Physical health

身体健康
  • 文章类型: Journal Article
    每年仍有越来越多的老年人被拘留,导致越来越多的常见身心健康问题。先前没有基于证据的针对性心理干预措施支持这一群人,对他们的需求知之甚少,当前活动,和健康相关的问题。我们通过一个涉及老年囚犯的项目解决了这些差距,英格兰北部一名男女监狱工作人员和一个项目咨询小组。系统审查证据支持开发一个实施工具包,处理制定和实施可持续干预措施的战略,可接受,在监狱环境中也是可行的。监狱战略需要专门解决被拘留的老年人的需求。相对便宜的活动,有些人认为分娩和灵活性有可能有益于普通的身心健康,提高生活质量,降低高昂的经济和社会成本,死亡率,在这个年龄段再次犯罪。
    A growing number of older people remain in custody each year resulting in an increasing number of common mental and physical health concerns. No prior evidenced-based targeted psychological interventions support this group of people, and little is known about their needs, current activities, and health-related problems. We addressed these gaps through a project involving older prisoners, prison staff and a project advisory group in one male and one female prison site in the North of England. Systematic review evidence supports the development of an implementation tool kit addressing strategies to develop and deliver interventions that are sustainable, acceptable, and feasible in the prison environment. Prison strategies need to specifically address the needs of older people in custody. Relatively inexpensive activities, with some thought to delivery and flexibility have the potential to benefit common mental and physical health, increasing quality of life, reducing high economic and social cost, mortality, and reoffending in this age group.
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  • 文章类型: Journal Article
    人们普遍认为,COVID-19封锁期间日常活动表现的中断影响了健康,但是需要更好地了解特定活动的受限表现如何与健康相关。这项横断面研究回答了以下问题:在COVID-19封锁期间,16项日常活动的表现与健康相关的变化如何?共有116名参与者完成了一项在线调查,对他们在COVID-19封锁之前和期间的健康状况进行了评估,并将他们对COVID-19之前16项活动的表现与封锁期间的表现进行了比较。使用多元逐步线性回归分析来估计封锁期间自我报告的活动变化与同时(封锁期间)健康状况之间的关系。同时控制前COVID-19的健康状况。最终模型中只保留了与锁定健康状况唯一且显著相关的活动变化。COVID-19之前的健康状况占COVID-19封锁期间健康状况差异的3.7%(P=0.039)。在控制COVID-19之前的健康状况后,五种类型的活动对封锁期间的健康状况有显著和独特的预测作用,合计占差异的48.3%。这些活动和它们所占的差异是休息和睡眠(29.5%,P<0.001),游戏和娱乐活动(8%,P<0.001),工作(4.8%,P=0.002),个人卫生(3.2%,P=0.01),和健康饮食(2.8%,P=0.013)。研究表明,当活动的参与受到封锁或类似因素的限制时,应在政策或干预措施中优先考虑这五种类型的活动。
    The disruption in daily activity performance during COVID-19 lockdowns is widely understood to have impacted health, but a better understanding of how restricted performance of specific activities are associated with health is needed. This cross-sectional study answers the following question: How were changes in the performance of 16 daily activities associated with health during COVID-19 lockdowns? A total of 116 participants completed an online survey rating their health before and during COVID-19 lockdowns and comparing their recollection of the performance of 16 activities before COVID-19 with their performance during lockdowns. Multiple stepwise linear regression analysis was used to estimate the relationship between self-reported changes in activities during lockdowns and concurrent (during-lockdown) health status, while controlling for pre-COVID-19 health status. Only changes in activities that were uniquely and significantly associated with lockdown health status were retained in the final model. Health before COVID-19 accounted for 3.7% (P = 0.039) of the variance in health during COVID-19 lockdowns. After controlling for health before COVID-19, five types of activity were significantly and uniquely predictive of health during lockdowns, together accounting for 48.3% of the variance. These activities and the variances they accounted for were rest and sleep (29.5%, P < 0.001), play and recreational activities (8%, P < 0.001), work (4.8%, P = 0.002), personal hygiene (3.2%, P = 0.01), and healthy eating (2.8%, P = 0.013). The study suggests that these five types of activity should be prioritized in policy or interventions when participation in activity is constrained by lockdowns or comparable factors.
