李斯特菌病是一种全球罕见的食源性疾病,可导致胎儿胎盘感染,导致不良妊娠结局,虽然在中国,孕妇的研究有限。因此,这项研究旨在分析发病率,临床表现,孕妇李斯特菌病的临床结局及其相关饮食行为危险因素的预防。2017年1月至2021年12月进行了基于医院的病例对照研究。临床数据,实验室信息,并在病例诊断后2天内收集包括饮食行为和个人卫生在内的问卷。有48名孕妇,包括12个病例和36个对照,平均年龄31.19±3.75岁。孕妇中基于入院的李斯特菌病的发生率为1.6058/10,000。12株分为3种血清型:1/2a(83.33%),1/2b(8.33%),和4b(8.33%)。在案件中,5例(41.67%)导致流产,3例(25%)引产早产,治疗后足月分娩4例(33.33%)。病例组中有7例活产,其中6人入住新生儿重症监护病房(NICU),1例胎儿结局健康。对照组所有患者均产下活胎。流行病学调查显示,孕妇每周在餐厅用餐三次或更多次可能会增加感染李斯特菌的风险。饮食消费行为没有显著差异,手部卫生,以及病例组和对照组之间的冰箱使用行为。研究表明,在餐厅用餐可能与孕妇中的李斯特菌感染有关。因此,必须加强对李斯特菌病严重后果的教育,并促进孕妇的健康饮食和卫生习惯。
Listeriosis is a globally rare foodborne disease that causes fetal-placental infection, leading to adverse pregnancy outcome, while limited research among pregnant women is available in China. This study was therefore aimed at analyzing the incidence, clinical manifestations, and clinical outcome of listeriosis among pregnant women and its associated dietary behavior risk factors in prevention. A hospital-based
case-control study had been conducted from January 2017 to December 2021. Clinical data, laboratory information, and questionnaires including dietary behaviors and personal hygiene were collected within 2 days after
case diagnosis. There were 48 pregnant women, including 12 cases and 36 controls, with an average age of 31.19 ± 3.75 years. The incidence of admission-based listeriosis among pregnant women was 1.6058 per 10,000. The 12 strains were divided into 3 serotypes: 1/2a(83.33%), 1/2b(8.33%), and 4b(8.33%). Among the cases, 5 cases (41.67%) resulted in abortion, 3 cases (25%) induced preterm labor, and 4 cases (33.33%) had full-term deliveries after treatment. There were 7 live births in the
case group, among which 6 were admitted to the neonatal intensive care unit (NICU), while 1
case had a healthy fetal outcome. All patients in the control group gave birth to live fetuses. Epidemiological investigation revealed that pregnant women dining at restaurants three or more times per week might increase the risk of having Listeria infection. There were no significant differences in dietary consumed behaviors, hand hygiene, and refrigerator usage behaviors between
case and control groups. The study suggested that dining at restaurants might be associated with Listeria infection among pregnant women. Therefore, it is essential to enhance education on listeriosis serious consequences and promote healthy dietary and hygiene habits among pregnant women.