Paraphilic Disorders

Parphilic Disorders
  • 文章类型: Journal Article
    适应不良的人格特质,例如“黑暗人格”被发现会导致一系列不同的负面结果,包括亲热利益和相关(非法)行为。然而,目前还不清楚这些到底是如何相关的,如果相关,如果只有那些在黑暗人格特质和冲动性较高的个体参与亲热行为。在目前的研究中,招募了50名参与者来调查DarkTetrad人格特质之间的关系(即,自恋,精神病,马基雅维利主义和日常虐待狂),副反应性兴趣(唤醒和行为)和冲动性的调节作用。通过自我报告问卷调查了人格和异性恋兴趣。在Go/No-Go任务期间使用脑电图通过自我报告的功能失调冲动性和P3事件相关电位(即反应抑制)来测量冲动性。结果显示,精神病之间存在正相关,虐待狂和亲热的利益。而日常施虐与亲热(自我报告)唤醒有关,精神病与性交行为有关。尽管P3振幅与亲热兴趣无关,自我报告的功能失调性冲动与亲缘行为特别相关。然而,在精神病与性交行为之间的关系中,功能失调的冲动性和反应抑制(P3)没有调节作用。研究结果表明,特定的黑暗人格与亲民兴趣之间的关系可能比最初认为的要复杂得多。然而,对亲热症和相关行为的风险评估和干预方法都可能受益于纳入DarkTetrad和冲动性测量。
    Maladaptive personality traits, such as \'dark personalities\' are found to result in a diverse set of negative outcomes, including paraphilic interests and associated (illegal) behaviors. It is however unclear how these are exactly related, and if related, if then only those individuals higher on dark personality traits and higher impulsivity engage in paraphilic behaviors. In the current study, 50 participants were recruited to investigate the relationship between Dark Tetrad personality traits (i.e., narcissism, psychopathy, Machiavellianism and everyday sadism), paraphilic interests (arousal and behavior) and the moderating role of impulsivity. Personality and paraphilic interests were investigated through self-report questionnaires. Impulsivity was measured both through self-reported dysfunctional impulsivity and the P3 event related potential using electroencephalography during the Go/No-Go task (i.e. response inhibition). The results showed that there was a positive association between psychopathy, sadism and paraphilic interests. Whereas everyday sadism was associated with paraphilic (self-reported) arousal, psychopathy was associated with paraphilic behavior. Although P3 amplitude was not associated with paraphilic interests, self-reported dysfunctional impulsivity was associated with paraphilic behavior specifically. However, there was no moderating role of dysfunctional impulsivity and response inhibition (P3) in the relationship between psychopathy and paraphilic behavior. Findings indicate that the relation between specific dark personalities and paraphilic interests may be more complex than initially thought. Nevertheless, risk assessment and intervention approaches for paraphilia and related behavior both may benefit from incorporating Dark Tetrad and impulsivity measurements.
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  • 文章类型: Journal Article
    目标:2007年,纽约颁布了《性犯罪者管理和治疗法》,授权国家对犯有性犯罪(受访者)并被认为具有精神异常(MA)的个人进行民事管理,使他们在服刑事判决后容易性再犯。我们试图复制和扩展先前的研究(Lu等人。,2015)确定预测法律决定的因素。
    目标:我们预测,在前人研究的基础上,该临床信息(例如,诊断)以及经验支持的风险因素(例如,性偏差)将预测试验结果。
    方法:我们分析了多个人口统计,犯罪,以及基于法律程序的三个嵌套子样本的临床数据:MA同意(n=713),MA试验(n=316),和处置听证(n=643)。感兴趣的二元结果如下:对于MA同意子样本,是受访者是否放弃了他们的MA试验;对于MA试验子样本,是在审判中是否发现被告有MA;对于处置听证会,问题是被告是否被命令住院或门诊民事管理。
    结果:放弃试验的最强预测因素是地理位置;纽约市和长岛以外的受访者更有可能放弃试验(ORs=2.38-3.37)。MA试验和处置听力结果的最强预测因子是精神障碍诊断和统计手册;恋童癖(ORs=4.05-7.22)和性施虐(ORs=2.68-7.03)的诊断增加了MA发现和禁闭顺序的可能性。
    结论:法官和陪审团非常重视临床信息,特别是恋童癖的诊断,在做出民事管理法律决定时。(PsycInfo数据库记录(c)2024APA,保留所有权利)。
    OBJECTIVE: In 2007, New York enacted the Sex Offender Management and Treatment Act, empowering the state to civilly manage individuals who have committed sexual offenses (respondents) and are deemed to have a mental abnormality (MA) that predisposes them to sexually recidivate after serving their criminal sentences. We sought to replicate and extend a previous study (Lu et al., 2015) to identify factors predicting legal decisions.
    OBJECTIVE: We predicted, on the basis of previous research, that clinical information (e.g., diagnosis) as well as empirically supported risk factors (e.g., sexual deviance) would predict trial outcomes.