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  • 文章类型: Journal Article
    背景:COVID-19大流行对经济、心理,以及埃塞俄比亚人民的社会福祉。与大流行相关的恐惧会加剧那些先前存在身体和精神健康状况以及先前暴露于创伤事件的人的焦虑和抑郁症状。
    方法:我们使用了来自埃塞俄比亚NeuroGAP-精神病研究的数据(分别为898例和941例对照,66%男性,平均年龄=37岁)。数据是在2021年11月至2022年6月COVID-19大流行期间从埃塞俄比亚的四家医院(三家在亚的斯亚贝巴,一家在吉马市)收集的。进行了结构方程模型分析,以检查创伤暴露之间的关联,身体健康状况(如关节炎,神经系统疾病,糖尿病),COVID-19压力,和心理困扰(抑郁和焦虑症状)。我们评估了调解的直接和间接影响,并进行了多组分析,以根据病例控制状况检查适度性。
    结果:我们发现证据表明,更大的创伤暴露和身体健康状况对更高的心理困扰的影响是通过更高的COVID-19压力介导的。社会人口统计学特征(年龄较大和被婚姻)与更高的心理困扰相关,这些关联是通过更大的创伤介导的,身体健康状况,和COVID-19压力。病例控制状态也缓和了这些变量之间的关联,调解效果在案例中更强,在控制中更弱。Further,病例报告了更大的创伤和心理困扰,而对照组报告了更多的身体健康状况和COVID-19压力。
    结论:我们的研究结果独特地评估了埃塞俄比亚等未研究环境中健康和紧急情况相关因素的相互作用。他们强调了包括日常困难和环境压力因素的重要性,以及之前的创伤暴露,作为评估心理健康症状的危险因素。这项研究对心理健康筛查和干预研究具有重要意义,以应对复杂的紧急情况,如埃塞俄比亚,除了COVID-19大流行外,还有武装冲突史。我们的发现可以帮助开发有针对性的服务,以解决具有先前存在的心理和身体健康状况的风险人群的心理健康问题。
    BACKGROUND: The COVID-19 pandemic has profoundly impacted the economic, psychological, and social well-being of people in Ethiopia. Pandemic-related fears can exacerbate anxiety and depression symptoms among those with pre-existing physical and mental health conditions as well as those with prior exposure to traumatic events.
    METHODS: We used data from the Ethiopia NeuroGAP-Psychosis study (898 cases and 941 controls with and without a diagnosis of psychosis respectively, 66% male, mean age = 37 years). Data was collected between November 2021 and June 2022 during the COVID-19 pandemic from four hospitals in Ethiopia (three in Addis Ababa and one in Jimma city). Structural equation modeling analysis was conducted to examine the associations between trauma exposure, physical health conditions (like arthristis, neurological disorders, diabetes), COVID-19 stress, and psychological distress (depression and anxiety symptoms). We assessed direct and indirect effects for mediation, and conducted multigroup analysis to examine moderation by case control status.
    RESULTS: We found evidence that the impact of greater trauma exposure and physical health conditions on higher psychological distress was mediated through higher COVID-19 stress. Sociodemographic characteristics (older age and being maried) were associated with higher psychological distress, with these associations mediated through greater trauma, physical health conditions, and COVID-19 stress. Case-control status also moderated the associations between these variables, with the mediation effects being stronger in cases and weaker in controls. Further, cases reported greater trauma and psychological distress, while controls reported more physical health conditions and COVID-19 stress.
    CONCLUSIONS: Our findings uniquely assess the interaction of health and emergency related factors in understudied settings like Ethiopia. They underscore the importance of including daily hardships and environmental stressors, along with prior trauma exposure, as risk factors for the assessment of mental health symptoms. This study has key implications for mental health screening and intervention research in response to complex emergency contexts like Ethiopia with a history of armed conflict in addition to the COVID-19 pandemic. Our findings can aid the development of targeted services that address the mental health of at-risk groups with pre-existing mental and physical health conditions.
