目的:评估流行病学,1998年至2018年慢性主动脉周围炎患者的报告和结局.
方法:1998年1月1日至2018年12月31日在奥姆斯特德县发生慢性主动脉周围炎的患者的初始队列,根据罗切斯特流行病学项目医疗记录链接系统的全面个人医疗记录审查,确定了明尼苏达州。纳入需要影像学和/或组织学证实至少部分肾下腹主动脉或髂总动脉周围的动脉周围软组织增厚。收集了有关人口统计特征的数据,临床表现,肾脏和影像学结果,和死亡率。发病率是根据2010年美国白人人口调整的年龄和性别。
结果:研究期间发现了11例慢性主动脉炎事件。诊断时的平均年龄为61.8±13.4岁。该队列包括9名男性(82%)和2名女性(18%)。每10万人的年龄和性别调整发病率为女性0.26,男性为1.56,总体为0.87。2015年1月1日的总体患病率为每100,000人口8.98。中位随访时间(IQR)为10.1年(2.5,13.8年)。总死亡率与预期年龄相似,性别,和明尼苏达州人群的日历估计值,整个队列的死亡率为2.07(0.67,4.84).
结论:本研究首次报道了美国慢性主动脉周围炎的流行病学数据。在这个慢性主动脉周围炎患者队列中,男性的发病率是女性的4倍。与普通人群相比,死亡率没有增加。
OBJECTIVE: To evaluate the epidemiology, presentation and outcomes of patients with chronic periaortitis from 1998 through 2018.
METHODS: An inception cohort of patients with incident chronic periaortitis from January 1, 1998 through December 31, 2018, in Olmsted County, Minnesota was identified based on comprehensive individual medical record review utilising the Rochester Epidemiology Project medical record linkage system. Inclusion required radiographic and/or histologic confirmation of periarterial soft tissue thickening around at least part of the infra-renal abdominal aorta or the common iliac arteries. Data were collected on demographic characteristics, clinical presentation, renal and radiographic outcomes, and mortality. Incidence rates were age and sex adjusted to the 2010 United States white population.
RESULTS: Eleven incident cases of chronic periaortitis were identified during the
study period. Average age at diagnosis was 61.8±13.4 years. The cohort included 9 men (82%) and 2 women (18%). Age- and sex-adjusted incidence rates per 100,000 population were 0.26 for females, 1.56 for males and 0.87 overall. Overall prevalence on January 1, 2015 was 8.98 per 100,000 population. Median (IQR) length of follow-up was 10.1 (2.5, 13.8) years. Overall mortality was similar to the expected age, sex, and calendar estimates of the Minnesota population with standardised mortality ratio (95% CI) for the entire cohort 2.07 (0.67, 4.84).
CONCLUSIONS: This
study reports the first epidemiologic data on chronic periaortitis in the United States. In this cohort of patients with chronic periaortitis, men were 4 times more commonly affected than women. Mortality was not increased compared to the general population.