细菌性食源性病原体(FBP)是世界范围内食源性疾病或食源性疾病(FBD)的最常见原因。它们在整个食物链的任何阶段污染食物,从农场到餐桌。其中,腹泻性大肠杆菌(DEC),非伤寒沙门氏菌(NTS),志贺氏菌属。和弯曲杆菌。是造成很大一部分疾病的原因,死亡;和,特别是,作为急性腹泻病的病因。尽管现有研究表明,在埃塞俄比亚等发展中国家,这一问题可能很严重,证据通常基于个别研究的零散数据.对已发表和未发表的手稿进行了审查,以获取有关主要FBP的信息,并确定在跟踪其来源归因方面的差距,动物和环境界面。在将研究期限限制在2000年1月至2020年7月之后,最初共检索了1753篇文章。第二次筛选后,本综述仅包括51篇关于人类的文章和43篇基于环境样本的研究。在没有分组的情况下,我们分析了基于总体以及人类粪便和环境样本的FBP汇总患病率估计值.因为,预计会有很大的异质性,我们还对主要研究变量进行了亚组分析,以估计两种样本来源中不同流行病学环境下FBP的汇总患病率.FBP(沙门氏菌,致病性大肠杆菌(E.大肠杆菌),志贺氏菌和弯曲杆菌属。)为8%;95%CI:6.5-8.7,在环境样本(11%)中的估计值(P<0.01)高于人类粪便(6%)。亚组分析表明,沙门氏菌和致病性大肠杆菌分别占5.7%(95%CI:4.7-6.8)和11.6%(95%CI:8.8-15.1),埃塞俄比亚FBD总体汇总患病率估计。元回归结果显示,行政区国家,研究的地理区域,样本来源和分类样本量均显著影响沙门氏菌和致病性大肠杆菌的异质性。此外,多变量回归显示,2011年至2015年的实际研究年与基于环境样本的FBP患病率估计值显著相关.这项系统评价和荟萃分析描述了FBP在埃塞俄比亚很重要,尽管大多数研究是在人类中单独进行的,采用基于常规培养的诊断方法的动物或环境样品。因此,在人类的FBD进一步研究,需要采用先进的诊断方法来研究一种健康方法中FBD的来源归因。
Bacterial Foodborne Pathogens (FBP) are the commonest cause of foodborne illness or foodborne diseases (FBD) worldwide. They contaminate food at any stages in the entire food chain, from farm to dining-table. Among these, the Diarrheagenic Escherichia coli (DEC), Non typhoidal Salmonella (NTS), Shigella spp. and Campylobacter spp. are responsible for a large proportion of illnesses, deaths; and, particularly, as causes of acute diarrheal diseases. Though existing studies indicate the problem may be severe in developing countries like Ethiopia, the evidence is commonly based on fragmented data from individual studies. A
review of published and unpublished manuscripts was conducted to obtain information on major FBP and identify the gaps in tracking their source attributions at the human, animal and environmental interface. A total of 1753 articles were initially retrieved after restricting the study period to between January 2000 and July 2020. After the second screening, only 51 articles on the humans and 43 on the environmental sample based studies were included in this
review. In the absence of subgroups, overall as well as human stool and environmental sample based pooled prevalence estimate of FBP were analyzed. Since, substantial heterogeneity is expected, we also performed a subgroup analyses for principal study variables to estimate pooled prevalence of FBP at different epidemiological settings in both sample sources. The overall random pooled prevalence estimate of FBP (Salmonella, pathogenic Escherichia coli (E. coli), Shigella and Campylobacter spp.) was 8%; 95% CI: 6.5-8.7, with statistically higher (P < 0.01) estimates in environmental samples (11%) than in human stool (6%). The subgroup analysis depicted that Salmonella and pathogenic E. coli contributed to 5.7% (95% CI: 4.7-6.8) and 11.6% (95% CI: 8.8-15.1) respectively, of the overall pooled prevalence estimates of FBD in Ethiopia. The result of meta-regression showed, administrative regional state, geographic area of the study, source of sample and categorized sample size all significantly contributed to the heterogeneity of Salmonella and pathogenic E. coli estimates. Besides, the multivariate meta- regression indicated the actual study year between 2011 and 2015 was significantly associated with the environmental sample-based prevalence estimates of these FBP. This systematic
review and meta-analysis depicted FBP are important in Ethiopia though majority of the studies were conducted separately either in human, animal or environmental samples employing routine culture based diagnostic method. Thus, further FBD study at the human, animal and environmental interface employing advanced diagnostic methods is needed to investigate source attributions of FBD in one health approach.