这里,我们使用5例说明性临床病例总结了目前有关Arah6致敏的临床知识和这种致敏模式的临床相关性.文献检索共发表论文166篇,“滚雪球”发现了另一篇相关文章。共有十篇文章被认为与本评论相关。大多数研究包括对Arah6敏感和对Arah2共敏的患者。只有三项研究显示患者对Arah6单敏。这说明Arah6单敏化在文献中被忽略。我们介绍了一系列对花生成分Arah6敏感的5名儿童。这5例患者中只有1例表现出Arah8共敏感性。五个孩子中有三个双盲安慰剂对照食物挑战(DBPCFC)呈阳性,有中等到强烈的反应。
结论:对花生成分Arah6的单一致敏作用并不常见,但可引起严重的过敏反应。因此,在怀疑花生过敏的患者中,对Arah6的sIgE测定是有保证的,特别是在没有对Arah1、2、3和9敏感的情况下。
背景:•花生过敏很常见,可引起严重的过敏反应。•花生过敏的诊断最近随着成分解决诊断的使用而得到了改善。什么是新的:•对花生成分Arah6的单敏作用并不常见,但可能引起严重的过敏反应•怀疑花生过敏的患者必须测定对Arah6的sIgE,特别是在没有对Arah1、2、3和9敏感的情况下。
Here, we summarise the current clinical knowledge on Ara h 6 sensitisation and clinical relevance of this sensitisation pattern using five illustrative clinical cases. The literature search yielded a total of 166 papers, and an additional relevant article was found by \'snowballing\'. A total of ten articles were considered relevant for this review. Most studies included patients with a sensitisation to Ara h 6 and cosensitisation to Ara h 2. Only three studies showed patients with a mono-sensitisation to Ara h 6. This illustrates that Ara h 6 mono-sensitisation has been neglected in literature. We present a
case series of five children with sensitisation to peanut component Ara h 6. Only one of these five patients showed Ara h 8 cosensitivity. Three out of the five children had a positive double-blind placebo-controlled food challenge (DBPCFC), with moderate to strong reactions.
CONCLUSIONS: A mono-sensitisation to peanut component Ara h 6 is uncommon but can cause severe allergic reactions. Therefore, the determination of sIgE to Ara h 6 is warranted in patients with a suspected peanut allergy, especially in the absence of sensitisation to Ara h 1, 2, 3 and 9.
BACKGROUND: • Peanut allergy is common and can cause severe allergic reactions. • The diagnostics of peanut allergy has recently improved with the use of component resolved diagnosis What is new: • A mono-sensitisation to peanut component Ara h 6 is uncommon, but can cause severe allergic reactions • Determination of sIgE to Ara h 6 is warranted in patients with a suspected peanut allergy, especially in the absence of sensitisation to Ara h 1, 2, 3 and 9.