Scientific Misconduct

科学不端行为
  • 文章类型: Journal Article
    目的:本调查的主要目的是探讨医学文献中的作者身份归属与对科学不当行为的责任之间的联系,同时评估作者多重性对所施加制裁的严重程度的影响。
    方法:使用Probit回归模型来审查作者身份对承担科学不端行为责任的影响,并使用无序的多项逻辑回归模型来检验作者身份和副词数量对惩罚措施严重程度的影响。
    结果:第一作者和通讯作者比其他作者更有可能对科学不端行为负责,并且更有可能受到特别严厉的处罚。此外,作者\'从属关系的数量与惩罚性措施的严重程度呈负相关.
    结论:作者身份对科研不端行为中的责任归属有显著影响,特别明显的是,由于第一作者和通讯作者的主要角色,他们面临的严厉处罚风险增加。因此,科研机构和期刊必须精心划定作者规范,明智地确定作者的贡献,支持旨在促进科学研究诚信的举措,并维护有利于强有力的科学调查的环境。
    OBJECTIVE: The primary objective of this inquiry was to explore the nexus between authorship attribution in medical literature and accountability for scientific impropriety while assessing the influence of authorial multiplicity on the severity of sanctions imposed.
    METHODS: Probit regression models were employed to scrutinize the impact of authorship on assuming accountability for scientific misconduct, and unordered multinomial logistic regression models were used to examine the influence of authorship and the number of bylines on the severity of punitive measures.
    RESULTS: First authors and corresponding authors were significantly more likely to be liable for scientific misconduct than other authors and were more likely to be penalized particularly severely. Furthermore, a negative correlation was observed between the number of authors\' affiliations and the severity of punitive measures.
    CONCLUSIONS: Authorship exerts a pronounced influence on the attribution of accountability in scientific research misconduct, particularly evident in the heightened risk of severe penalties confronting first and corresponding authors owing to their principal roles. Hence, scientific research institutions and journals must delineate authorship specifications meticulously, ascertain authors\' contributions judiciously, bolster initiatives aimed at fostering scientific research integrity, and uphold an environment conducive for robust scientific inquiry.
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  • 文章类型: Journal Article
    背景:国际医学杂志编辑委员会(ICMJE)发表了《行为建议》,报告,编辑,医学期刊学术工作的出版。这些为撰写和编辑医学文章提供了全球标准,包括研究完整性。然而,没有一项研究检查了日本医学期刊“作者指南”的研究完整性相关内容。因此,我们将ICMJE会员期刊中的研究完整性内容与日本医学科学协会(JAMS)的英语和日语期刊中的研究完整性内容进行了比较。
    方法:这是一项描述性文献研究。截至2021年9月1日,我们从JAMS网站上列出的英语和日语期刊以及ICMJE网站上列出的ICMJE成员期刊获得了作者说明。我们比较了作者说明中20个主题(ICMJE建议中的19个主题加上ICMJE的合规性)的存在,并分析了利益冲突披露的内容。
    结果:我们评估了12种ICMJE会员期刊,以及82种英语和99种日语小组委员会期刊。ICMJE成员期刊涵盖的主题中位数为10.5,英语期刊为10,三个是日语期刊。10家(83%)ICMJE成员期刊提到了ICMJE的合规性,75(91%)英语期刊,和29种(29%)日语期刊。七份(64%)ICMJE成员期刊要求使用ICMJE利益冲突披露表格,15种(18%)英语期刊,和一本(1%)日语杂志。
    结论:尽管JAMS英语期刊中的主题与ICMJE成员期刊中的主题相似,在JAMS日语期刊中,ICMJE相关主题纳入的中位数比ICMJE会员期刊低约1/3.希望利益冲突披露政策与ICMJE标准不同的日语期刊采用国际标准,以遏制不当行为并确保出版物质量。
    BACKGROUND: The International Committee of Medical Journal Editors (ICMJE) has published Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals. These provide a global standard for writing and editing medical articles, including research integrity. However, no study has examined the research integrity-related content of Japanese medical journals\' Instructions for Authors. We therefore compared research integrity content in ICMJE member journals with those in the English- and Japanese-language journals of the Japanese Association of Medical Sciences (JAMS).
