耗竭和衰老T细胞的效应子功能受损与癌症进展和疫苗应答不足有关。运动已被证明可以改善癌症治疗和疫苗功效,最有可能通过改善免疫功能。然而,鉴于术语和定义不一致,运动与疲惫和衰老T细胞之间的相互作用尚不清楚。因此,我们进行了系统评价,以研究运动对衰老和耗尽的CD8+T细胞群体的影响,这些细胞群体由蛋白质表面标记物明确定义。包括30篇文章,大多数(n=24)报告根据各种表面标记定义的衰老T细胞群。通过限制衰老和耗尽的CD8+T细胞的积累,重复运动被证明是有益的。该结果可能与运动诱导的促进外周血区室凋亡的衰老T细胞的优先动员有关。未来的研究需要确定这种效应在癌症预防和疫苗功效中的临床相关性。由于缺乏可用的高质量研究,有关运动和耗尽T细胞的数据有限。未来的研究需要控制混杂变量,如性别和巨细胞病毒(CMV)状态,和疲惫和衰老T细胞群体的一致定义,以改善研究和干预措施之间的比较。
The impaired effector function of exhausted and
senescent T cells is implicated in cancer progression and inadequate vaccine responses. Exercise has been shown to improve cancer therapy and vaccine efficacy, most likely by improving immune function. However, given inconsistent terminology and definitions, the interactions between exercise and exhausted and
senescent T cells remain unclear. We therefore performed a systematic
review to investigate the effect of exercise on
senescent and exhausted CD8+ T cell populations clearly defined by protein surface markers. Thirty articles were included, with the majority (n = 24) reporting
senescent T cell populations defined according to a variety of surface markers. Repeated exercise was shown to be beneficial through limiting the accumulation of
senescent and exhausted CD8+ T cells. This outcome is likely related to exercise-induced preferential mobilization of senescent T cells promoting apoptosis in the peripheral blood compartment. Future studies need to determine the clinical relevance of this effect in cancer prevention and vaccine efficacy. Data regarding exercise and exhausted T cells are limited due to a lack of available high-quality studies. Future studies require the control of confounding variables such as sex and cytomegalovirus (CMV) status, and consistent definitions of exhausted and senescent T cell populations to improve comparisons between studies and interventions.