蛋白质S-100B是越来越多地用于神经外科和神经重症监护的生物标志物。作为一个相对敏感的,但不具体,中枢神经系统病理学指标,在解释血清S-100B水平时,必须清楚地了解潜在的错误来源.此病例报告研究了一名46岁的慢性硬膜下出血的绅士的病程,血清S-100B水平为22μg/l,还有恶性黑色素瘤的病史.评估了S-100B的颅内和颅外来源,暗示几种来源对总血清浓度的贡献不清楚。讨论了解释S-100B血清浓度时的潜在误差来源。
The protein S-100B is a biomarker increasingly used within neurosurgery and neurointensive care. As a relatively sensitive, yet unspecific, indicator of CNS pathology, potential sources of error must be clearly understood when interpreting serum S-100B levels. This
case report studied the course of a 46-year-old gentleman with a chronic subdural hemorrhage, serum S-100B levels of 22 μg/l, and a history of malignant melanoma. Both intra- and extra-cranial sources of S-100B are evaluated and imply an unclear contribution of several sources to the total serum concentration. Potential sources of error when interpreting serum concentrations of S-100B are discussed.