聚乙二醇化重组人粒细胞集落刺激因子(PEG-rhG-CSF)已被引入用于动员外周血干细胞(PBSC)。然而,没有健康供体急性肺损伤(ALI)的报道,和潜在的机制仍然知之甚少。我们首次报道了一例健康中国供体中PEG-rhG-CSF引起的ALI,以咯血为特征,低氧血症,和零散的阴影。最终,激素给药,计划的PBSC收集,白细胞清创术,和计划的PBSC收集导致对捐赠者的ALI的主动控制。捐献者的症状有所改善,没有任何不良反应,并且PBSC收集没有发生任何事件。随着时间的推移,肺部病变逐渐吸收,最终恢复正常。PEG-rhG-CSF可能通过涉及中性粒细胞聚集的机制促进健康供体的ALI,附着力,以及肺部炎症介质的释放。该病例报告检查了临床表现,治疗,PEG-rhG-CSF动员PBSCs诱导肺损伤的机制。
Pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) has been introduced for the mobilization of peripheral blood stem cells (PBSCs). However, no cases of acute lung injury (ALI) in healthy donors have been reported, and the underlying mechanisms remain poorly understood. We first reported a
case of ALI caused by PEG-rhG-CSF in a healthy Chinese donor, characterized by hemoptysis, hypoxemia, and patchy shadows. Ultimately, hormone administration, planned PBSC collection, leukocyte debridement, and planned PBSC collection resulted in active control of the donor\'s ALI. The donor\'s symptoms improved without any adverse effects, and the PBSC collection proceeded without incident. Over time, the lung lesion was gradually absorbed and eventually returned to normal. PEG-rhG-CSF may contribute to ALI in healthy donors via mechanisms involving neutrophil aggregation, adhesion, and the release of inflammatory mediators in the lung. This
case report examines the clinical manifestations, treatment, and mechanism of lung injury induced by PEG-rhG-CSF-mobilized PBSCs.