目的:妊娠期糖尿病(GDM)可能与2型糖尿病和肥胖具有相似的发病机制。在目前的研究中,我们旨在验证中国GDM人群中20个与2型糖尿病和肥胖相关的基因.
方法:招募年龄在20-49岁(24-28孕周)的孕妇,556例和445例对照纳入研究。对外周血样本进行单核苷酸多态性(SNP)的基因分型。
结果:我们发现GDM与rs945508相关(OR=1.368,95%CI=1.080-1.732,p=.009),rs10804591(OR=1.446,95%CI=1.192-1.754,p<.001),rs10245353(OR=1.204,95%CI=1.006-1.441,p=.043)和rs1552224(OR=1.451,95%CI=1.071-1.964,p=.016)。
结论:我们发现与2型糖尿病和肥胖相关的4个SNP也可能增加中国人群发生GDM的风险。在这些SNP中,我们首次报道ARHGEF11中的rs945508,PLXND1中的rs10804591和NFE2L3中的rs10245353与GDM相关。
OBJECTIVE: Gestational diabetes mellitus (GDM) may share similar mechanisms with type 2 diabetes and obesity. In the current study, we aimed to verify twenty genes reported to be associated with type 2 diabetes and obesity in the Chinese GDM population.
METHODS: Pregnant women aged 20-49 years at 24-28 gestational weeks were recruited and 556 cases and 445 controls were enrolled in the study. The genotyping of single nucleotide polymorphisms (SNPs) was performed on peripheral blood samples.
RESULTS: We discovered that GDM was associated with rs945508 (OR = 1.368, 95% CI = 1.080-1.732, p = .009), rs10804591 (OR = 1.446, 95% CI = 1.192-1.754, p < .001), rs10245353 (OR = 1.204, 95% CI = 1.006-1.441, p = .043) and rs1552224 (OR = 1.451, 95% CI = 1.071-1.964, p = .016).
CONCLUSIONS: We found that four SNPs associated with type 2 diabetes and obesity may also increase the risk of developing GDM in the Chinese population. Among these SNPs, we report for the first time that rs945508 in ARHGEF11, rs10804591 in PLXND1 and rs10245353 in NFE2L3 were associated with GDM.