本研究探讨了不同浓度PCP对胎儿长期心动过缓风险的系统评价和荟萃分析。
Cochrane图书馆,Embase,PubMed,中国生物医学文献服务,CNCNKI,和万方数据库进行了计算机化,以收集有关品种类别与不同浓度的环境污染物气体与长期心动过缓胎儿之间关系的所有病例对照研究。在评估纳入研究的质量并提取有效数据后,使用Stata15软件进行荟萃分析。使用Mantel-Haenszel方法和随机效应模型计算相对危害,P值和I2值用于异质性评价。当异质性发生时,采用亚组分析和敏感性分析探讨来源.
共纳入15项研究,包括1202例胎儿心动过缓患者和1380例对照人群。Meta分析结果显示,实验组与对照组PCP<0.1mg/L差异无统计学意义(OR=1.03,95%CI(0.62,1.72),P=0.90,I2=0%,Z=0.13),但PCP>5mg/L有统计学差异(OR=1.73,95%CI(1.15,2.58),P=0.008,I2=0%,Z=2.65),PCP>10mg/L(OR=1.75,95%CI(1.19,2.57),P=0.004,I2=14%,Z=2.85),PCP>15毫克/升(OR=2.02,95%CI(1.38,2.95),P=0.0003,I2=77%,Z=3.61)。
在这项研究中,我们发现不同浓度的PCP会增加胎儿长期心动过缓的风险,危险系数随PCP浓度的增加而增加。
This study explored the systematic evaluation and meta-analysis of different concentrations of PCP on the risk of long-term bradycardia in fetuses.
Cochrane Library, Embase, PubMed, China Biomedical Literature Service, CNCNKI, and Wanfang database were computerized to collect all case-control studies on the association between variety classes and different concentrations of environmental pollutant gas to fetal of prolonged bradycardia. After evaluating the quality of the inclusion study and extracting valid data, meta-analysis was performed using Stata15 software. Relative hazards were calculated using the Mantel-Haenszel method and the random effect model, and P values and I 2 values were used for heterogeneity evaluation. When heterogeneity occurs, subgroup analysis and sensitivity analysis were used to explore the sources.
A total of 15 studies were included, including 1202 patients with fetal of prolonged bradycardia and 1380 in the control population. Meta-analysis showed that there was no statistical difference in PCP < 0.1 mg/L between the experimental group and control group (OR = 1.03, 95% CI (0.62, 1.72), P=0.90, I 2 = 0%, Z = 0.13), but there was a statistical difference in PCP > 5 mg/L (OR = 1.73, 95% CI (1.15, 2.58), P=0.008, I 2 = 0%, Z = 2.65), PCP > 10 mg/L (OR = 1.75, 95% CI (1.19, 2.57), P=0.004, I 2 = 14%, Z = 2.85), and PCP >15 mg/L (OR = 2.02, 95% CI (1.38, 2.95), P=0.0003, I 2 = 77%, Z = 3.61).
In this study, we found that different concentrations of PCP increased the risk of long-term bradycardia in fetuses, and the risk coefficient increased with the increase of PCP concentration.