炎症性肠病（IBD），包括克罗恩病（CD）和溃疡性结肠炎（UC），被称为慢性胃肠道炎症性疾病。进行了本系统综述和荟萃分析，以评估与对照组相比，IBD患者中粘附性侵袭性大肠杆菌（AIEC）分离株的患病率及其系统发育分组。在2020年4月30日之前在WebofScience上对国际作者发表的论文进行了系统的文献检索，Scopus,EMBASE,和PubMed数据库。使用固定或随机效应模型估计了IBD患者以及对照组中AIEC分离株的合并患病率及其系统发育分组。此外，用于估计AIEC定殖与IBD的关联，报告了比值比和95%置信区间.初步检索数据库共检索到205篇文章,13项病例对照研究符合纳入荟萃分析的资格标准。有465例IBD病例（348例CD和117例UC）和307例对照。AIEC分离株的合并患病率为28%(95%CI:18-39%)，29%（95%CI：20-40%），13%（95%CI：1-30%），和9%（95%CI：3-19%），分别在IBD中，CD,UC,和对照组，分别。我们的结果显示，IBD中最常见的AIEC系统组，CD,对照组为B2。固定效应荟萃分析表明，AIEC的定植与IBD（OR：2.93；95％CI：1.90-4.52；P<0.001）和CD（OR：3.07；95％CI：1.99-4.74；P<0.001）显着相关，但与UC无关（OR：2.29；95％CI：0.81-6.51；P=0.11）。总之,这项荟萃分析显示,AIEC定植在IBD中更为频繁,并且与IBD(CD和UC)相关.我们的结果表明，IBD对AIEC病理改变的患者的影响不是随机的，事实上，这是一种与疾病有关的特定病理。
Inflammatory bowel diseases (IBD), including Crohn\'s disease (CD) and ulcerative colitis (UC), are known as chronic gastrointestinal inflammatory disorders. The present systematic
review and meta analysis was conducted to estimate the prevalence of adherent-invasive Escherichia coli (AIEC) isolates and their phylogenetic grouping among IBD patients compared with the controls. A systematic literature search was conducted among published papers by international authors until April 30, 2020 in Web of Science, Scopus, EMBASE, and PubMed databases. The pooled prevalence of AIEC isolates and their phylogenetic grouping among IBD patients as well as in controls was estimated using fixed or random effects models. Furthermore, for estimating the association of colonization by AIEC with IBD, odds ratio along with 95% confidence interval was reported. A total of 205 articles retrieved by the initial search of databases, 13 case-control studies met the eligibility criteria for inclusion in the meta analysis. There were 465 IBD cases (348 CD and 117 UC) and 307 controls. The pooled prevalence of AIEC isolates were 28% (95% CI: 18-39%), 29% (95% CI: 20-40%), 13% (95% CI: 1-30%), and 9% (95% CI: 3-19%), respectively among IBD, CD, UC, and control group, respectively. Our results revealed that the most frequent AIEC
phylogroup in the IBD, CD, and control groups was B2. Fixed-effects meta analysis showed that colonization of AIEC is significantly associated with IBD (OR: 2.93; 95% CI: 1.90-4.52; P < 0.001) and CD (OR: 3.07; 95% CI: 1.99-4.74; P < 0.001), but not with UC (OR: 2.29; 95% CI: 0.81-6.51; P = 0.11). In summary, this meta analysis revealed that colonization by AIEC is more frequent in IBD and is associated with IBD (CD and UC). Our results suggested that the affects of IBD in patients colonized with the AIEC pathovar is not random, it is in fact a specific disease-related pathovar.
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