颅面重复畸形是儿科实践中的罕见现象。本报告涉及德国荷斯坦公牛，可归类为双头畸形。胎儿切开术后分娩了表现出双重面孔的胎儿。据我们所知,这是对具有两个颅腔和两个独立的小牛脑的双骨的首次描述，显示了潜在的重复程度。在整个工作中，还回答了一个问题，即牛物种的这种畸形是否来自一个胚胎，或者更确切地说，通过对来自diprosopus两个部分的组织样本进行基因分型，有一个合子背景。关于病因学，不仅遗传倾向，包括信号分子Sonichedgehog介导颅面形态发生调节的功能失败，但也讨论了不完全分离的单卵双胞胎。
Craniofacial duplication abnormity is a rare phenomenon in buiatric practice. This report attends to a male German Holstein calf which could be classified as a diprosopic iniodymus. A fetus exhibiting a doubled face was delivered after fetotomy. To our knowledge, this is the first description of diprosopiasis with two cranial cavities as well as two separate encephala in a calf showing the potential extent of duplication. Throughout this work also the question is answered of whether this malformation in a bovine species arose from one embryo or rather, there is a dizygotic background by genotyping of tissue samples from both parts of the diprosopus. Regarding etiology, not only hereditary dispositions including among others a failed function of the signaling molecule Sonic hedgehog mediating regulation of craniofacial morphogenesis, but also incompletely separated monozygotic twins are discussed.
