Psychiatric disorders

精神疾病
  • 文章类型: Journal Article
    为重复经颅磁刺激的最佳给药提供指导,以科学证据为基础,辅以专家临床共识。
    文章和信息来自现有指南和已出版文献。然后,作者将研究结果制定为基于共识的建议和指导。该指南在RANZCP内部进行了严格的连续咨询,涉及ECT和神经刺激(SEN)委员会的部门,更广泛的成员和专家委员会。
    rTMS管理的RANZCP专业实践指南(PPG)提供了有关rTMS在临床实践中使用的最新建议。该指南旨在供从事rTMS管理的精神科医生和非精神科医生使用,以促进最佳实践,以优化患者的预后。该指南力求在促进最佳循证实践与承认rTMS使用证据之间找到适当的平衡。
    该指南为精神科医生和非精神科医生提供了最新的建议,以促进rTMS实践的最佳标准。
    UNASSIGNED: To provide guidance for the optimal administration of repetitive transcranial magnetic stimulation, based on scientific evidence and supplemented by expert clinical consensus.
    UNASSIGNED: Articles and information were sourced from existing guidelines and published literature. The findings were then formulated into consensus-based recommendations and guidance by the authors. The guidelines were subjected to rigorous successive consultation within the RANZCP, involving the Section of ECT and Neurostimulation (SEN) Committee, its broader membership and expert committees.
    UNASSIGNED: The RANZCP professional practice guidelines (PPG) for the administration of rTMS provide up-to-date advice regarding the use of rTMS in clinical practice. The guidelines are intended for use by psychiatrists and non-psychiatrists engaged in the administration of rTMS to facilitate best practice to optimise outcomes for patients. The guidelines strive to find the appropriate balance between promoting best evidence-based practice and acknowledging that evidence for rTMS use is a continually evolving.
    UNASSIGNED: The guidelines provide up-to-date advice for psychiatrists and non-psychiatrists to promote optimal standards of rTMS practice.
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  • 文章类型: Journal Article
    遗传研究已经确定了大量的遗传变异,既罕见又常见,潜在的神经发育障碍(NDD)和主要的精神疾病。目前,这些发现正在转化为临床实践。然而,缺乏精神病学基因检测(PsychicGT)和遗传咨询(PschychicGC)的知识和指南.由欧盟资助的COST行动EnGagE(CA17130)网络开始调查PsychGT和PsychGC在35个参与欧洲国家的当前实施状况。这里,我们提供了泛欧在线调查的结果,我们收集了意见,知识,以及对该领域感兴趣的专业人员的自我选择样本的实践。我们收到了181名受访者的答复。三个主要职业类别是遗传咨询师(21.0%),临床遗传学家(24.9%),和研究员(25.4%)。在所有181名受访者中,106为任何精神疾病或NDD提供GC,相当于整个集团的58.6%,从中东欧的43.2%到西欧的66.1%。总的来说,65.2%的受访者表示,基因检测是为NDD患者提供的,对于患有严重精神疾病的个体,有26.5%表示相同。只有22.1%的受访者表示他们有PsychGT指南。15%的人提供了可用于精神疾病的药物遗传学测试。有趣的是,当国家健康保险完全涵盖基因测试时,为NDD患者提供更多基因检测,但不为患有严重精神疾病的患者提供更多基因检测.我们对答复的定性分析强调,缺乏关于利用和使用基因测试以及教育和培训作为实施的主要障碍的准则和知识。的确,只有11.6%的受访者确认存在精神病学遗传培训课程。关于精神病学遗传学最新教育和培训与日常相关实践的相关性的问题是高度相关的。我们提供的证据表明,PsychGC和PsychGT已经在欧洲国家使用,但是缺乏指导和教育。协调实践和制定遗传咨询指南,测试,和培训专业人员将改善平等和获得优质护理的个人在欧洲患有精神疾病。
    Genetic research has identified a large number of genetic variants, both rare and common, underlying neurodevelopmental disorders (NDD) and major psychiatric disorders. Currently, these findings are being translated into clinical practice. However, there is a lack of knowledge and guidelines for psychiatric genetic testing (PsychGT) and genetic counseling (PsychGC). The European Union-funded COST action EnGagE (CA17130) network was started to investigate the current implementation status of PsychGT and PsychGC across 35 participating European countries. Here, we present the results of a pan-European online survey in which we gathered the opinions, knowledge, and practices of a self-selected sample of professionals involved/interested in the field. We received answers from 181 respondents. The three main occupational categories were genetic counselor (21.0%), clinical geneticist (24.9%), and researcher (25.4%). Of all 181 respondents, 106 provide GC for any psychiatric disorder or NDD, corresponding to 58.6% of the whole group ranging from 43.2% in Central Eastern Europe to 66.1% in Western Europe. Overall, 65.2% of the respondents reported that genetic testing is offered to individuals with NDD, and 26.5% indicated the same for individuals with major psychiatric disorders. Only 22.1% of the respondents indicated that they have guidelines for PsychGT. Pharmacogenetic testing actionable for psychiatric disorders was offered by 15%. Interestingly, when genetic tests are fully covered by national health insurance, more genetic testing is provided for individuals with NDD but not those with major psychiatric disorders. Our qualitative analyses of responses highlight the lack of guidelines and knowledge on utilizing and using genetic tests and education and training as the major obstacles to implementation. Indeed, the existence of psychiatric genetic training courses was confirmed by only 11.6% of respondents. The question on the relevance of up-to-date education and training in psychiatric genetics on everyday related practice was highly relevant. We provide evidence that PsychGC and PsychGT are already in use across European countries, but there is a lack of guidelines and education. Harmonization of practice and development of guidelines for genetic counseling, testing, and training professionals would improve equality and access to quality care for individuals with psychiatric disorders within Europe.
