penetration distances were analyzed. Other effects on sperm structures and physiological activities were reviewed as well.
In the pooled results, percentages or counted numbers of PR sperm decreased after the treatment of N-9. Vanguard sperm penetration distance was shortened in treated groups. N-9 has been confirmed to damage the structures of sperm, as well as other organelles like acrosome and mitochondria. The physiological activities such as generation of reactive oxygen species, superoxide dismutase activity, acrosin activity, and hemizona binding were all inhibited in the reviewed studies.
N-9 has several impacts on sperm owing to its potency in reducing sperm motility and cervical mucus penetration, as well as other functional competencies.
Nonoxynol-9 (N-9) has been used worldwide as a spermicide to kill sperm for more than 60 years but can cause side effects including vaginal irritation and can increase the rate of contraceptive failure. A detailed analysis of published literature aiming to evaluate the spermicidal activity of N-9 on sperm was carried out. In the pooled results, N-9 reduced the number of active sperm and the distance they traveled. It also caused damage to the structures of sperm and to the way the sperm acted and interacted with the egg. In conclusion, N-9 impacts on sperm in a number of ways that lead to sperm death and dysfunction.