胃癌(GC)是世界上第四大最常见的癌症,2015年估计有103.4万新病例,是癌症死亡的第三大原因,2014年估计为785,558。早期诊断和治疗极大地影响了GC患者的生存率:早期GC的5年生存率达到90%-95%,而如果GC发展到晚期,死亡率显着增加。最近,研究RhoA在疾病中的作用已成为一个热门话题,特别是在肿瘤的发展中。一项研究发现,RhoA可以调节肌动蛋白的聚合,细胞粘附,运动肌球蛋白,细胞转化,以及参与细胞运动活动的能力,扩散,迁移,与肿瘤细胞的侵袭和转移密切相关。然而,RhoA在肿瘤细胞中的具体作用还有待研究。因此,我们目前的研究旨在简要回顾RhoA在GC中的作用,特别是与GC进展相关的信号通路。
Gastric cancer (GC) is the fourth-most common cancer in the world, with an estimated 1.034 million new cases in 2015, and the third-highest cause of cancer deaths, estimated at 785,558, in 2014. Early diagnosis and treatment greatly affect the survival rate in patients with GC: the 5-year survival rate of early GC reaches 90%-95%, while the mortality rate significantly increases if GC develops to the late stage. Recently, studies for the role of
RhoA in the diseases have become a hot topic, especially in the development of tumors. A
study found that
RhoA can regulate actin polymerization, cell adhesion, motor-myosin, cell transformation, and the ability to participate in the activities of cell movement, proliferation, migration, which are closely related to the invasion and metastasis of tumor cells. However, the specific role of
RhoA in tumor cells remains to be studied. Therefore, our current
study aimed to briefly review the role of
RhoA in GC, especially for its associated signaling pathways involved in the GC progression.