目的:比较术后5年单片疏水丙烯酸人工晶状体(IOL)植入术后有无后囊斑块的后囊混浊(PCO)的发生情况。
方法:前瞻性观察性病例对照研究。
方法:将100只连续有后囊斑块的眼(病例)与相同数量的无后囊斑块的白内障眼(对照组)进行比较。进行详细的术前评估以检测后囊斑块的存在。评估后囊斑块的组织形态学。术后,在1个月和1年,2年,3年和5年进行数字逆行摄影记录,并使用后囊混浊评估(EPCO)软件进行PCO分析;计算EPCO评分和面积.比较了PCO的发展以及前囊盖(全部和部分)对IOL视神经的影响。
结果:后囊斑块在组织形态上显示大量胶原,纤维细胞外基质,免疫荧光染色α平滑肌肌动蛋白阳性。在PCO的发展中,在1个月和1,2,3和5年时,病例和对照组之间无差异.在两组之间,直到5年,在IOL的前囊完全覆盖和部分覆盖内,PCO的发展没有差异。
结论:5年后囊斑块的存在并没有增加PCO的发生率。
OBJECTIVE: To compare the development of posterior capsule opacification (PCO) between eyes with and without posterior capsule plaque after single-piece hydrophobic acrylic intraocular lens (IOL) implantation 5 years postoperatively.
METHODS: A prospective observational
case-control study.
METHODS: One hundred one consecutive eyes with posterior capsule plaque (cases) were compared with the same number of cataractous eyes without posterior capsule plaque (controls). A detailed preoperative evaluation was done to detect the presence of posterior capsule plaque. Histomorphology of posterior capsule plaque was evaluated. Postoperatively, digital retroillumination photographic documentation was performed at 1 month and 1, 2, 3, and 5 years and analyzed for PCO using the Evaluation of Posterior Capsule Opacification (EPCO) software; EPCO scores and areas were calculated. The development of PCO and the influence of the anterior capsule cover (total and partial) on the IOL optic were compared.
RESULTS: Posterior capsule plaque on histomorphology showed a large amount of collagenous, fibrous extracellular matrix, and immunofluorescence staining was positive for alpha smooth muscle actin. In the development of PCO, there was no difference between cases and controls at 1 month and 1, 2, 3, and 5 years. Between the 2 groups, there was no difference in the development of PCO within total cover and within partial cover of the anterior capsule on the IOL up to 5 years.
CONCLUSIONS: The presence of posterior capsule plaque did not increase the incidence of PCO at 5 years.