干燥综合征(SS)是一种多系统自身免疫性疾病,主要针对唾液腺和泪腺;皮肤,鼻腔和阴道干燥,肌肉骨骼疼痛和疲劳是最常见的症状。据推测,听力损失也很常见。这项系统评价的目的是评估干燥综合征患者听力损失及其不同亚型的患病率。遵循PRISMA指南,以确保我们系统审查的最高质量。使用I2作为异质性指标进行随机效应模型的荟萃分析和荟萃回归。本系统综述包括11项观察性研究。其中十个是横截面的,而一项研究是病例对照。评估研究的偏倚风险:所有研究都被评为中等水平,除了两个等级很低。任何类型的听力损失的合并患病率为52.2%。在排除评级为中等偏倚的研究后,合并的听力损失患病率为36.7%.我们还根据听力损失的类型进行了亚组分析。感觉神经性听力损失的总患病率为42.6%。,而传导性听力损失和混合性听力损失的合并患病率分别为5%和2.3%,分别。进行元回归是为了确定能够解释研究之间高度异质性的可能变量。分别发现样本量和研究年份是感音神经性听力损失研究之间异质性的一部分。还发现研究年份是传导性听力损失研究之间异质性的一部分。总之,感觉神经性听力损失,在干燥综合征患者中非常普遍。在此基础上,通过纯音测听法对干燥综合征患者进行早期筛查和随访很重要.
Sjögren syndrome (
SS) is a multisystem autoimmune disease, primarily targeting salivary and lacrimal glands; skin, nasal and vaginal dryness, along with musculoskeletal pain and fatigue are the most commonly reported symptoms. Hearing loss is hypothesized to be frequent as well. The purpose of this systematic
review was to estimate the prevalence of Hearing loss and its different subtypes in patients with Sjögren syndrome. PRISMA guidelines were followed to ensure highest quality for our systematic
review. A random effects model meta-analysis and meta-regression was conducted using I2 as heterogeneity indicator. Eleven observational studies were included in this systematic
review. Ten of them were cross-sectional, while one study was case-control. Studies were assessed for risk of bias: all were rated to a moderate level, except for two rated to a low level. Pooled prevalence of any type of hearing loss was 52.2%. After excluding studies rated to moderate bias, the pooled prevalence of hearing loss was 36.7%. We also conducted a subgroup analysis depending on type of hearing loss. Pooled prevalence of sensorineural hearing loss was 42.6%., while pooled prevalence of conductive hearing loss and mixed hearing loss were 5% and 2.3%, respectively. Meta-regression was conducted in an effort to identify possible variables capable to explain high heterogeneity between studies. Sample size and year of study were separately found to account for a portion of heterogeneity between studies of sensorineural hearing loss. Year of study was also found to account for a portion of heterogeneity between studies of conductive hearing loss. In conclusion, sensorineural hearing loss, is highly prevalent in patients with Sjögren syndrome. On this basis, early screening and follow-up of patients with Sjögren syndrome by pure tone audiometry is important.