■广泛国家的监测系统是消除碘缺乏病(IDD)的显着努力。这项研究旨在收集有关食盐中碘化物含量的数据,以及家庭消费模式如何影响儿童的碘状况及其对其生长的影响。
■设计了单治疗臂社区试验研究设计。从分配干预或控制的地区随机选择较低的社区单位(LCU)。从LCU列表中,随机选择了834名母亲及其配对的孩子。在国家食品和营养实验室收集并检查了尿液和食盐样品。使用t检验确定臂之间的差异,并采用广义估计方程(GEE)对参数进行预测。
■164个食盐样品中的平均碘化物含量(98.1%)为45.3ppm,标准偏差(SD)为14.87,其高于或等于推荐的百万分率(ppm)。在基线调查和终线调查之间,平均尿碘浓度(UIC)为107.7µg/L(+/-8.64SD)和260.9µg/L(+/-149SD).儿童尿碘排泄(UIE)有127(15.2%)儿童碘不足的研究开始时,但干预组最后只有11人(2.6%)的碘不足.儿童的平均身高(Ht)在基线时为83.1cm(+/-10SD),在调查结束时为136.4cm(+/-14SD)。母亲知道很多(72%)在烹饪结束时在食物中添加碘盐,其中183人(21.9%)定期和有目的地这样做。干预组40.5%的儿童在基线时发育迟缓,在研究结束时下降到15.1%,但在对照组中上升到51.1%。干预组和对照组之间尿碘浓度(UIC)的平均差异(MD)为97.56µg/L,标准误差(SE)为9.83(p=0.001)。干预组患儿终线Ht较对照组增加7.93cm(β=7.93,p=0.005)。
我们的研究表明,拥有健康饮食习惯的母亲在碘状况和孩子的身高增长方面都有改善。除了管理和使用碘盐,它还引入了其他健康饮食习惯的选择,这也将在孩子的未来发展中发挥重要作用。这种知识转移干预对于社会健康的可持续性至关重要。因此,这项试验的意义表明,干预组的碘状况和生长可以得到基本改善,而对照组继续经历负面影响。
■ClinicalTrials.gov标识符:NCT0484601.
UNASSIGNED: Monitoring systems in a broad range of countries are a notable effort to eliminate iodine deficiency disorders (IDDs). This
study aimed to gather data on the amount of iodide present in table salt and how household consumption patterns affect children\'s iodine status and its effect on their growth.
UNASSIGNED: A single treatment arm community
trial study design was designed. Lower community units (LCUs) were chosen at random from districts assigned either intervention or control. From a list of LCUs, 834 mothers and their paired children were chosen randomly. Urine and table salt samples were collected and examined in the national food and nutrition laboratory. The deference between arms was determined using a t test, and the generalized estimating equation (GEE) was used to forecast parameters.
UNASSIGNED: The mean iodide content in the table salt samples of 164 (98.1%) was 45.3 ppm and a standard deviation (SD) of 14.87, which were above or equal to the recommended parts per million (ppm). Between the baseline survey and the end-line survey, the mean urine iodine concentration (UIC) was 107.7 µg/L (+/- 8.64 SD) and 260.9 µg/L (+/- 149 SD). Children\'s urine iodine excretion (UIE) had inadequate iodine in 127 (15.2%) children at the beginning of the
study, but only 11 (2.6%) of the intervention group still had inadequate iodine at the end. The childrens\' mean height (Ht) was 83.1 cm (+/-10 SD) at baseline and 136.4 cm (+/-14 SD) at the end of the survey. Mothers knew a lot (72%) about adding iodized salt to food at the end of cooking, and 183 (21.9%) of them did so regularly and purposefully. A total of 40.5% of children in the intervention group had stunted growth at baseline, which decreased to 15.1% at the end of the
study but increased in the control group to 51.1%. The mean difference (MD) of urine iodine concentration (UIC) between intervention and control groups was 97.56 µg/L, with a standard error (SE) of 9.83 (p = 0.001). The end-line Ht of children in the intervention group was increased by 7.93 cm (β = 7.93, p = 0.005) compared to the control group.
UNASSIGNED: Our research has shown that mothers who embraced healthy eating habits had perceived improvements in both the iodine status and height growth of their children. In addition to managing and using iodine salt, it has also introduced options for other healthy eating habits that will also play a significant role in their children\'s future development. This sort of knowledge transfer intervention is essential for the sustainability of society\'s health. Therefore, this
trial\'s implications revealed that the intervention group\'s iodine status and growth could essentially be improved while the control group continued to experience negative effects.
UNASSIGNED: ClinicalTrials.gov Identifier: NCT048460 1.