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  • 文章类型: Journal Article
    本研究旨在探讨肩周炎(FS)患者与身心健康相关的生活质量与保守治疗结果之间的相关性。
    这是一项双中心回顾性研究。它包括84名连续接受3个月治疗的患者,包括教育,物理治疗,和皮质类固醇麻醉剂注射。运动范围(ROM)和肩痛和残疾指数(SPADI)评分的变化,在基线和3个月后测量,被选为因变量。年龄数据,性别,身体质量指数,症状持续时间,显性患肢,在基线时收集ShortForm-36(SF-36)分量表,并将其作为预后因素进行调查。使用后向逐步回归模型来识别显著关联。
    在3个月的随访中,所有患者均有明显改善.更高的SF-36一般健康,基线时的心理健康和社会功能评分与ROM和SPADI的更大有益变化相关。相比之下,发现较低的SF-36躯体疼痛和角色情绪评分与更大的改善相关.
    研究结果表明,患者自我感知的身心健康对主观和客观的临床结果都有重大影响,医疗保健专业人员应考虑这些方面。
    预后二级。
    自我感知的精神和身体健康可能会影响受冻结肩影响的受试者的预后。医疗保健提供者应该采用多专业的方法来进行冻结肩康复,将心理学的观点融入到这种状况的管理中。对于受肩周炎影响的人,建议进行超越身体功能的全面评估。
    UNASSIGNED: This study aimed to investigate the correlation between mental and physical health-related quality of life and the outcomes of conservative treatment in patients with frozen shoulder (FS).
    UNASSIGNED: This was a two-center retrospective study. It included 84 consecutive patients who underwent a 3-month treatment comprising education, physical therapy, and corticosteroid-anesthetic injections. Changes in range of motion (ROM) and Shoulder Pain and Disability Index (SPADI) scores, measured at baseline and after 3 months, were selected as dependent variables. Data on age, sex, Body Mass Index, duration of symptoms, dominant affected limb, and Short Form-36 (SF-36) subscales were gathered at baseline and investigated as prognostic factors. Backward stepwise regression models were used to identify significant associations.
    UNASSIGNED: At 3-month follow-up, all the patients showed significant improvement. Higher SF-36 General Health, Mental Health and Social Functioning scores at baseline were associated with a greater beneficial change in ROM and SPADI. In contrast, lower SF-36 Bodily Pain and Role Emotional scores were found to be associated with greater improvement.
    UNASSIGNED: The study findings indicate that the self-perceived mental and physical health of patients have a significant impact on both subjective and objective clinical outcomes and healthcare professionals should take these aspects into account.
    UNASSIGNED: Prognostic Level II.
    Self-perceived mental and physical health could impact the prognosis of subjects affected by frozen shoulder.Healthcare providers should adopt a multi-professional approach to frozen shoulder rehabilitation, integrating the psychological perspective into the management of this condition.For people affected by frozen shoulder, a comprehensive assessment that goes beyond just physical function is recommended.
