骨关节炎（OA）是一种常见的退行性关节疾病，在全球范围内对老年人群有不成比例的影响。由于衰老是OA的重要危险因素，越来越迫切需要开发针对与这种疾病相关的潜在衰老机制的特定疗法。本摘要旨在全面介绍正在进行的研究工作，旨在开发在OA背景下对抗衰老的疗法。细胞衰老在软骨完整性的恶化以及慢性炎症和组织重塑的延续中起着关键作用。因此,靶向SnCs已成为缓解症状和阻碍OA进展的有希望的治疗方法.这篇综述研究了一系列方法，包括针对SnCs的抗衰老药物，调节衰老相关分泌表型（SASP）的衰老形态学，以及增强免疫系统清除SnCs的干预措施。新颖的方法，例如利用新材料进行外泌体递送和精确施用抗衰老药物，为OA的精确治疗提供了有希望的途径。越来越多的证据强调了在OA管理中靶向衰老的潜力，可能有助于开发更有效和个性化的治疗干预措施。
Osteoarthritis (OA) is a common degenerative joint disease that disproportionately impacts the elderly population on a global scale. As aging is a significant risk factor for OA, there is a growing urgency to develop specific therapies that target the underlying mechanisms of aging associated with this condition. This summary seeks to offer a thorough introduction of ongoing research efforts aimed at developing therapies to combat senescence in the context of OA. Cellular senescence plays a pivotal role in both the deterioration of cartilage integrity and the perpetuation of chronic inflammation and tissue remodeling. Consequently, targeting SnCs has emerged as a promising therapeutic approach to alleviate symptoms and hinder the progression of OA. This
review examines a range of approaches, including senolytic drugs targeting SnCs,
senomorphics that modulate the senescence-associated secretory phenotype (SASP), and interventions that enhance immune system clearance of SnCs. Novel methodologies, such as utilizing novel materials for exosome delivery and administering anti-aging medications with precision, offer promising avenues for the precise treatment of OA. Accumulating evidence underscores the potential of targeting senescence in OA management, potentially facilitating the development of more effective and personalized therapeutic interventions.
