从1986年开始,只有一份关于碘缺乏导致犬类甲状腺功能减退的报告。本病例报告描述了被诊断为碘缺乏引起的甲状腺肿性甲状腺功能减退症的狗的新诊断方法和长期结果。一个4岁的孩子绝育,雌性波美拉尼亚犬出现宫颈肿块,嗜睡,和不活动。这只狗有吃私人卖家出售的家常菜1年的历史。体格检查和超声检查显示宫颈中部有两个双侧对称肿块(左,1.8×1.4厘米;右,2.3×1.8厘米),他们被怀疑是甲状腺。为了识别甲状腺的功能,测量甲状腺激素的基础浓度[总T4(tT4)和促甲状腺激素(TSH)]并进行TSH刺激测试:基线tT4,0.5μg/dL(参考间隔,1-4μg/dL),基线TSH,0.81μg/dL(参考间隔,0.05-0.42μg/dL),和tT4后,1μg/dL(注射TSH后6小时)。数值提示原发性甲状腺功能减退症。尿碘浓度为302μg/L,显著低于正常犬(1,289μg/L)。还进行了99m高tech酸盐的甲状腺闪烁显像,以量化甲状腺的活性,甲状腺与唾液的比值为3.35.根据这些检查和病史的结果,这只狗被诊断为饮食诱导(碘缺乏)甲状腺功能减退。用碘(62.5μg/天)处理狗。治疗后31天,临床体征和甲状腺激素恢复正常(tT4,1.3μg/dL;TSH,0.24μg/dL)。治疗一年后,狗的甲状腺激素浓度正常(tT4,1.8μg/dL;TSH,0.27μg/dL)和部分减少的甲状腺肿(左,1.6×1.1厘米;右侧,1.2×0.9厘米)。这是第一个描述新的诊断方法和诊断为碘缺乏引起的甲状腺肿性甲状腺功能减退症的狗的长期结果的案例。
There is only one previous report of canine goitrous hypothyroidism caused by iodine deficiency from 1986. The present
case report describes the novel diagnostic methods and long-term outcomes of a dog diagnosed with goitrous hypothyroidism caused by iodine deficiency. A 4-year-old neutered, female Pomeranian dog presented with a cervical mass, lethargy, and inactivity. The dog had a history of eating home-cooked diets sold by a private seller for 1 year. The physical examination and ultrasonography showed two bilaterally symmetric masses in the mid-cervical area (left, 1.8 × 1.4 cm; right, 2.3 × 1.8 cm), and they were suspected to be the thyroid glands. To identify the function of the thyroid gland, the basal concentrations of thyroid hormones [total T4 (tT4) and thyroid-stimulating hormone (TSH)] were measured and a TSH stimulation test was performed: baseline tT4, 0.5 μg/dL (reference interval, 1-4 μg/dL), baseline TSH, 0.81 μg/dL (reference interval, 0.05-0.42 μg/dL), and post-tT4, 1 μg/dL (6 h after the injection of TSH). The values indicated primary hypothyroidism. The urinary iodine concentration was 302 μg/L, which was markedly lower than that of normal dogs (1,289 μg/L). Thyroid
scintigraphy with technetium-99m pertechnetate was also performed to quantify the activity of the thyroid gland, and the thyroid-to-salivary ratio was 3.35. Based on the results of these examinations and patient history, the dog was diagnosed with diet-induced (iodine deficiency) goitrous hypothyroidism. The dog was treated with iodine (62.5 μg/day). At 31 days after treatment, clinical signs and thyroid hormones were normalized (tT4, 1.3 μg/dL; TSH, 0.24 μg/dL). One year after treatment, the dog was well with normal concentrations of thyroid hormones (tT4, 1.8 μg/dL; TSH, 0.27 μg/dL) and a partially reduced goiter (left, 1.6 × 1.1 cm; right, 1.2 × 0.9 cm). This is the first
case to describe novel diagnostic methods and long-term outcomes of a dog diagnosed with goitrous hypothyroidism caused by iodine deficiency.