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  • 文章类型: Journal Article
    (1)与人群规范相比,检查患有活动性和非活动性癫痫的年轻人的24小时运动指南依从性。(2)调查这些亚群中24小时运动指南依从性与心理健康障碍之间的关联。
    使用了2016年至2019年全国儿童健康调查周期的横截面数据。父母/照顾者的运动行为报告(身体活动,屏幕时间,睡眠,和运动参与)用于确定对24小时运动指南的依从性以及与患有活动性癫痫(n=663)和非活动性癫痫(n=526)以及人群规范(n=49,067)的年轻人的心理健康障碍的关联在6至17岁之间。进行多因素logistic回归分析。
    患有活动性癫痫的年轻人比人口标准更不可能符合24小时运动指南。很大程度上是由低于平均水平的体力活动指南依从性驱动的。患有活动性和非活动性癫痫的年轻人的运动参与度较低;癫痫发作的严重程度和与健康相关的限制起着重要作用。通常观察到24小时运动指南依从性和心理健康障碍之间的有益关联。尽管对于患有活动性和非活动性癫痫的年轻人来说,这些关系之间存在相当大的差异。
    进一步传播国际抗癫痫联盟运动和癫痫特别工作组的报告可以帮助在患有活动性和非活动性癫痫的年轻人中促进身体活动和运动参与。在患有癫痫的年轻人中,24小时运动指南依从性与心理健康障碍之间的关系很复杂,需要进行纵向研究以确定因果关系。
    (1) Examine 24-hour movement guideline adherence among young people with active and inactive epilepsy compared to population norms. (2) Investigate associations between 24-hour movement guideline adherence and mental health disorders among these subpopulations.
    Cross-sectional data from the 2016 to 2019 cycles of the National Survey of Children\'s Health were used. Parental/caregiver reports of movement behaviors (physical activity, screen time, sleep, and sport participation) were used to determine adherence to the 24-hour movement guidelines and associations with mental health disorders for young people with active (n = 663) and inactive epilepsy (n = 526) as well as population norms (n = 49,067) between 6 and 17 years old. Multivariate logistic regression analyses were conducted.
    Young people with active epilepsy were less likely to meet the 24-hour movement guidelines than population norms, largely driven by below average levels of physical activity guideline adherence. Sport participation was lower among both young people with active and inactive epilepsy; seizure severity and health-related limitations played an influential role. Beneficial associations were generally observed between 24-hour movement guideline adherence and mental health disorders, although for young people with active and inactive epilepsy, there was considerable variability among these relationships.
    Further dissemination of the International League Against Epilepsy\'s Task Force on Sports and Epilepsy report can help improve promotion of physical activity and sport participation among young people with active and inactive epilepsy. The relationship between 24-hour movement guideline adherence and mental health disorders is complex among young people with epilepsy and longitudinal research is needed to determine causal links.
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  • 文章类型: Journal Article
    经颅直流电刺激已显示出有希望的临床结果,导致对其临床效果进行循证审查的需求增加。
    我们召集了一组经颅直流电刺激专家,对超过1次刺激测试的临床试验进行系统回顾:疼痛,帕金森病运动功能与认知,中风运动功能和语言,癫痫,重度抑郁症,强迫症,Tourette综合征,精神分裂症,和毒瘾。
    专家被要求根据PRISMA指南的搜索方法进行系统评价。关于疗效的建议分为A级(绝对有效),B(可能有效),C(可能有效)或者没有推荐。我们评估了所有纳入研究的偏倚风险,以确认结果是否由潜在偏倚研究驱动。
    虽然大多数临床试验被设计为概念验证试验,本综述中分析的一些适应症可以被认为是绝对有效的(A级),比如抑郁症,并且可能有效(B级),比如神经性疼痛,纤维肌痛,偏头痛,术后患者自控镇痛和疼痛,帕金森病(运动和认知),行程(马达),癫痫,精神分裂症,酒精成瘾。偏倚评估表明,大多数研究的偏倚风险较低,偏倚的敏感性分析并未改变这些结果.效应大小从0.01到0.70不等,在大约8个条件下是显著的,效果最大的是术后急性疼痛,而中风运动恢复较小(与机器人疗法联合使用时无意义)。
    此处列出的所有建议均基于当前发布的PubMed索引数据。尽管在某些情况下有大量证据,必须强调的是,效果的大小和持续时间通常是有限的;因此,不同的研究设计需要进一步确定真正的临床影响.
