自闭症的感官特征包括对疼痛的低反应性或高反应性；然而，先前关于自闭症疼痛的研究导致了相互矛盾的结果。这里,我们提出了关于自闭症疼痛感知的最新技术和方法论挑战，专注于使用标准化方案作为定量感觉测试(QST)来测量感知的研究。尽管使用QST的证据仍然很少，他们挑战了自闭症患者对疼痛的潜在敏感性，这是从父母的报告中出现的。两者,外围和中心机制，已被发现涉及自闭症感知的典型特征。尽管如此，受控协议的证据仍然很少，甚至更少的是针对儿童的研究。总的来说,为了收集自闭症儿童的主观和客观措施，必须克服复杂的道德挑战。具有异质性的神经发育特征，或者智力残疾，需要新的或修改的协议。
Sensory features of autism include hypo- or hyper-reactivity to pain; however, previous studies on pain in autism lead to conflicting results. Here, we present the state of the art and the methodological challenges concerning pain perception in autism, focusing on studies that used standardized protocol as Quantitative Sensory Testing (QST) to measure perception. Despite there are still scant evidences found with the use of QST, they have challenged the presumed hyposensitivity to pain in autisms, which emerged from parents\' reports. Both, peripheral and central mechanisms, have been found involved in typical features of perception in autism. Nonetheless, evidences with controlled protocols are still scarce, and even scarcer are studies focused on children. Overall, complex ethical challenges have to be overcome in order to collect subjective and objective measures from autistic children. With heterogeneous neurodevelopmental features, or intellectual disability, novel or modified protocols are needed.
