霉菌病或真菌感染是一种常见的健康问题,通常发生在社区中健康和免疫受损的人群中。真菌耐药菌株的发展和亚太地区的唑类抗生素耐药率达到83%成为当今的关键问题。为了控制真菌感染,从自然资源中分离的物质和提取物,尤其是以植物的形式作为当今药物分子的主要来源,是需要的。特别是来自胡椒科,在印度已经使用了很长时间,中国,和韩国用传统医学治疗人类疾病。这篇综述的目的是描述Pipercrocatum的抗真菌活性及其对羊毛甾醇14α脱甲基酶CYP51的植物化学分析。该方法使用GoogleScholar的搜索数据库,使用系统评论和荟萃分析的首选报告项目(PRISMA)流程图作为临床信息检索方法来查找适当的数据库。从按数据库搜索的1,150,000个结果中,有73篇精选文章需要审查。综述显示,红花山含有黄酮类化合物,单宁,萜烯,皂苷,多酚,丁香酚,生物碱,醌,chavibetol乙酸酯,糖苷,三萜类或类固醇,羟基chavikol,酚类物质,葡糖苷,类异戊二烯,和非蛋白质氨基酸。其在真菌细胞中的抗真菌机制是由于5,6去饱和酶(ERG3)下调导致的麦角甾醇尤其是羊毛甾醇14α脱甲基酶CYP51的抑制而发生的。P.crocatum具有抗真菌活性,通过其植物化学分析,通过抑制真菌细胞色素P450途径来对抗真菌,制造损伤细胞膜,真菌生长抑制,形态变化,和真菌细胞裂解。
Mycoses or fungal infections are a general health problem that often occurs in healthy and immunocompromised people in the community. The development of resistant strains in Fungi and the incidence of azole antibiotic resistance in the Asia Pacific which reached 83% become a critical problem nowadays. To control fungal infections, substances and extracts isolated from natural resources, especially in the form of plants as the main sources of drug molecules today, are needed. Especially from Piperaceae, which have long been used in India, China, and Korea to treat human ailments in traditional medicine. The purpose of this
review is to describe the antifungal mechanism action from Piper crocatum and its phytochemical profiling against lanosterol 14a demethylase CYP51. The methods used to search databases from Google Scholar to find the appropriate databases using Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) Flow Diagram as a clinical information retrieval method. From 1.150.000 results searched by database, there is 73 final results article to
review. The
review shows that P. crocatum contains flavonoids, tannins, terpenes, saponins, polyphenols, eugenol, alkaloids, quinones, chavibetol acetate, glycosides, triterpenoids or steroids, hydroxychavikol, phenolics, glucosides, isoprenoids, and non-protein amino acids. Its antifungal mechanisms in fungal cells occur due to ergosterol, especially lanosterol 14a demethylase (CYP51) inhibition, which is one of the main target sites for antifungal activity because it functions to maintain the integrity and function of cell membranes in Candida. P. crocatum has an antifungal activity through its phytochemical profiling against fungal by inhibiting the lanosterol 14a demethylase, make damaging cell membranes, fungal growth inhibition, and fungal cell lysis.