    Transcranial direct current stimulation has shown promising clinical results, leading to increased demand for an evidence-based review on its clinical effects.
    We convened a team of transcranial direct current stimulation experts to conduct a systematic review of clinical trials with more than 1 session of stimulation testing: pain, Parkinson\'s disease motor function and cognition, stroke motor function and language, epilepsy, major depressive disorder, obsessive compulsive disorder, Tourette syndrome, schizophrenia, and drug addiction.
    Experts were asked to conduct this systematic review according to the search methodology from PRISMA guidelines. Recommendations on efficacy were categorized into Levels A (definitely effective), B (probably effective), C (possibly effective), or no recommendation. We assessed risk of bias for all included studies to confirm whether results were driven by potentially biased studies.
    Although most of the clinical trials have been designed as proof-of-concept trials, some of the indications analyzed in this review can be considered as definitely effective (Level A), such as depression, and probably effective (Level B), such as neuropathic pain, fibromyalgia, migraine, post-operative patient-controlled analgesia and pain, Parkinson\'s disease (motor and cognition), stroke (motor), epilepsy, schizophrenia, and alcohol addiction. Assessment of bias showed that most of the studies had low risk of biases, and sensitivity analysis for bias did not change these results. Effect sizes vary from 0.01 to 0.70 and were significant in about 8 conditions, with the largest effect size being in postoperative acute pain and smaller in stroke motor recovery (nonsignificant when combined with robotic therapy).
    All recommendations listed here are based on current published PubMed-indexed data. Despite high levels of evidence in some conditions, it must be underscored that effect sizes and duration of effects are often limited; thus, real clinical impact needs to be further determined with different study designs.
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  • 文章类型: Journal Article
    大多数精神疾病与大脑功能的细微改变有关,并且存在很大的个体差异。通常,这些疾病的诊断需要由具有丰富经验的多学科团队进行耗时的行为评估.虽然将机器学习分类方法(ML分类器)应用于神经影像数据有可能加快和简化精神疾病的诊断,方法,假设,和分析步骤目前是不透明的,领域外的研究人员和临床医生无法使用。在本文中,我们描述了自闭症谱系障碍的潜在分类管道,作为精神疾病的一个例子。分析基于从多站点数据存储库(ABIDE)得出的静息状态fMRI数据。我们比较了几种流行的ML分类器,如支持向量机,神经网络,和回归方法,在其他人中。在教程样式中,被写为研究人员和临床医生同样容易获得,我们解释了每种分类方法的基本原理,澄清基本假设,讨论可能的陷阱和挑战。我们还提供数据以及用于实现结果的MATLAB代码。我们证明开箱即用的ML分类器可以产生约60-70%的分类准确率。最后,我们讨论了如何进一步提高分类精度,我们提到了方法学上的发展,为在临床实践中使用ML分类器铺平道路。
    Most psychiatric disorders are associated with subtle alterations in brain function and are subject to large interindividual differences. Typically, the diagnosis of these disorders requires time-consuming behavioral assessments administered by a multidisciplinary team with extensive experience. While the application of Machine Learning classification methods (ML classifiers) to neuroimaging data has the potential to speed and simplify diagnosis of psychiatric disorders, the methods, assumptions, and analytical steps are currently opaque and not accessible to researchers and clinicians outside the field. In this paper, we describe potential classification pipelines for autism spectrum disorder, as an example of a psychiatric disorder. The analyses are based on resting-state fMRI data derived from a multisite data repository (ABIDE). We compare several popular ML classifiers such as support vector machines, neural networks, and regression approaches, among others. In a tutorial style, written to be equally accessible for researchers and clinicians, we explain the rationale of each classification approach, clarify the underlying assumptions, and discuss possible pitfalls and challenges. We also provide the data as well as the MATLAB code we used to achieve our results. We show that out-of-the-box ML classifiers can yield classification accuracies of about 60-70%. Finally, we discuss how classification accuracy can be further improved, and we mention methodological developments that are needed to pave the way for the use of ML classifiers in clinical practice.
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  • 文章类型: Journal Article
    HIV Patient care should include psychological and psychiatric care, which is necessary for early detection thereof. Should suicidal ideation occur, refer the patient to a psychiatric unit. Pharmacological treatment is recommended when there is comorbidity with moderate or severe depression. You should look for the aetiology of neuropsychiatric disorder before using psychoactive drugs in HIV patients. The overall management of the health of HIV adolescents should include an assessment of mental health, environmental stressors and support systems. Training in the management of the patient both own emotions is critical to getting to provide optimal care. These new guidelines updated previous recommendations regarding psychiatric and psychological disorders, including the most common pathologies in adults and children.
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