最近对肝脏阶段疟疾寄生虫-宿主相互作用的研究为寄生虫与其哺乳动物(主要是啮齿动物)宿主之间的串扰提供了令人兴奋的新见解。我们回顾了最新的最新技术,并放大了新技术,这些技术将为研究复发性寄生虫的宿主-寄生虫相互作用提供必要的工具。催生子和肝细胞之间的相互作用特别有趣,因为寄生虫可以长时间保持静止状态,并且尚未确定重新激活的触发因素。如果我们了解更多关于催眠体和宿主之间的交叉对话,我们可能能够确定鼓励唤醒这些休眠寄生虫库并帮助实现彻底根除疟疾的因素。
Recent studies of liver stage malaria parasite-host interactions have provided exciting new insights on the cross-talk between parasite and its mammalian (predominantly rodent) host. We review the latest state of the art and and zoom in on new technologies that will provide the tools necessary to investigate host-parasite interactions of relapsing parasites. Interactions between hypnozoites and hepatocytes are particularly interesting because the parasite can remain in a quiescent state for prolonged periods of time and triggers for reactivation have not been irrefutably identified. If we learn more about the cross-talk between hypnozoite and host we may be able to identify factors that encourage waking up these dormant parasite reservoirs and help to achieve the total eradication of malaria.