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  • 文章类型: Journal Article
    背景:在COVID-19大流行期间,社交距离和社交接触减少可能会影响老年人的健康。
    目的:评估社交距离对老年人健康的感知影响,并探讨社交接触与健康结果之间的关系。
    方法:OPAL队列研究的横断面和纵向分析。
    方法:社区居住的老年人。
    方法:我们向现有队列研究的参与者发送了问卷(n=4328)。问题包括社会接触的数量和类型,以及他们经常出去。参与者评估了社交距离对他们健康的影响。社会人口统计学因素和生活质量可从以前的问卷中获得。我们检查了大流行之前和期间的生活质量,并使用逻辑回归分析了社交与健康之间的横截面关系。
    结果:收到3856/4328份问卷(89%)。与大流行前的得分相比,EQ-5D得分变化不大,但25%的参与者报告他们的整体健康状况恶化。电话是最常用的联系方式(78%)。视频通话的使用最少,有35%的参与者不使用它们或无法访问它们。13%的受访者从未外出。较低的接触水平与报告较差健康状况的风险增加相关(赔率(OR)1.04(95%CI1.01-1.08))。那些经历财务压力和在外面花费更少时间的人,报告的风险增加最大,认为整体健康状况恶化。那些报告经济上有压力的人报告健康状况恶化的可能性是那些自称相当舒适的人的4倍(OR4.00(95%CI1.86-8.16))。报告从未外出的参与者报告健康状况恶化的可能性是每天外出的参与者的两倍(OR2.00(95%CI1.57-2.54))。
    结论:与其他人的接触减少与整体健康状况恶化有关。尽管许多老年人报告使用在线技术,比如视频通话,很大一部分人没有使用它们。面临财务压力的老年人更有可能报告健康状况恶化,强调大流行期间社会不平等的影响。少出门也与健康恶化有关。
    BACKGROUND: During the COVID-19 pandemic, social distancing and reduced social contact may have affected older adults\' health.
    OBJECTIVE: To evaluate the perceived impact of social distancing on older adults\' health and explore the association between social contact and health outcomes.
    METHODS: Cross-sectional and longitudinal analyses of the OPAL cohort study.
    METHODS: Community dwelling older adults.
    METHODS: We sent questionnaires to participants of an existing cohort study (n = 4328). Questions included the amount and type of social contact, and how often they went outside. Participants rated the impact of social distancing on their health. Sociodemographic factors and quality of life were available from previous questionnaires. We examined quality of life prior to and during the pandemic and explored the cross-sectional relationship between social contact and health using logistic regression.
    RESULTS: There were 3856/4328 (89%) questionnaires returned. EQ-5D scores changed little compared to pre-pandemic scores but 25% of participants reported their overall health had worsened. The telephone was the most used method of contact (78%). Video calls were used least with 35% of participants not using them or having no access to them. 13% of respondents never went outside. Lower levels of contact were associated with increased risk of reporting worse health (Odds ratio (OR) 1.04 (95% CI 1.01-1.08)). Those experiencing financial strain and who spent less time outside experienced the largest increase in risk of reporting perceived worsened overall health. Those reporting a strain to get by financially were 4 times more likely to report worsened health than those who described themselves as quite comfortably off (OR 4.00 (95% CI 1.86-8.16)). Participants who reported never going outside were twice as likely to report worsened health compared to those who went outside daily (OR 2.00 (95% CI 1.57-2.54)).
    CONCLUSIONS: Less contact with other people was associated with perceived worsening in overall health. Although many older people reported using online technology, such as video calls, a substantial proportion were not using them. Older people facing financial strain were more likely to report worsened health, highlighting the impact of social inequalities during the pandemic. Going outside less was also associated with perceived worsened health.
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  • 文章类型: Journal Article
    背景:鉴于与精神疾病相关的身体健康差异,需要有针对性的生活方式干预,以降低心脏代谢疾病的风险.在年轻人的心理健康治疗中早期整合身体健康对于预防身体合并症至关重要,减少健康差距,管理药物副作用,改善整体健康结果。数字技术越来越多地用于促进健身,生活方式,和一般人群的身体健康。然而,在精神保健中使用这些干预措施来促进身体健康需要对影响其采用和实施的因素有细微差别的理解.
    目的:使用定性设计,我们探索了精神卫生保健专业人员(MHCP)对身体健康的数字技术的态度,目的是阐明机会,发展,和实施有效使用数字工具来促进精神卫生保健中更健康的生活方式。
    方法:使用反身主题分析对MHCP(N=13)进行了半结构化访谈,以探索他们在青年心理健康护理环境中使用数字健康促进身体健康的经验和观点。
    结果:报告了定性分析的三个总体主题:(1)动机会影响实施,(2)患者的准备和能力,(3)重新分配员工角色和职责。其中的次主题,和支持报价,被描述。
    结论:数字手段的使用为改善心理健康护理环境中的身体健康干预措施提供了许多机会。然而,鉴于许多MHCP对这些技术的经验有限,正式培训和额外支持可能会提高实施的可能性。患者症状等因素,安全,和获得技术,以及准备,可接受性,以及MHCP和患者使用数字工具的能力,也必须考虑。此外,必须仔细权衡数据集成的潜在好处与相关风险。
    BACKGROUND: Given the physical health disparities associated with mental illness, targeted lifestyle interventions are required to reduce the risk of cardiometabolic disease. Integrating physical health early in mental health treatment among young people is essential for preventing physical comorbidities, reducing health disparities, managing medication side effects, and improving overall health outcomes. Digital technology is increasingly used to promote fitness, lifestyle, and physical health among the general population. However, using these interventions to promote physical health within mental health care requires a nuanced understanding of the factors that affect their adoption and implementation.
