描述法国儿童的动态质子泵抑制剂(PPI)处方,其趋势,以及法国(2014)和国际(2018)临床指南的影响。
我们根据法国儿童的国家分配数据描述了PPI处方率(IQVIA的Xponent数据库,2009-2019年)。使用分段线性回归,我们评估了临床指南对PPI处方率的影响.对整个儿科人群和年龄亚组进行了分析(婴儿<2岁,2-11岁儿童,青少年12-17岁)。
在研究期间,填写了8060288张儿科PPI处方,平均PPI处方率为每年每1000名居民52.5。在2009年至2019年之间,整个儿科人群的PPI处方率增加了41%(婴儿为110%)。PPI处方率呈季节性规律,冬季为高峰。法国准则发布后,总体上(趋势变化-0.28,95%CI-0.34;-0.23)和所有年龄组的处方率趋势显著下降.在婴儿中,这种趋势的变化不足以逆转PPI处方率随着时间的推移仍在增加.在儿童中,PPI处方率略有下降,青少年,很稳定.国际准则发布后,趋势显著下降仅发生在青少年(趋势变化-0.26,95%CI-0.47;-0.04).
法国的儿科PPI处方率高,在过去的十年中显示出了巨大的增长,主要是婴儿,并且受到临床指南的适度影响。
To describe the ambulatory proton pump inhibitor (PPI) prescription in French children, its trends, and the impact of French (2014) and international (2018) clinical
guidelines.
We described PPI prescription rates based on national dispensation data in French children (IQVIA\'s Xponent database, 2009-2019). Using a segmented linear regression, we assessed the impact of clinical
guidelines on PPI prescription rates. Analyses were performed for the overall pediatric population and by age subgroups (infants <2 years old, children 2-11 years old, adolescents 12-17 years old).
During the study period, 8 060 288 pediatric PPI prescriptions were filled, with a mean PPI prescription rate of 52.5 per 1000 inhabitants per year. Between 2009 and 2019, the PPI prescription rate increased by 41% in the overall pediatric population (+110% in infants). The PPI prescription rate showed seasonal patterns with peaks in winter. After the release of French
guidelines, significant decreases in trends of prescription rates occurred overall (change in trend -0.28, 95% CI -0.34;-0.23) and across all age groups. In infants, this change in trend was not sufficient to reverse the PPI prescription rate that was still increasing over time. In children, the PPI prescription rate slightly decreased and in adolescents, it was stable. After the release of international
guidelines, a significant decrease in trend occurred in adolescents only (change in trend -0.26, 95% CI -0.47; -0.04).
The pediatric PPI prescription rate in France was high, displayed a major increase over the last decade, mainly among infants, and was modestly affected by clinical
guidelines.