小核仁RNA宿主基因8(SNHG8)是一种长非编码RNA,在上皮和肌肉卫星细胞中具有生理作用。据报道,这种lncRNA在多种癌细胞系中过度表达。它的沉默已经减弱了癌症动物模型中的肿瘤生长。SNHG8可以作为一些miRNA的分子海绵来调节它们的靶基因。miR-634/ZBTB20,miR-335-5p/PYGO2,miR588/ATG7,miR-152/c-MET,miR-1270/BACH1,miR-491/PDGFRA,miR-512-5p/TRIM28,miR-149-5p/PPM1F,miR-542-3p/CCND1/CDK6、miR-656-3p/SERBP1、miR-656-3p/SATB1、miR-1270/S100A11和miR-384/HOXB7是在癌症背景下由SNHG8调控的分子轴的实例。此外,它可以影响动脉粥样硬化的发病机制,慢性脑缺血,急性痛风性关节炎,通过调节SNHG8/miR-384/Hoxa13/FAM3A和miR-335/RASA1等分子轴以及NF-κB信号通路来实现缺血性卒中和心肌梗死。本综述旨在总结SNHG8在各种人类疾病中的作用。
Small nucleolar RNA host gene 8 (SNHG8) is a long non-coding RNA that has physiological roles in epithelial and muscle satellite cells. This lncRNA has been reported to be over-expressed in a variety of cancer cell lines. Its silencing has attenuated tumor growth in animal models of cancers. SNHG8 can be served as a molecular sponge for some miRNAs to regulate their target genes. miR-634/ZBTB20, miR-335-5p/PYGO2, miR588/ATG7, miR-152/c-MET, miR-1270/BACH1, miR-491/PDGFRA, miR-512-5p/TRIM28, miR-149-5p/PPM1F, miR-542-3p/CCND1/CDK6, miR-656-3p/SERBP1, miR-656-3p/SATB1, miR-1270/S100A11 and miR-384/HOXB7 are examples of molecular axes being regulated by SNHG8 in the context of cancer. Moreover, it can affect pathogenesis of atherosclerosis, chronic cerebral ischemia, acute gouty arthritis, ischemic stroke and myocardial infarction through modulation of a number of molecular axes such as SNHG8/miR-384/Hoxa13/FAM3A and miR-335/RASA1 as well as NF-κB signaling pathway. The current
review aims at summarization of the role of SNHG8 in diverse human disorders.