目的:评估流行病学,临床,和巴西南部样本中牙源性囊肿(OCs)的影像学特征,并将结果与国际文献进行比较。
方法:出于主要研究目的,回顾性分析2006年12月至2018年12月的活检和组织病理学记录,选择OC病例,并评估了有关临床特征的数据。Further,我们对类似研究进行了文献综述.
结果:在主要研究中,OCs的患病率为11.26%(n=406),大多数患者为男性(56.73%),平均年龄39±17.33岁。最常见的OC为根底囊肿(46.06%),其次是牙源性角化囊肿(15.02%),牙质囊肿(14.04%),和牙旁囊肿(13.55%)。炎症性OCs在上颌骨(54.84%)和下颌骨发育囊肿(69.92%)更为普遍(p<0.05)。患有炎症性OC的个体通常比患有发育性OC的个体(28.0±19.68岁)年龄更大(41.0±15.34岁)(p<0.05)。关于文献综述,共22篇文章。汇总数据的分析显示,OCs的全球患病率为11.62%(95CI=9.97-13.37),其中最常见的是根性囊肿(54.26%;95CI=49.30-59.18),其次是牙源性角化囊肿(22.94%;95CI=19.22-26.89)和牙源性角化囊肿(11.99%;95CI=8.88-15.49)。此外,来自亚洲(72.40%;95CI=70.30-74.40)和南美洲(68.48%;95CI=64.07-72.72)的研究显示,炎症性OCs发生频率最高.
结论:主要研究表明OCs的患病率为11.26%,这与国际文献相吻合。考虑到OC分布的地理变异性,公共卫生当局和研究人员可以使用这些数据来制定重点预防干预措施,特别是关于炎症性OCs。
OBJECTIVE: To assess epidemiological, clinical, and radiographic characteristics of odontogenic cysts (OCs) in a South Brazilian sample and to compare the results with international literature.
METHODS: For the main study purposes, biopsy and histopathological records were retrospectively analyzed from December 2006 to December 2018, OC cases were selected, and data about clinical characteristics were evaluated. Further, a literature
review was performed for similar studies.
RESULTS: In the main study, the prevalence of OCs was 11.26% (n = 406), the majority of patients was male (56.73%), and the mean age was 39 ± 17.33 years. Radicular cyst was the most common OC (46.06%), followed by the odontogenic keratocyst (15.02%), dentigerous cyst (14.04%), and paradental cyst (13.55%). Inflammatory OCs were more prevalent in the maxilla (54.84%) and developmental cysts in the mandible (69.92%) (p < 0.05). Individuals with inflammatory OCs were usually older (41.0 ± 15.34 years) than the ones with developmental OC (28.0 ± 19.68 years) (p < 0.05). Regarding the literature
review, 22 articles were included. Analysis of pooled data showed that global prevalence of OCs was 11.62% (95%CI = 9.97-13.37), from which radicular cyst was the most common (54.26%; 95%CI = 49.30-59.18), followed by dentigerous cyst (22.94%; 95%CI = 19.22-26.89) and odontogenic keratocyst (11.99%; 95%CI = 8.88-15.49). Furthermore, studies from Asia (72.40%; 95%CI = 70.30-74.40) and South America (68.48%; 95%CI = 64.07-72.72) presented the highest frequencies of inflammatory OCs.
CONCLUSIONS: The main study showed that the prevalence of OCs was 11.26%, which corroborates with international literature. Considering geographic variability of OC distribution, public health authorities and researchers could use these data for the development of focused prevention interventions, especially with regard to inflammatory OCs.