■一氧化碳中毒与各种器官的严重损害有关。在这项研究中,我们的目的是确定以前的一氧化碳中毒是否与肺部疾病的风险增加有关。
■研究人群来自2002年1月1日至2021年12月31日之间的韩国国民健康保险服务数据库。一氧化碳中毒的成年人,包括在2002年至2021年期间至少一次访问医疗机构。为了比较,从数据库中选择具有相同索引日期的相同数量的匹配对照.
■本研究共纳入28,618例一氧化碳中毒患者和28,618例匹配对照。约42.8%的患者组和对照组为女性,平均年龄51.3岁。一氧化碳中毒的病人,肺癌风险显著增加(调整后的风险比,1.84;95%置信区间,1.42-2.39;P<0.001),慢性阻塞性肺疾病(调整后的风险比,1.60;95%置信区间,1.36-1.89;P<0.001),肺结核(调整后的危险比,1.46;95%置信区间,1.13-1.88;P=0.003),和非结核分枝杆菌感染(调整后的危险比,1.54;95%置信区间,1.01-2.36;P=0.047)。
■在这项回顾性队列研究中,以前的一氧化碳中毒与肺癌风险增加有关,慢性阻塞性肺疾病,肺结核,和非结核分枝杆菌感染。需要进一步的研究来证实其他人群中的这种关联以及由于来自不同来源的一氧化碳的毒性作用而导致的肺部疾病的风险。
■以前的一氧化碳中毒与肺部疾病的风险增加有关,但是暴露的原因和来源的相对重要性尚不清楚。急性一氧化碳中毒幸存者的长期管理应包括监测肺癌,慢性阻塞性肺疾病,肺结核,和非结核分枝杆菌感染。
UNASSIGNED: Carbon monoxide poisoning is associated with severe damage to various organs. In this
study, we aimed to determine if previous carbon monoxide poisoning was associated with an increased risk of lung diseases.
UNASSIGNED: The
study population was derived from the National Health Insurance Service database of Korea between 1 January 2002 and 31 December 2021. Adults with carbon monoxide poisoning, with at least one visit to medical facilities between 2002 and 2021, were included. For comparison, an equal number of matched controls with the same index date were selected from the database.
UNASSIGNED: A total of 28,618 patients with carbon monoxide poisoning and 28,618 matched controls were included in this
study. Approximately 42.8 per cent of the patient and control groups were female, with a mean age of 51.3 years. In patients with carbon monoxide poisoning, there was a significant increase in the risk of lung cancer (adjusted hazard ratio, 1.84; 95 per cent confidence interval, 1.42-2.39; P < 0.001), chronic obstructive pulmonary disease (adjusted hazard ratio, 1.60; 95 per cent confidence interval, 1.36-1.89; P < 0.001), pulmonary tuberculosis (adjusted hazard ratio, 1.46; 95 per cent confidence interval, 1.13-1.88; P = 0.003), and non-tuberculous mycobacterial infection (adjusted hazard ratio, 1.54; 95 per cent confidence interval, 1.01-2.36; P = 0.047).
UNASSIGNED: In this retrospective cohort
study, previous carbon monoxide poisoning was associated with an increased risk of lung cancer, chronic obstructive pulmonary disease, pulmonary tuberculosis, and non-tuberculous mycobacterial infection. Further studies are needed to confirm such an association in other populations and the risk of lung diseases due to the toxic effect of carbon monoxide from different sources.
UNASSIGNED: Previous carbon monoxide poisoning was associated with an increased risk of lung diseases, but the relative importance of the causes and sources of exposure was not known. The long-term management of survivors of acute carbon monoxide poisoning should include monitoring for lung cancer, chronic obstructive pulmonary disease, pulmonary tuberculosis, and non-tuberculous mycobacterial infection.