本研究报告了患有复发性多软骨炎的小细胞肺癌患者的临床资料。我们报道一例57岁女性咳嗽,咳痰,和发烧。在医院进行的计算机断层扫描(CT)扫描显示两肺支气管壁弥漫性增厚。支气管镜检查显示气管粘膜增厚,缩小,崩溃了,支气管镜可以通过.两侧支气管粘膜增厚,水肿,表面粗糙,每个支气管都是狭窄的,椎间脊变宽了。穿刺活检:结合免疫组织化学结果考虑小细胞癌。抗感染治疗后症状无改善。左耳廓红肿,耳廓塌陷了,左眼在住院期间出现结膜下出血,无明显原因。经过多学科协商,考虑cT0N2Mx瘤胃淋巴结转移和RP。治疗:泼尼松,口服RP。小细胞肺癌给予化疗联合放疗。化疗方案为卡铂联合依托泊苷。患者接受放化疗后已随访1年,目前病情稳定。根据我们病人的情况,对于有耳廓软骨炎等症状的RP病例,眼部炎性疾病,和鼻软骨炎,我们应该高度重视该病例是否由肺癌引起的复发性多软骨炎。由于这种疾病的罕见,临床医生应提高对疾病的认识,争取早期诊断和治疗。
The present study
reports the clinical data of a patient with small cell lung cancer who developed relapsing polychondritis. We report a
case of a 57-year-old female presented with cough, expectoration, and fever. A Computed Tomography (CT) scan performed at the hospital revealed diffuse thickening of bronchial walls in both lungs. Bronchoscopy revealed that the tracheal mucosa was thickened, narrowed, and collapsed, and the bronchoscope could pass through. The bronchial mucosa on both sides was thickened and edematous, the surface was rough, each bronchus was narrow, and the intervertebral ridges were widened. Needle biopsy: considering small cell carcinoma in combination with immunohistochemical results. Her symptom was not improved after anti-infective therapy. The left auricle was red and swollen, the auricle collapsed, and the left eye had subconjunctival hemorrhage during her hospitalization without obvious cause. After multidisciplinary consultation, pulmonary small cell lung cancer cT0N2Mx rumen lymph node metastasis and RP were considered. Treatment: Prednisone, orally for RP. Chemotherapy combined with radiotherapy was given for small cell lung cancer. The chemotherapy regimen was carboplatin combined with etoposide. The patient has already been followed for 1 year after receiving chemoradiotherapy; the condition of the patient is stable at present. Based on the
case of our patient, for cases of RP with symptoms such as auricle chondritis, ocular inflammatory disease, and nasal chondritis, we should pay great attention to whether the
case is caused by lung cancer with relapsing polychondritis. Because of the rarity of the disease, the clinician should improve the recognition of the disease in order to strive for early diagnosis and therapy.