横纹肌肉瘤(RMS)在组织学上类似于发育中的骨骼肌,被认为仅源于肌肉祖细胞的分化阻滞。我们证明RMS可以在重编程和肌源性转分化后由内皮祖细胞产生。这些结果强调了具有相同形态特征的肿瘤如何从不同的细胞类型中产生,并提供了对非肌源性组织中RMS形成的了解。
Rhabdomyosarcoma (RMS) histologically resembles developing skeletal muscle and is thought to solely originate from a differentiation block in muscle progenitors. We demonstrate that RMS can arise from endothelial progenitor cells following
reprogramming and myogenic transdifferentiation. These results highlight how tumors with identical morphological features can arise from different cell types and offer insight into RMS formation in non-myogenic tissue.