目标:脂联素,一种由脂肪组织分泌的主要脂肪因子,已被证明可以改善胰岛素敏感性。肌醇六磷酸(肌醇六磷酸;InsP6)是一种天然化合物,在谷物中含量丰富,豆类,和坚果已证明对2型糖尿病患者具有不同的有益特性。
方法:我们进行了一项随机交叉试验,以研究每日摄入InsP6对血清脂联素水平的影响,TNF-α,2型糖尿病(T2DM;n=39)患者的IL-6和IL-1β。因此,我们测量这些炎症标志物的血清水平,经典的血管危险因素,基线和干预期结束时的尿InsP6。
结果:服用InsP6补充剂3个月的患者与不服用InsP6的患者相比,脂联素水平较高,HbA1c较低。在TNF-α中没有发现差异,IL-6和IL-1β。
结论:这是首次报告显示摄入InsP6会增加T2DM患者的血浆脂联素浓度。因此,我们的研究结果表明,富含肌醇六磷酸的饮食对脂联素和HbA1c浓度有有益的影响,并且有助于预防或减少糖尿病相关并发症.
Adiponectin, a major adipokine secreted by adipose tissue, has been shown to improve insulin sensitivity. Myo-inositol hexaphosphate (phytate; InsP6) is a natural compound that is abundant in cereals, legumes, and nuts that has demonstrated to have different beneficial properties in patients with diabetes type 2.
We performed a randomized crossover
trial to investigate the impact of daily consumption of InsP6 on serum levels of adiponectin, TNF-alpha, IL-6, and IL-1beta in patients with type 2 diabetes mellitus (T2DM; n = 39). Thus, we measure serum levels of these inflammatory markers, classic vascular risk factors, and urinary InsP6 at baseline and at the end of the intervention period.
Patients who consumed InsP6 supplements for 3 months had higher levels of adiponectin and lower HbA1c than those who did not consume InsP6. No differences were found in TNF-alpha, IL-6, and IL-1beta.
This is the first report to show that consumption of InsP6 increases plasma adiponectin concentration in patients with T2DM. Consequently, our findings indicate that following a phytate-rich diet has beneficial effects on adiponectin and HbA1c concentrations and it could help to prevent or minimize diabetic-related complications.