发育中的中枢神经系统容易受到多种刺激,尤其是精神药物。在小儿重症监护病房(PICU)中,发育期的镇静程序很常见,其中镇静剂的使用对于PICU团队仍然是一个挑战。氯胺酮已用于血液动力学和通气不稳定的危重患儿的镇静。但是与这种使用相关的可能的神经行为后果仍然不确定。这里,我们使用常规指标进行了文献计量学分析,并对临床研究结果进行了严格审查,以揭示文献中值得进一步研究的差距.我们发现,只有56篇文章符合研究的纳入标准。美利坚合众国成为本次审查范围内的主要国家。此外,专业临床学会在通过专业期刊发表科学临床发现方面发挥关键作用,鼓励分享研究工作。关键词的同时出现证明了术语“镇静”,\"氯胺酮\",和“儿科”是最常见的。病例系列和综述文章是最普遍的研究设计。在批判性评估中,稀缺的研究强调了使用和使用后监测的必要性,这加强了其他强有力的临床研究的重要性,以表征氯胺酮麻醉方案在危重患儿中可能产生的不良反应。
The developing central nervous system is vulnerable to several stimuli, especially psychotropic drugs. Sedation procedures during the developmental period are frequent in pediatric intensive care units (PICUs), in which the use of the sedative agent is still a challenge for the PICU team. Ketamine has been indicated for sedation in critically ill children with hemodynamic and ventilatory instabilities, but the possible neurobehavioral consequences related to this use are still uncertain. Here, we performed a bibliometric analysis with conventional metrics and a critical
review of clinical findings to reveal a gap in the literature that deserves further investigation. We revealed that only 56 articles corresponded to the inclusion criteria of the study. The United States of America emerges as the main country within the scope of this
review. In addition, professional clinical societies play a key role in the publications of scientific clinical findings through the specialist journals, which encourages the sharing of research work. The co-occurrence of keywords evidenced that the terms \"sedation\", \"ketamine\", and \"pediatric\" were the most frequent. Case series and
review articles were the most prevalent study design. In the critical evaluation, the scarce studies highlight the need of use and post-use monitoring, which reinforces the importance of additional robust clinical studies to characterize the possible adverse effects resulting from ketamine anesthetic protocol in critically ill children.