目的:本报告的目的是介绍一例患者,金属铸造工人,已经接触过20多年的工业银盐。众所周知,长期接触银化合物会导致各种组织中银沉积物的积累。这种情况被称为argyyrosis或argyria,而与眼组织相关的变化被定义为眼甲状腺素。
方法:完整的眼部检查,角膜共聚焦显微镜,动态和静态视野测试,后段光学相干断层扫描,图形视觉诱发电位(PVEP),闪光视觉诱发电位,多焦视网膜电图,模式视网膜电图(PERG),均进行了全视野视网膜电图(FERG)和眼电图检查.
结果:眼部检查显示视力下降,角膜沉积和黄斑内的神经囊膜样变化。尽管电生理测试没有显示视网膜色素上皮细胞功能的变化,他们揭示了中央和周边视网膜的光感受器功能异常。PERG异常和PVEP中P100波的延迟潜伏期证实了黄斑区视网膜内层的功能受损。
结论:角膜共聚焦显微镜和电生理检查可能有助于确定眼甲状腺素的诊断。
OBJECTIVE: The aim of this report is to present a
case of a patient, metal foundry worker, who had been exposed to industrial silver salts for over 20 years. It is well established that chronic exposure to silver compounds can cause accumulation of silver deposits in various tissues. This condition is referred to as argyrosis or argyria, whereas changes related to eye tissues are defined as ocular argyrosis.
METHODS: A complete eye examination, corneal confocal microscopy, kinetic and static visual field test, posterior segment optical coherent tomography, pattern visual evoked potentials (PVEP), flash visual evoked potentials, multifocal electroretinogram, pattern electroretinogram (PERG), full-field electroretinography (FERG) and electrooculogram were all performed.
RESULTS: Eye examination revealed decreased visual acuity, corneal deposits and drusenoid changes within the macula. Although electrophysiology tests did not show changes in the function of retinal pigment epithelium, they revealed abnormal function of photoreceptors in the central and peripheral retina. PERG abnormalities and delayed latency of P100 wave in PVEP confirmed impaired function of the inner layers of the retina in the macular region.
CONCLUSIONS: Corneal confocal microscopy and electrophysiological tests may help confirm the diagnosis of ocular argyrosis.