为了无偏见地比较不同的辐射方式和技术,有必要就放射敏感器官(OAR)的划分及其剂量限制达成共识.在数字发布之后,同一组在神经肿瘤学中进行OAR描绘的在线地图集,我们在一项随访研究中评估了大脑OAR剂量限制.
我们进行了全面的搜索,以确定PubMed中有关OAR剂量限制的最新论文,OvidMedline,科克伦图书馆,Embase和WebofScience。此外,纳入的文章参考列表对符合纳入标准的潜在研究进行交叉检查.神经肿瘤学领域的20位放射肿瘤学专家达成了共识。
对于神经肿瘤学文献中发表的OAR,根据最近的ICRU建议,我们总结了现有文献和与某些正常组织并发症概率(NTCP)水平相关的推荐剂量限制.对于NTCP数据缺乏或不足的OAR,提出了有效和高效的数据收集建议。
本文中总结的欧洲粒子治疗网络共识OAR剂量限制的使用推荐用于基于模型的方法比较光子和质子束辐照以及包括新的辐射技术和/或模式的前瞻性临床试验。
For unbiased comparison of different radiation modalities and techniques,
consensus on delineation of radiation sensitive organs at risk (OARs) and on their dose constraints is warranted. Following the publication of a digital, online atlas for OAR delineation in neuro-oncology by the same group, we assessed the brain OAR-dose constraints in a follow-up study.
We performed a comprehensive search to identify the current papers on OAR dose constraints for normofractionated photon and particle therapy in PubMed, Ovid Medline, Cochrane Library, Embase and Web of Science. Moreover, the included articles\' reference lists were cross-checked for potential studies that met the inclusion criteria.
Consensus was reached among 20 radiation oncology experts in the field of neuro-oncology.
For the OARs published in the neuro-oncology literature, we summarized the available literature and recommended dose constraints associated with certain levels of normal tissue complication probability (NTCP) according to the recent ICRU recommendations. For those OARs with lacking or insufficient NTCP data, a proposal for effective and efficient data collection is given.
The use of the European Particle Therapy Network-
consensus OAR dose constraints summarized in this article is recommended for the model-based approach comparing photon and proton beam irradiation as well as for prospective clinical trials including novel radiation techniques and/or modalities.