    METHODS: We analyzed multiple pieces of demographic, criminogenic, and clinical data on three nested subsamples of respondents on the basis of the legal process: MA consent (n = 713), MA trial (n = 316), and disposition hearing (n = 643). The binary outcomes of interest were as follows: For the MA consent subsample, it was whether the respondent waived their MA trial; for the MA trial subsample, it was whether the respondent was found at trial to have an MA; and for the disposition hearing, it was whether the respondent was ordered to inpatient or outpatient civil management.
    RESULTS: The strongest predictor of waiving the trial was geographic location; respondents outside New York City and Long Island were more likely to waive their trials (ORs = 2.38-3.37). The strongest predictors of MA trial and disposition hearing outcomes were Diagnostic and Statistical Manual of Mental Disorders diagnoses; pedophilia (ORs = 4.05-7.22) and sexual sadism (ORs = 2.68-7.03) diagnoses increased the likelihood of an MA finding and confinement order.
    CONCLUSIONS: Judges and juries give significant weight to clinical information, particularly pedophilia diagnoses, when making civil management legal decisions. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
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  • 文章类型: Case Reports
    这是对近一个半世纪以来儿童和青少年发生的21起连环性谋杀案的描述性研究。没有发现全球早期病例。这些年轻人中的每个人在18岁之前都犯下了两次或更多次性杀人罪。他们的精神病理学,社会心理,犯罪现场行为,并提出了罪犯-受害者关系的特征。此外,解决了性施虐的作用及其使用SADSEX-SH评定量表的测量。几乎所有的样本都有行为障碍,亲合性障碍,和虐待狂的幻想,三分之二的人有性虐待障碍。家庭功能障碍,严重的学校问题,和平均或以上的智商水平是典型的。他们的作案手法通常反映了掠夺性行为,而直接接触的杀戮方法最为常见。提供了两份案例报告来说明这些罪犯的广度和复杂性。青少年连环性杀人是一种极为罕见但持久的现象。讨论了预后意义和未来的研究方向。
    This is a descriptive study of 21 cases of serial sexual murder by children and adolescents spanning nearly the past century and a half. No earlier cases worldwide were identified. Each of these youth committed two or more sexual homicides prior to age 18. Their psychopathological, psychosocial, crime scene behaviors, and offender-victim relationship characteristics are presented. Additionally, the role of sexual sadism and its measurement using the SADSEX-SH rating scale is addressed. Nearly all of the sample had conduct disorder, a paraphilic disorder, and sadistic fantasies, and two-thirds had sexual sadism disorder. Family dysfunction, serious school problems, and average or above IQ levels were typical. Their modus operandi generally reflected predatory behavior and direct contact methods of killing were most common. Two case reports are provided to illustrate the breadth and complexity of these offenders. Juvenile Serial Sexual Homicide is an extremely rare but persistent phenomenon. Prognostic implications and future research directions are discussed.
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  • 文章类型: Journal Article
    有关香港性侵犯的患病率和性质的资料有限。这项横断面研究旨在探讨危险性行为(RSB)和性交兴趣在自我报告的性犯罪行为中的作用(即,只有非穿透性,仅穿透性,和非穿透性加穿透性性侵犯)在香港的年轻人社区样本中。使用大样本(N=1885)的大学生,自我报告的性侵犯的终生患病率为18%(n=342;23%的男性(n=166),15%女性(n=176)。根据342名自我报告性犯罪的参与者(18-35岁)的研究子样本,研究结果表明,男性报告的一般水平明显更高,仅穿透性,非穿透性加穿透性的性侵犯;以及对偷窥狂的兴趣,frotteurism,生物嗜血杆菌,scarophilia,和hebephilia高于女性;而女性报告的变体恋物癖的水平明显高于男性。RSB在男性和女性之间没有发现显着差异。Logistic回归发现,具有较高RSB水平的参与者,特别是渗透行为,对偷窥狂和动物嗜好的嗜好者不太可能参与非穿透性的性犯罪。相反,拥有较高水平RSB的参与者,尤其是穿透性行为,以及对暴露狂和动物嗜好的嗜好,更有可能参与非穿透性加穿透性的性侵犯。讨论了公共教育和罪犯康复等领域对实践的影响。
    Limited information is available on the prevalence and nature of sexual offending in Hong Kong. This cross-sectional study seeks to explore the role of risky sexual behavior (RSB) and paraphilic interests in self-reported sexual offending behavior (i.e., nonpenetrative-only, penetrative-only, and nonpenetrative-plus-penetrative sexual assault) in a community sample of young adults in Hong Kong. Using a large sample (N = 1885) of university students, the lifetime prevalence of self-reported sexual offending was 18% (n = 342; 23% males (n = 166), 15% females (n = 176)). Based on the study subsample of 342 participants who self-reported sexual offending (aged 18-35), the findings indicated that males reported significantly higher levels of general, penetrative-only, nonpenetrative-plus-penetrative sexual assault; and paraphilic interest in voyeurism, frotteurism, biastophilia, scatophilia, and hebephilia than females; while females reported a significantly higher level of transvestic fetishism than males. No significant difference was found in RSB between males and females. Logistic regressions found that the participants who possessed a higher level of RSB, particularly penetrative behaviors, and paraphilic interest in voyeurism and zoophilia were less likely to engage in a nonpenetrative-only sexual offense. Conversely, the participants who possessed higher levels of RSB, especially penetrative behaviors, and paraphilic interest in exhibitionism and zoophilia, were more likely to engage in nonpenetrative-plus-penetrative sexual assault. The implications for practice in areas such as public education and offender rehabilitation are discussed.
