Rhinosporidiosis was the commonest (68%) fungal lesion encountered during the period of 11 1/2 years from January 1987 to July 1998. Men in 2nd, 3rd, 4th decade were commonly affected. Nose and nasopharynx were the commonest (85%) sites involved followed by ocular tissue (9%). One patient had involvement of bone (tibia). Generally a lymphoplasmacytic response was observed in all cases. Polymorphonuclear leukocytic response mostly observed at the site of rupture of sporangia. Epithelioid cell granulomatous and giant cell response observed in 47% of cases. Transepithelial migration of sporangia observed in 76% of cases. Rhinosporidium seeberi could be easily identified in haematoxylin and eosin stained sections. The walls of young trophic forms are delineated well with the PAS stain and verhoeff van Gieson stain.

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Two cases of conjunctival rhinosporidiosis were studied by light and electron microscopy. Two distinct phases of the tissue life cycle were present: trophic and endosporulating. Young trophocytes contained a single nucleus. As the trophocyte matured chromatin was dispersed throughout the cyst. During the next phase of the life cycle, sporangial cyst walls acquired a new inner layer that appeared to give rise to endospores. Histochemical and ultrastructural features of Rhinosporidium seeberi are consistent with it being a fungus. Complete surgical excision of the lesion is the only known method to eradicate the infection.

We have morphologically described and ultrastructurally analyzed Rhinosporidium seeberi, the causative agent of rhinosporidiosis, obtained from a nasal polyp of a man who had never traveled to India or Ceylon. The morphology, endosporulation phases, and cell wall were similar to those in previously described infections. A common etiology is suggested and potential therapy is discussed.

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A statistical review of the archives of the Laboratory of Pathologic Anatomy of Maputo Central Hospital is made with the view to determine the frequency of occurrence of rhinosporidiosis in biopsies in the years 1944-86. Diagnosis was made based on the specific microscopic picture shown by the lesions induced by Rhinosporidium seeberi. Of 91,000 reports only 33 cases of the disease were found, which accounts for 0.036% of the total biopsies made in the department. Tissular examinations showed that lesions always appear as polypoid masses lined with hyperplastic epithelium, with an intense inflammatory reaction involving the sporangia, which in slides appear as double-membrane spheres with the occasional rupture-freed spores. It was found that in the series studied the disease appeared most frequently in the period ranging from 10 to 19 years of age, with no sex prevalence. General statistics indicate that the greatest damage was found in bulbar conjunctiva and that location in nostrils was the most frequently found in the age group with the youngest people.