    METHODS: This was a descriptive literature study. We obtained Instructions for Authors from English- and Japanese-language journals listed on the JAMS website and the ICMJE member journals listed on the ICMJE website as of September 1, 2021. We compared the presence of 20 topics (19 in the ICMJE Recommendations plus compliance with ICMJE) in the Instructions for Authors, and analyzed the content of the conflict of interest disclosure.
    RESULTS: We evaluated 12 ICMJE member journals, and 82 English-language and 99 Japanese-language subcommittee journals. The median number of topics covered was 10.5 for ICMJE member journals, 10 for English-language journals, and three for Japanese-language journals. Compliance with ICMJE was mentioned by 10 (83%) ICMJE member journals, 75 (91%) English-language journals, and 29 (29%) Japanese-language journals. The ICMJE Conflicts of Interest Disclosure Form was requested by seven (64%) ICMJE member journals, 15 (18%) English-language journals, and one (1%) Japanese-language journal.
    CONCLUSIONS: Although the topics in the JAMS English-language journals resembled those in the ICMJE member journals, the median value of ICMJE-related topic inclusion was approximately one-third lower in JAMS Japanese-language journals than in ICMJE member journals. It is hoped that Japanese-language journals whose conflict of interest disclosure policies differ from ICMJE standards will adopt international standards to deter misconduct and ensure publication quality.
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  • 文章类型: Journal Article
    本观点讨论了二级医疗保健数据收集与初级数据收集所涉及的挑战,并在使用二级数据注册研究方案之前提供了建议的数据检查列表。
    This Viewpoint discusses the challenges involved with secondary health care data collection vs primary data collection and provides a list of suggested data checks before registration of a study protocol using secondary data.
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  • 文章类型: Journal Article
    1931年,赫尔曼·J·穆勒的博士后,乔治·D·斯内尔(诺贝尔奖获得者-1980年)发起了一项研究,用小鼠复制穆勒的X射线诱导的果蝇突变发现。Snell未能诱导两种感兴趣的突变,基于苍蝇数据(性别相关致死性/隐性可见突变),即使研究设计良好,使用大剂量的X射线,并发表在《遗传学》杂志上。这些发现从未被穆勒引用过,和斯内尔纸(斯内尔,遗传学20:545-567,1935年)没有引用1927年的穆勒论文(穆勒,科学66:84,1927)。这种情况引发了有关Snell如何撰写论文的问题(例如,忽略了不为穆勒在哺乳动物中的发现提供支持的重要性)。可能会提出一个问题,即是否对Snell施加了专业压力,以淡化他的发现的重要性,这可能会对穆勒的职业生涯和LNT理论产生负面影响。虽然穆勒会受到全世界的关注,并在1946年获得诺贝尔奖,“因为发现X射线可以诱导突变,Snell的阴性突变数据几乎完全被他的当代和随后的辐射遗传学/突变研究人员所忽视。这引发了关于Snell的负面发现的明显缺乏兴趣如何帮助穆勒专业的问题,包括他成功利用果蝇数据影响遗传和癌症风险评估并获得诺贝尔奖。
    In 1931, Hermann J. Muller\'s postdoctoral student, George D. Snell (Nobel Prize recipient--1980) initiated research to replicate with mice Muller\'s X-ray-induced mutational findings with fruit flies. Snell failed to induce the two types of mutations of interest, based on fly data (sex-linked lethals/recessive visible mutations) even though the study was well designed, used large doses of X-rays, and was published in Genetics. These findings were never cited by Muller, and the Snell paper (Snell, Genetics 20:545-567, 1935) did not cite the 1927 Muller paper (Muller, Science 66:84, 1927). This situation raises questions concerning how Snell wrote the paper (e.g., ignoring the significance of not providing support for Muller\'s findings in a mammal). The question may be raised whether professional pressures were placed upon Snell to downplay the significance of his findings, which could have negatively impacted the career of Muller and the LNT theory. While Muller would receive worldwide attention, and receive the Nobel Prize in 1946 \"for the discovery that mutations can be induced by X-rays,\" Snell\'s negative mutation data were almost entirely ignored by his contemporary and subsequent radiation genetics/mutation researchers. This raises questions concerning how the apparent lack of interest in Snell\'s negative findings helped Muller professionally, including his success in using his fruit fly data to influence hereditary and cancer risk assessment and to obtain the Nobel Prize.
