UNASSIGNED:肾动脉栓塞(RAE)后栓塞后综合征(PES)可降低患者对手术的耐受性并延长住院时间。我们旨在评估接受RAE治疗的血管平滑肌脂肪瘤(AML)患者中类固醇治疗预防PES的疗效。
UNASSIGNED:在2004年5月至2020年3月期间,对26例AML患者进行了29例RAE手术。患者信息,包括年龄,性别,肿瘤大小,结节性硬化症相关/散发性AML,出血性/非出血性AML,栓塞材料,使用类固醇,药物类型,一些血液实验室参数,住院,和PES的发生是回顾性的。研究中使用的预防性类固醇方案如下:在RAE程序前2小时静脉注射250mg甲基强的松龙(Solu-Medrol),然后静脉注射泼尼松龙2天(Predonine;2mg/kg/天),通过在2周内每2天将剂量减半来逐渐减少。放电后,静脉注射泼尼松龙改为口服泼尼松龙(Predonine).PES被定义为发烧的存在,疼痛,恶心,或呕吐。比较类固醇和非类固醇组之间以及PES和非PES组之间的数据。
未经证实:PES发生率为76%,类固醇和非类固醇组之间的比较显示,类固醇使用显着降低PES的发生率(P<0.001),包括发热(P<0.001),疼痛(P=0.005),恶心(P=0.028)。类固醇组住院期间抗炎药物的使用率明显低于对照组(P=0.019)。此外,在类固醇组中,C反应蛋白水平显著降低(P=0.006),而白细胞计数明显较高(P=0.004)。相反,类固醇组的中位住院时间没有显著缩短(P=0.292).
UNASSIGNED:在这项小型回顾性研究中,在肾AML栓塞之前和之后预防性使用类固醇可能有效预防PES。
UNASSIGNED: Postembolization syndrome (PES) after renal arterial embolization (RAE) can reduce the patient\'s tolerance of the procedure and extend the length of hospital stay. We aimed to assess the efficacy of steroid administration in preventing PES in patients undergoing RAE for angiomyolipoma (AML).
UNASSIGNED: Between May 2004 and March 2020, 29 RAE procedures in 26 patients with AML were performed. Patient information, including age, sex, tumor size, tuberous sclerosis complex-associated/sporadic AML, hemorrhagic/nonhemorrhagic AML, embolic material, steroid use, medication type, some blood laboratory parameters, hospital stay, and PES occurrence were retrospectively obtained. The prophylactic steroid protocol used in the
study was as follows: 250 mg of intravenous methylprednisolone (Solu-Medrol) 2 h before the RAE procedure, followed by 2 days of intravenous prednisolone (Predonine; 2 mg/kg/day), which was tapered by halving the dose every 2 days within the course of 2 weeks. After the discharge, intravenous prednisolone was changed to oral prednisolone (Predonine). PES was defined as the presence of fever, pain, nausea, or vomiting. Data were compared between the steroid and non-steroid groups and between PES and non-PES groups.
UNASSIGNED: The PES incidence rate was 76%, and a comparison between the steroid and non-steroid groups revealed that steroid use significantly decreased the incidence of PES (P < 0.001), including fever (P < 0.001), pain (P = 0.005), and nausea (P = 0.028). The use of anti-inflammatory drugs during the hospital stay was significantly lower in the steroid group (P = 0.019). Moreover, in the steroid group, C-reactive protein level was significantly lower (P = 0.006), whereas white blood cell count was significantly higher (P = 0.004). Conversely, the median length of hospital stay was not significantly shorter in the steroid group (P = 0.292).
UNASSIGNED: The prophylactic use of steroids before and after embolization of renal AML may be effective in preventing PES in this small retrospective
study.