骨关节炎(OA)是一种退行性疾病,目前还没有有效的药物来治愈它。早期预防和治疗可有效减轻OA患者的痛苦,节约费用。因此,早期诊断OA是必要的。OA有多种诊断方法,但应用于早期诊断的方法有限。普通的光学诊断局限于表面,而实验室测试,如类风湿因子检查和物理关节炎检查,太琐碎或耗时。显然,迫切需要开发一种快速无损检测方法,用于OA的早期诊断。振动光谱学是一种快速、无损的技术,备受关注。在这次审查中,近红外(NIR),红外线,介绍了(IR)和拉曼光谱,以显示它们在早期OA诊断中的潜力。首先讨论了基本原理,然后讨论了迄今为止的研究进展,以及其局限性和发展方向。最后,对所有方法进行了比较,和振动光谱学证明它可以用作早期OA诊断的有希望的工具。本综述为振动光谱技术在OA诊断中的应用和发展提供了理论支持,为关节炎的无损快速诊断提供了新的策略,促进了基于组分的分子谱检测技术的发展和临床应用。
Osteoarthritis (OA) is a degenerative disease, and there is currently no effective medicine to cure it. Early prevention and treatment can effectively reduce the pain of OA patients and save costs. Therefore, it is necessary to diagnose OA at an early stage. There are various diagnostic methods for OA, but the methods applied to early diagnosis are limited. Ordinary optical diagnosis is confined to the surface, while laboratory tests, such as rheumatoid factor inspection and physical arthritis checks, are too trivial or time-consuming. Evidently, there is an urgent need to develop a rapid nondestructive detection method for the early diagnosis of OA. Vibrational spectroscopy is a rapid and nondestructive technique that has attracted much attention. In this
review, near-infrared (NIR), infrared, (IR) and Raman spectroscopy were introduced to show their potential in early OA diagnosis. The basic principles were discussed first, and then the research progress to date was discussed, as well as its limitations and the direction of development. Finally, all methods were compared, and vibrational spectroscopy was demonstrated that it could be used as a promising tool for early OA diagnosis. This
review provides theoretical support for the application and development of vibrational spectroscopy technology in OA diagnosis, providing a new strategy for the nondestructive and rapid diagnosis of arthritis and promoting the development and clinical application of a component-based molecular spectrum detection technology.