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  • 文章类型: Journal Article
    背景:随着众多科学产出的出现,研究不端行为日益受到重视。本研究旨在调查知识,中国西南地区医学居民对研究不端行为的态度和实践。
    方法:从2022年11月至2023年3月在中国西南地区进行了横断面研究。将问卷的链接发送给17家三级医院的教学管理科主任。收集并分析了答案。采用Logistic回归分析探讨居民科研不端行为的相关因素。
    结果:6200名居民被纳入研究,88.5%的参与者参加了研究诚信课程,但53.7%的参与者承认有至少一种形式的研究不端行为.有研究生或以上学历,以第一作者或通讯作者的身份发表论文,参加研究诚信课程,对研究完整性的自我报告知识较低,对研究不当行为的感知后果较低,与研究不当行为呈正相关。担任研究项目的主要研究员与研究不当行为呈负相关。大多数居民(66.3%)认为研究不端行为的原因是研究人员缺乏研究能力。
    结论:中国西南地区居民自我报告的研究不端行为率很高,这凸显了在住院医师项目中加强研究诚信课程的普遍必要性。中国当前培训的无效性表明,全球可能需要重新评估和改进教育方法以促进研究诚信。应对这些挑战不仅对于中国医学研究和患者护理的信誉至关重要,而且对于保持全球医学教育的最高道德标准也至关重要。政策制定者,教育工作者,和全球范围内的医疗保健领导者应合作建立全面的战略,以确保负责任的研究进行,最终维护医学进步的完整性,并促进对跨境科学努力的信任。
    BACKGROUND: With the emergence of numerous scientific outputs, growing attention is paid to research misconduct. This study aimed to investigate knowledge, attitudes and practices about research misconduct among medical residents in southwest China.
    METHODS: A cross-sectional study was conducted in southwest China from November 2022 through March 2023. The links to the questionnaire were sent to the directors of the teaching management department in 17 tertiary hospitals. Answers were collected and analyzed. Logistic regression analysis was performed to explore the factors associated with research misconduct among residents.
    RESULTS: 6200 residents were enrolled in the study, and 88.5% of participants attended a course on research integrity, but 53.7% of participants admitted to having committed at least one form of research misconduct. Having a postgraduate or above, publishing papers as the first author or corresponding author, attending a course on research integrity, lower self-reported knowledge on research integrity and lower perceived consequences for research misconduct were positively correlated to research misconduct. Serving as a primary investigator for a research project was negatively associated with research misconduct. Most residents (66.3%) agreed that the reason for research misconduct is that researchers lack research ability.
    CONCLUSIONS: The high self-reported rate of research misconduct among residents in southwest China underscores a universal necessity for enhancing research integrity courses in residency programs. The ineffectiveness of current training in China suggests a possible global need for reevaluating and improving educational approaches to foster research integrity. Addressing these challenges is imperative not only for the credibility of medical research and patient care in China but also for maintaining the highest ethical standards in medical education worldwide. Policymakers, educators, and healthcare leaders on a global scale should collaborate to establish comprehensive strategies that ensure the responsible conduct of research, ultimately safeguarding the integrity of medical advancements and promoting trust in scientific endeavors across borders.
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  • 文章类型: Journal Article
    这项研究试图确定这些看法,西班牙研究人员对科学不端行为的不同方面的态度和经验,总体和性别,多年的研究经验,和研究机构的类型。这是一项基于匿名在线调查的横断面研究,针对生物医学领域的研究人员。该调查包括涵盖社会人口统计数据的第一块(13个问题),第二个街区(14个问题)涵盖了研究人员的看法,态度和经验。进行了描述性分析。403名研究人员回答了调查:51.1%(n=205)的女性,中位年龄45岁。科学不端行为的观察频率为78.8%,43.3%的研究人员承认故意从事某种类型的科学不端行为(自我报告的频率)。最常见的科学不端行为是虚假作者身份。最常见的观察和自我报告的科学不端行为类型似乎没有多年的经验不同,但确实因性别和研究机构类型而异。总之,西班牙生物医学科学研究人员中科学不端行为的频率很高。10名研究人员中有4人认识到参与了任何类型的科学不端行为。根据不同的特点,最常见的不当行为类型之间存在差异,主要是机构类型。
    This study sought to identify the perceptions, attitudes and experiences of Spanish researchers regarding different aspects relating to scientific misconduct, both overall and by gender, years of research experience, and type of research institution. This is a cross-sectional study based on an anonymous online survey, targeting researchers in the field of biomedicine. The survey comprised a first block (13 questions) covering sociodemographic data, and a second block (14 questions) covering researchers\' perceptions, attitudes and experiences. A descriptive analysis was performed. 403 researchers answered the survey: 51.1% (n = 205) women, median age 45 years. The observed frequency of scientific misconduct was 78.8%. Additionally, 43.3% of researchers acknowledged having intentionally engaged in some type of scientific misconduct (self-reported frequency). The most frequent type of scientific misconduct was false authorship. The most frequent types of both observed and self-reported scientific misconduct did not appear to differ by years of experience but did differ by gender and type of research institution. In conclusion, there is a high frequency of scientific misconduct among Spanish biomedical science researchers as 4 of 10 researchers recognized that took part in any type of scientific misconduct. There are differences between the most frequent types of misconduct according to different characteristics, mainly type of institution.