    OBJECTIVE: Using a qualitative design, we explored the attitudes of mental health care professionals (MHCPs) toward digital technologies for physical health with the goal of illuminating the opportunities, development, and implementation of the effective use of digital tools for promoting healthier lifestyles in mental health care.
    METHODS: Semistructured interviews were conducted with MHCPs (N=13) using reflexive thematic analysis to explore their experiences and perspectives on using digital health to promote physical health in youth mental health care settings.
    RESULTS: Three overarching themes from the qualitative analysis are reported: (1) motivation will affect implementation, (2) patients\' readiness and capability, and (3) reallocation of staff roles and responsibilities. The subthemes within, and supporting quotes, are described.
    CONCLUSIONS: The use of digital means presents many opportunities for improving the provision of physical health interventions in mental health care settings. However, given the limited experience of many MHCPs with these technologies, formal training and additional support may improve the likelihood of implementation. Factors such as patient symptomatology, safety, and access to technology, as well as the readiness, acceptability, and capability of both MHCPs and patients to engage with digital tools, must also be considered. In addition, the potential benefits of data integration must be carefully weighed against the associated risks.
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  • 文章类型: Journal Article
    经历基于性别的暴力(GBV)与健康状况有关,这是转诊给运动生理学家的常见适应症。物理治疗师和其他专职卫生专业人员(AHP)。目前尚不清楚AHP识别和应对GBV的准备情况。这项研究旨在确定AHP对经历过GBV的人的反应准备。参与者完成了修改后的医师准备管理亲密伴侣暴力调查(PREMIS)和/或访谈。AHP感到准备不足,感知知识较低,缺乏回应和支持经历过GBV的人的信心,尽管认识到与AHP实践相关的重要性和共识。
    Experiencing gender-based violence (GBV) is associated with health conditions that are common indications for referral to exercise physiologists, physiotherapists and other allied health professionals (AHPs). The readiness of AHPs to identify and respond to GBV is currently unknown. This study aimed to determine the readiness of AHPs to respond to a person who had experienced GBV. Participants completed the modified Physician Readiness to Manage Intimate Partner Violence Survey (PREMIS) and/or an interview. The AHPs felt underprepared, had low perceived knowledge and lacked confidence to respond to and support people who have experienced GBV, despite recognition of the importance and agreement of the relevance to AHPs\' practice.
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  • 文章类型: Journal Article
    背景:体育锻炼可以改善首发精神病(FEP)患者的预后。与最终用户共同设计体育锻炼干预措施有可能增强其可接受性,可行性,和长期生存能力。本研究的目的是使用基于经验的协同设计(EBCD)方法来开发FEP的体育锻炼干预措施,飞行员测试它。
    方法:这项研究是在金奈的精神分裂症研究基金会的FEP项目中进行的,印度。参与者(N=36)是FEP患者及其护理人员,心理健康专业人员(MHP,和体能训练专家。EBCD方法包括一对一访谈,焦点小组讨论,联席会议,和共同设计研讨会。开发了两个教学视频。12名FEP患者在三个月的视频帮助下进行体育锻炼。通过每周的电话和面对面的采访来跟踪他们,以获取有关规律性的数据,频率,锻炼的位置,和舒适水平。
    结果:采访中出现了几个接触点,焦点小组,和联席会议,包括缺乏动力,关于体育锻炼的知识;关于体育锻炼的不同观点;资源有限,和时间限制。两个演示参与者活动的教学视频纳入了解决这些接触点的策略。试点数据表明,参与者参与体育锻炼干预超过3个月。
    结论:这是第一项使用共同设计方法设计针对首发精神病的体育锻炼干预措施的研究。因此,干预可能是对利益攸关方的需求和偏好的回应。这项研究的结果突出了共同设计在设计和适应干预措施方面的潜力。需要用更大的样品进行严格的测试。
    BACKGROUND: Physical exercise can improve outcomes for people with first-episode psychosis (FEP). Co-designing physical exercise interventions with end users has the potential to enhance their acceptability, feasibility, and long-term viability. This study\'s objective was to use experience-based co-design (EBCD) methodology to develop a physical exercise intervention for FEP, and pilot test it.
