以二氧化硅纳米粒子为载体的氯霉素(2,2-二氯-N-[(1R,2R)-1,3-二羟基-1-(4-硝基苯基)丙-2-基]乙酰胺,并装入1%卡波姆基凝胶(聚(丙烯酸))中,这允许获得升级的药物形式。二氧化硅材料的样品是通过改进的Stöber合成获得的,并利用傅里叶变换红外光谱(FTIR)对其形态特性进行了分析,Brunauer-Emmett-Teller(BET)方法,元素分析(EA),热重分析(TGA),比表面性质的分析,X射线衍射研究(XRD),扫描电子显微镜(SEM),和动态光散射(DLS)方法,这允许选择药物载体。将两种获得的二氧化硅载体用氯霉素涂覆并加载到1%卡波姆凝胶中。然后进行释放研究。使用数学模型以及与模型无关的分析评估释放结果。发现通过溶胶-凝胶法合成二氧化硅以形成用氯霉素包覆的产品并进一步研磨二氧化硅材料会影响活性物质的释放,从而允许修改其药物可用性。二氧化硅合成参数的变化影响了所得二氧化硅载体的结构和形态性质。研磨过程决定了活性物质在其表面上的吸附方式。研究表明,适当选择二氧化硅载体对制备的水凝胶制剂的释放曲线具有相当大的影响。
Silica nanoparticles were applied as the carrier of chloramphenicol (2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide), and were loaded in a 1% carbopol-based gel (poly(acrylic acid)), which allowed obtainment of an upgraded drug form. The samples of silica materials were obtained by means of modified Stöber synthesis, and their morphological properties were analyzed using Fourier transform infrared spectroscopy (FTIR), Brunauer-Emmett-Teller (BET) method, elemental analysis (EA), thermogravimetric analysis (TGA), analysis of the specific surface properties, X-ray diffraction
study (XRD), scanning electron microscope (SEM), and dynamic light scattering (DLS) methods, which permitted the selection of the drug carrier. The two obtained silica carriers were coated with chloramphenicol and loaded into 1% carbopol gel. The release studies were then performed. The release results were evaluated using mathematical models as well as model-independent analysis. It was found that the modification of the synthesis of the silica by the sol-gel method to form a product coated with chloramphenicol and further grinding of the silica material influenced the release of the active substance, thus allowing the modification of its pharmaceutical availability. The change in the parameters of silica synthesis influenced the structure and morphological properties of the obtained silica carrier. The grinding process determined the way of adsorption of the active substance on its surface. The studies showed that the proper choice of silica carrier has a considerable effect on the release profile of the prepared hydrogel formulations.