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  • 文章类型: Journal Article
    我们检查了10个学科的134个医学期刊上撤回文章的作者的性别分布,将其与所有已发表文章的作者的性别分布进行比较,发现女性在撤回文章的作者中代表性不足,and,特别是,因不当行为而撤回的文章。
    We examined the gender distribution of authors of retracted articles in 134 medical journals across 10 disciplines, compared it with the gender distribution of authors of all published articles, and found that women were underrepresented among authors of retracted articles, and, in particular, of articles retracted for misconduct.
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  • 文章类型: Journal Article
    该研究旨在检查与不同道德基础相关的单词的使用是否可以预测研究不端行为的严重程度。我们给了两组参与者,本科医学生,研究不端行为案例的假设情景相同,其中包含与道德不同方面相关的词语,并要求他们评估所描述的行为有多不恰当。学生根据行为的不当性对所描述的行为进行不同的排名,但小组措辞并不是恰当性的显著预测指标.排名的原因与研究诚信的任何标准化程序无关,但与学生的道德评估有关,这是使用定性方法进行评估的。这项研究的结果表明,个人道德观是研究诚信培训的重要组成部分。
    The study aimed to examine whether the use of words related to different moral foundations can predict the perceived severity of research misconduct. We gave two groups of participants, undergraduate medical students, the same hypothetical scenarios of research misconduct cases containing words related to different aspects of morality, and asked them to assess how inappropriate the described behavior was. Students ranked the described behaviors differently by the inappropriateness of the behavior, but the group wording was not a significant predictor of appropriateness. The reasons for the ranking were not related to any standardized procedures for research integrity but were related to the moral assessment of the students, which was assessed using qualitative approach. The results of this study implicate that personal moral views are an important part in research integrity training.
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  • 文章类型: Journal Article
    研究完整性(RI)和研究伦理(RE)的结构和实践在各国之间有所不同。本研究分析了欧洲RI和RE的流程和结构,遵循世界研究诚信大会制定的框架。我们为16个欧洲国家提供RI和RE国家报告卡,其中包括RI和RE结构的信息,过程和结果。虽然一些国家在RI和RE方面是领跑者,有了完善和不断发展的政策和结构,其他人刚刚开始他们在RI和RE的旅程。尽管必须考虑RI和RE上下文差异,各国之间的协调水平是必要的,以便在欧洲地区工作的研究人员可以类似地处理RI和RE问题,并有类似的期望,无论他们在哪个组织工作。RI和RE国家报告卡可以作为监控工具,比较,并通过良好做法和发达系统的实例赋予权力和启发,加强各国的研究道德和诚信。
    Structures for and practices of research integrity (RI) and research ethics (RE) differ among countries. This study analyzed the processes and structures for RI and RE in Europe, following the framework developed at the World Conferences on Research Integrity. We present RI and RE Country Report Cards for 16 European countries, which included the information on RI and RE structures, processes and outcomes. While some of the countries are front-runners when it comes to RI and RE, with well-established and continually developing policies and structures, others are just starting their journey in RI and RE. Although RI and RE contextual divergences must be taken into account, a level of harmonization among the countries is necessary so that researchers working in the European area can similarly handle RI and RE issues and have similar expectations regardless of the organization in which they work. RI and RE Country Report Cards can be a tool to monitor, compare, and strengthen RE and integrity across countries through empowerment and inspiration by examples of good practices and developed systems.
