口腔念珠菌病是免疫功能正常的患者中的常见问题。念珠菌菌株对流行的抗真菌药的频繁抗性使得有必要寻找替代的治疗方法。作者遵循PRISMA2020指南进行了系统评价。本综述的目的是确定姜黄素介导的蓝光是否可以被视为口腔念珠菌病的替代疗法。PubMed,谷歌学者,和CochraneLibrary数据库使用以下关键词的组合进行搜索:(念珠菌或念珠菌病口腔或义齿口炎)和(姜黄素或光动力疗法或适当或光动力抗菌化疗或PACT或光动力灭活或PDI)。该综述包括念珠菌属的体外实验室研究。,体内动物研究,以及涉及口腔念珠菌病或假体性口腔炎患者的随机对照试验(RCTs),只以英文出版。研究中消除念珠菌属的方法是姜黄素介导的aPDT。共确定了757项研究。在对研究的标题和摘要进行分析之后,只有42项研究被选中进行深入筛查,之后有26人被纳入本研究.所有研究都评估了姜黄素介导的aPDT对白色念珠菌和非白色念珠菌的抗真菌功效。在用浮游细胞溶液进行的研究中,七项研究表明完全消除了念珠菌。细胞。其余的研究表明仅部分消除。在所有情况下,单物种酵母生物膜的实验证明了部分,具有统计学意义的细胞生长抑制和生物膜质量的减少。在体内,姜黄素介导的aPDT在动物模型中也显示出对口腔念珠菌病的良好抗真菌活性。然而,其作为口腔念珠菌病有效治疗策略的临床疗效几乎不需要进一步的随机对照试验.
Oral candidiasis is a common problem among immunocompetent patients. The frequent resistance of Candida strains to popular antimycotics makes it necessary to look for alternative methods of treatment. The authors conducted a systematic
review following the PRISMA 2020 guidelines. The objective of this
review was to determine if curcumin-mediated blue light could be considered as an alternative treatment for oral candidiasis. PubMed, Google Scholar, and Cochrane Library databases were searched using a combination of the following keywords: (Candida OR candidiasis oral OR candidiasis oral OR denture stomatitis) AND (curcumin OR photodynamic therapy OR apt OR photodynamic antimicrobial chemotherapy OR PACT OR photodynamic inactivation OR PDI). The
review included in vitro laboratory studies with Candida spp., in vivo animal studies, and randomized control trials (RCTs) involving patients with oral candidiasis or prosthetic stomatitis, published only in English. The method of elimination of Candida species in the studies was curcumin-mediated aPDT. A total of 757 studies were identified. Following the analysis of the titles and abstracts of the studies, only 42 studies were selected for in-depth screening, after which 26 were included in this study. All studies evaluated the antifungal efficacy of curcumin-mediated aPDT against C. albicans and non-albicans Candida. In studies conducted with planktonic cells solutions, seven studies demonstrated complete elimination of Candida spp. cells. The remaining studies demonstrated only partial elimination. In all cases, experiments on single-species yeast biofilms demonstrated partial, statistically significant inhibition of cell growth and reduction in biofilm mass. In vivo, curcumin-mediated aPDT has shown good antifungal activity against oral candidiasis also in an animal model. However, its clinical efficacy as a potent therapeutic strategy for oral candidiasis requires few further RCTs.