溴化钾是一种常用的抗癫痫药物,半衰期超过25天。口服氯化钠的摄入以及肾功能影响这一半衰期,并可能对获得适当血清水平所需的剂量产生影响。假设是,生活在沿海地区附近的狗比生活在内陆的狗需要更大的溴化钾剂量。主要研究目的是确定溴化物剂量之间的关系,血清溴化物浓度,治疗持续时间,食物的种类,并行治疗和狗的居住地接近沿海地区。进行了回顾性横断面研究。从兽医学院的实验室档案中检索到总共658份溴化物血清测量值,乌得勒支大学,荷兰。关于溴化物剂量的信息,肾功能,治疗期,食物的种类,我们通过一项邮政调查,回顾性地从所有犬只的主人那里获得了同步治疗和居住地.创建了220个独特研究单元的数据集。根据狗的居住地(靠近海岸>或<50km)对狗进行分组。两组狗之间关于溴化物剂量的差异,血清溴化物浓度,治疗持续时间,对食物类型和同步治疗进行分析,以评估滞留对溴化物剂量和血清浓度的影响.
■尽管没有统计学意义,但与生活在内陆的狗相比,生活在靠近大海的狗可能需要更高剂量的溴化钾来维持治疗浓度。需要更多的研究来进一步探索这一观察结果。
Potassium bromide is a frequently used antiseizure medication with a half-life time of over 25 days. Oral intake of sodium chloride as well as renal function influence this half-life time and may have an influence on the needed dose to get proper serum levels. The hypothesis is that dogs living close to coastal areas require a greater potassium bromide dose than dogs living more inland. The main
study objective was to determine the relationship between bromide dose, serum bromide concentration, treatment duration, type of food, concurrent therapies and the proximity of the dog\'s residency to a coastal area. A retrospective cross-sectional
study was performed. A total of 658 bromide serum measurements were retrieved from the veterinary faculty\'s laboratory archive, Utrecht University, The Netherlands. Information on the bromide dose, renal function, treatment period, type of food, concurrent therapies and residence was obtained retrospectively from owners of all dogs using a postal survey. A dataset of 220 unique
study units was created. The dogs were grouped based on their residence (proximity to the coast > or <50 km). Differences between the groups of dogs regarding bromide dose, serum bromide concentration, treatment duration, type of food and concurrent therapies were analyzed to evaluate the effect of residence on bromide dose and serum concentration.
UNASSIGNED: Although not statistically significant there is a trend that dogs living in close proximity to the
sea may require a higher dose of potassium bromide to maintain therapeutic concentrations compared to dogs living more inlands. Additional studies are needed to further explore this observation.