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  • 文章类型: Journal Article
    研究背景:研究完整性在研究界得到了广泛的关注,而且在公众中也是如此。提高研究完整性是困难的,因为它涉及复杂的知识系统,态度,和实践。这项研究的目的是调查知识,态度,以及随着时间的推移,一个学院(医学)的博士候选人队列的实践,并将其与同一队列的完成博士学位进行比较。材料和方法:2019年在奥斯陆大学医学院获得博士学位的研究人员(n=186)被邀请回答有关知识的问卷,与科学不诚实有关的态度和行为。94人回答(50.5%)。将结果与在2010-20年期间回答相同问卷的一年级博士候选人(n=536)和在2016年完成博士学位的人(n=86)的结果进行比较。结果:在2010-2020年期间,1.1%的博士候选人报告从事严重的科学不端行为(FFP),而0.9%的博士候选人报告以误导性的方式呈现结果。2.3%的人报告说,他们知道他们所在部门的人员在过去12个月中从事FFP工作。总计1.5%的人报告经历了从事严重科学不端行为(FFP)的压力,而2.1%的人报告经历了以误导性方式呈现结果的压力。在过去的12个月中,平均有12.8%的报告暴露于有关作者的入选或订购的不道德压力。28.8%的人报告了解他们部门关于研究诚信的书面政策。虽然多年来一些态度有所改善,从2010年到2020年,态度总体上没有太大变化。2019年从奥斯陆大学医学院获得博士学位的博士都没有报告从事FFT或经历过这样做的压力。1.1%的人经历了以其他误导性方式呈现结果的压力,而26.6%的受访者在博士奖学金期间经历过与作者身份有关的不道德压力。4.3%的人知道他们部门的某人以误导的方式提交了结果。一些态度不符合传统的研究完整性概念,但大多数人都同意他们的研究环境显示出研究的完整性。结论:这项长期随访研究表明,很少有博士候选人报告从事严重的科学不端行为,他们这样做的压力很小,除了一些例外,态度符合良好的研究诚信。然而,与作者身份有关的压力相对普遍。从博士候选人到最近完成的博士,研究完整性有了一些改善,但总的来说,随着时间的推移,研究的完整性是稳定的。
    Background: Research integrity has obtained much attention in research communities, but also in the general public. To improve research integrity is difficult as it involves complex systems of knowledge, attitudes, and practices. The objective of this study is to investigate the knowledge, attitudes, and practices of cohorts of PhD candidates at one faculty (of medicine) over time and compare this to finished PhDs of the same cohorts. Material and method: Researchers (n  =  186) awarded the degree PhD at the Faculty of Medicine at the University of Oslo in 2019 were invited to answer a questionnaire about knowledge, attitudes and actions related to scientific dishonesty. 94 responded (50.5%). The results were compared with results among first-year PhD candidates who responded to the same questionnaire during 2010-20 (n  =  536) and to those who finished PhDs in 2016 (n  =  86). Results: For the years 2010-2020 1.1% of the PhD candidates report to have engaged in severe scientific misconduct (FFP) while 0.9% report to have presented results in a misleading way. 2.3% report that they know of persons at their department who have engaged in FFP the last 12 months. In total 1.5% report to have experienced pressure to engage in severe scientific misconduct (FFP) while 2.1% report to have experienced pressure to present results in a misleading way. On average 12.8% report to have been exposed to unethical pressure concerning inclusion or ordering of authors during the last 12 months, and 28.8% report to have knowledge about their department\'s written policies about research integrity. While some attitudes improve over the years, attitudes in general are not much changed from 2010-2020. None of the PhDs that received a PhD from the Faculty of Medicine at the University of Oslo in 2019 reported to have engaged in FFT or having experienced pressure to do so.1.1% experienced pressure to present results in other misleading ways, while 26.6% of respondents had experienced unethical pressure in relation to authorship during the course of the PhD fellowship. 4.3% knew about someone at their department who had presented results in a misleading manner. Some attitudes were not in line with traditional conceptions of research integrity, but most agreed that their research environment displayed research integrity. Conclusion: This long-term follow up study shows that few PhD-candidates report to engage in severe scientific misconduct, that they experience little pressure to do so, and with some exceptions, attitudes in in line with good research integrity. However, pressure in relation to authorship is relatively common. There is some improvement in research integrity from PhD candidates to recently finished PhDs, but in general research integrity is stable over time.
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