    METHODS: The study was conducted at the Schizophrenia Research Foundation\'s FEP program in Chennai, India. Participants(N=36) were individuals with FEP and their caregivers, mental health professionals (MHPs, and physical training experts. EBCD methodology included one-to-one interviews, focus group discussions, joint conferences, and co-design workshops. Two instructional videos were developed. Twelve FEP patients engaged in physical exercise with help of the videos over three months. They were followed up through weekly phone calls and in-person interviews to capture data on regularity, frequency, location of exercise, and comfort levels.
    RESULTS: Several touch points emerged from the interviews, focus groups, and joint meetings including lack of motivation, knowledge about physical exercise; differing perspectives about physical exercise; limited resource, and time constraints. Two instructional videos demonstrating activities for participants incorporated strategies that addressed these touch points. Pilot data indicated that participants engaged with the physical exercise intervention over 3 months.
    CONCLUSIONS: This was the first study to use co-design methodology to design a physical exercise intervention for first-episode psychosis. The intervention may have therefore been responsive to stakeholder needs and preferences. Results of this study highlight the potential of co-design in designing and adapting interventions. There is need for rigorous testing with larger samples.
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  • 文章类型: Journal Article
    背景:在数字时代,数字素养是衡量一个国家素质的基本指标,在公共卫生中起着至关重要的作用。探索数字素养对个人健康的理论机制和影响具有重要的现实意义。推进“数字中国”和“健康中国”的举措。
    方法:该研究利用了2016年,2018年和2020年中国家庭小组研究的三个阶段的调查面板数据来衡量和评估数字素养水平。身体健康,心理健康,健康的生活方式,以及参与者之间的综合健康。随后,进行了一系列实证分析,以检验其总体影响,数字素养对各类健康水平的异质性影响和传播途径。
    结果:数字素养显着增强了受访者的各个方面健康,并且这一结论即使在进行了稳健性检验并通过变量替代解决内生性问题以及使用2SLS方法选择工具变量后仍然有效。此外,通过考虑个人特征和数字素养的构成来检查异质性,这表明数字素养对个人健康的影响因年龄而异,文化背景,个人收入,以及数字素养的组成部分。路径分析还表明,医疗可及性,信息访问,社交网络,和有计划的行为是数字素养增强人口健康的关键途径。
    结论:政府必须积极推动数字医疗产业的发展,而个人应该努力提高他们的数字素养。通过集体关注这些努力,国民健康可以显著改善。
    BACKGROUND: In the digital era, digital literacy is a fundamental indicator of a nation\'s quality and plays a crucial role in public health. Exploring the theoretical mechanisms and effects of digital literacy on individuals\' health is of great practical importance, advancing the initiatives of \'Digital China\' and \'Healthy China\'.
    METHODS: The study utilised three-period survey panel data from the China Family Panel Study spanning 2016, 2018, and 2020 to measure and evaluate levels of digital literacy, physical health, mental health, healthy lifestyle, and integrated health among the participants. Subsequently, a series of empirical analyses were conducted to examine the general impact, heterogeneous effects and transmission pathways of digital literacy on various types of health levels.
