背景:外用皮质类固醇是治疗皮肤炎症的最常用处方药,但是它们的使用会导致一些不良影响。如今,已经评估了新的药理学策略,以提高皮肤病疗效并减少不良反应,包括天然产品。
目的:这项研究的目的是评估和比较植物甾醇标准化超临界CO2植物药物与氢化可的松对免疫和炎症介质的影响,和皮肤修复组件生产。此外,我们在一项双盲安慰剂对照临床试验中研究了两种产品对皮肤微循环和体温的影响.
方法:两种产品均进行了免疫评估(IL-6,IL-10,INF-γ,TNF-α,和IL-1α),炎症(COX-2,LOX,PLA2,PGE2,LTB4,组胺,和NF-κB),和修复成分(TGF-β,GM-CSF,胶原蛋白,和GAG)在非刺激和LPS刺激条件下在人角质形成细胞和成纤维细胞上的生产。的确,在一项随机双盲安慰剂对照临床试验中,我们使用激光多普勒和红外温度计评估了两种面霜对皮肤微循环和温度的影响,分别。
结果:酸浆作用于皮肤,调节免疫状态和炎症反应产生类皮质激素作用,但与氢化可的松不同,增加皮肤修复因子。在临床试验中,植物药物乳膏的作用比氢化可的松更好地降低了皮肤微循环和温度。
结论:综合来看,结果表明,甾醇标准化CO2超临界制剂是一种具有多种药理作用的新型创新植物药物,可作为人体皮肤保护产品,特别是针对皮肤炎症性疾病。
BACKGROUND: Topical corticosteroids have been the most commonly prescribed drugs to treat skin inflammation, but their uses can lead to several adverse effects. Nowadays, new pharmacological strategies have been evaluated to improve dermatologic efficacy and reduce adverse effects, including natural products.
OBJECTIVE: The aim of this
study was to evaluate and compare the effects of a plant sterol standardized supercritical CO2 phytopharmaceutical of Physalis angulata L. with hydrocortisone on the immune and inflammatory mediators, and skin repair components production. Moreover, we studied effects of both products on the skin microcirculation and temperature in a double-blind placebo-controlled clinical
trial.
METHODS: Both products were evaluated on the immune (IL-6, IL-10, INF-γ, TNF-α, and IL-1α), inflammatory (COX-2, LOX, PLA2 , PGE2 , LTB4 , histamine, and NF-κB), and repair components (TGF-β, GM-CSF, collagen, and GAG) production on human keratinocytes and fibroblast in non-stimulated and LPS-stimulated conditions. Indeed, in a randomized double-blind placebo-controlled clinical
trial, we evaluated the effects of the both creams on the skin microcirculation and temperature using laser Doppler and infrared thermometer, respectively.
RESULTS: Physalis angulata acted on the skin, modulating immune status and inflammatory response producing corticoid-like effects, but different of hydrocortisone, increased skin repair factors. The effects of phytopharmaceutical cream in the clinical
trial promoted a better reduction in skin microcirculation and temperature than hydrocortisone.
CONCLUSIONS: Taken together, the results indicate that sterol standardized CO2 supercritical preparation of P angulata is a new and innovative phytopharmaceutical with multiple pharmacological effects potentially useful as human skin protective product, particularly against cutaneous inflammatory disorders.