    RESULTS: Digital literacy significantly enhances all aspects of respondents\' health, and this conclusion remains valid even after conducting robustness tests and addressing endogeneity through variable substitution and selecting instrumental variables using the 2SLS method. Furthermore, examining heterogeneity by considering individual traits and the makeup of digital literacy reveals that the impact of digital literacy on individuals\' health varies according to age, cultural background, personal income, and the components of digital literacy. Pathway analyses also demonstrate that medical accessibility, information access, social network, and planned behaviour are key routes through which digital literacy enhances the health of the population.
    CONCLUSIONS: It is imperative for the government to actively promote the advancement of the digital healthcare industry, while individuals should strive to enhance their digital literacy. By collectively focussing on these efforts, national health can be significantly improved.
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  • 文章类型: Journal Article
    背景:性功能障碍是许多成人发病的癌症治疗的重要并发症。然而,对成年儿童癌症幸存者(CCSs)性功能障碍的了解相对较少。研究受到排除特定癌症的限制(例如,中枢神经系统[CNS]肿瘤)和缺乏有效的措施,这使得很难理解CCS中性功能障碍的性质和患病率。
    方法:共有249名成人CCS(18-65岁)参加了REACH项目,前瞻性队列研究,并完成了身心健康措施,包括性功能障碍.女性性功能指数6得分≤19或国际勃起功能指数5得分≤21的参与者被归类为性功能障碍。分析了性功能障碍与人口统计学之间的关系,疾病,治疗,和健康变量。
    结果:共有78名参与者(32%)经历了临床上显著的性功能障碍。在单变量分析中,性功能障碍与中枢神经系统肿瘤诊断显著相关(比值比[OR],2.56)和手术(OR,1.96)以及疲劳等健康变量(OR,3.00),睡眠不足(或,2.84),疼痛(或,2.04),抑郁症(或,2.64),身体健康状况不佳(或,2.45),和不良的心理健康(或者,2.21).调整后的分析发现,中枢神经系统肿瘤诊断(p=.001)和健康变量(p=.025)对CCS中的性功能障碍有重要贡献。
    结论:大约三分之一的成人CCS报告临床上显著的性功能障碍,这强调了重大的筛查和治疗需求。然而,因为针对成人癌症幸存者制定了可用的措施,有必要进行专门针对成人CCS的性健康措施的研究,以更好地识别该弱势群体的性健康问题。
    BACKGROUND: Sexual dysfunction is a significant complication of treatment for many adult-onset cancers. However, comparatively less is known about sexual dysfunction in adult childhood cancer survivors (CCSs). Research has been limited by the exclusion of specific cancers (e.g., central nervous system [CNS] tumors) and the lack of validated measures, which makes it difficult to understand the nature and prevalence of sexual dysfunction in CCSs.
    METHODS: A total of 249 adult CCSs (aged 18-65 years) enrolled in Project REACH, a prospective cohort study, and completed measures of physical and mental health, including sexual dysfunction. Participants scoring ≤19 on the Female Sexual Function Index 6 or ≤21 on the International Index of Erectile Function 5 were classified as experiencing sexual dysfunction. Analyses examined the relationships between sexual dysfunction and demographic, disease, treatment, and health variables.
    RESULTS: A total of 78 participants (32%) experienced clinically significant sexual dysfunction. In univariate analysis, sexual dysfunction was significantly associated with CNS tumor diagnosis (odds ratio [OR], 2.56) and surgery (OR, 1.96) as well as with health variables such as fatigue (OR, 3.00), poor sleep (OR, 2.84), pain (OR, 2.04), depression (OR, 2.64), poor physical health (OR, 2.45), and poor mental health (OR, 2.21). Adjusted analyses found that CNS tumor diagnosis (p = .001) and health variables (p = .025) contribute significantly to sexual dysfunction in CCSs.
    CONCLUSIONS: Approximately one third of adult CCSs report clinically significant sexual dysfunction, which underscores a significant screening and treatment need. However, because available measures were developed for survivors of adult cancers, research to create a sexual health measure specifically for adult CCSs is necessary to better identify the sexual health concerns of this vulnerable population.
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