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  • 文章类型: Journal Article
    强迫性行为是一种现象,其特征是持续无法控制紧张,重复的性冲动或冲动,导致重复的性行为,导致明显的痛苦或个人损害,家族性,社会,教育,或职业领域的功能。尽管它对心理健康和生活质量有重大影响,人们对其内部结构以及这种现象是否因性别而异知之甚少,年龄组,和风险状况。通过考虑大量的在线样本(n=3186;68.3%的男性),年龄从14岁到64岁,通过网络分析对强迫性行为进行了探索。采用最先进的分析技术来研究强迫性行为的不同因素之间的关联模式,确定可能的节点社区,找出最中心的节点,并检测男性和女性之间的差异,在不同年龄段,以及处于发展为全面疾病的低风险和高风险的个体之间。分析表明,该网络的特征是三个社区,即后果,专注,和感知控制失调,最中心的节点与(感知的)冲动控制失调有关。在男性和女性之间以及不同年龄之间没有发现实质性差异。未能履行自己的承诺和责任是更重要的个人在高风险的发展一个全面的疾病比那些在低风险。
    Compulsive sexual behavior is a phenomenon characterized by a persistent failure to control intense, repetitive sexual impulses or urges, resulting in repetitive sexual behavior that causes marked distress or impairment in personal, familial, social, educational, or occupational areas of functioning. Despite its major impact on mental health and quality of life, little is known about its internal structure and whether this phenomenon differs across genders, age groups, and risk status. By considering a large online sample (n = 3186; 68.3% males), ranging from 14 to 64 years old, compulsive sexual behavior was explored by means of network analysis. State-of-the-art analytical techniques were adopted to investigate the pattern of association among the different elements of compulsive sexual behavior, identify possible communities of nodes, pinpoint the most central nodes, and detect differences between males and females, among different age groups, as well as between individuals at low and high risk of developing a full-blown disorder. The analyses revealed that the network was characterized by three communities, namely Consequence, Preoccupation, and Perceived Dyscontrol, and that the most central node was related to (perceived) impulse dyscontrol. No substantial differences were found between males and females and across age. Failing to meet one\'s own commitments and responsibilities was more central in individuals at high risk of developing a full-blown disorder than in those at low risk.
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  • 文章类型: Journal Article
    尽管有许多理论观点,目前还不清楚个人如何发展和维持亲热兴趣(例如,对儿童的性吸引力,对非自愿暴力的兴趣)。从这些观点中也不清楚为什么许多亲热的利益,尤其是许多亲缘性疾病和亲缘性疾病,男性比女性更常见。影响男性较高的亲线关系率的一个可能因素是焦虑,因为焦虑可以增强男性的性唤起。我们推测,当非典型性刺激反复产生焦虑感时,性交兴趣可能会发展,当焦虑反复增强性欲时,加强对非典型刺激的性反应。因此,有亲热兴趣的男性容易患焦虑症,因为焦虑症会促进假设的发育过程。我们对1048名连续患者(保留944名男性患者进行分析)进行了回顾性文件审查,这些患者转诊到精神病医院的门诊性行为诊所,以调查亲缘关系与焦虑之间的联系。与没有亲热的男性患者相比,亲热的男性患者被诊断出患有焦虑症的几率要高1.64,但他们也有许多其他类型疾病的发病率升高。因此,在这个样本中,似乎没有亲热和焦虑之间的具体联系。男性亲缘关系与心理障碍之间的一般联系的发现为研究男性亲缘关系的发展起源和后果开辟了新途径。
    Despite a multitude of theoretical views, it is still unclear how individuals develop and sustain paraphilic interests (e.g., sexual attraction to children, interest in non-consensual violence). It is also not clear from these views why many paraphilic interests, and especially many paraphilias and paraphilic disorders, are much more common in men than in women. One possible factor affecting male\'s higher rate of paraphilias is anxiety, because anxiety can potentiate sexual arousal in men. We speculated that paraphilic interests could develop when feelings of anxiety are recurrently generated by atypical sexual stimuli, and when that anxiety repeatedly potentiates sexual arousal, reinforcing sexual response to atypical stimuli. It follows that men with paraphilic interests are susceptible to anxiety disorders, because an anxiety disorder would facilitate the hypothesized developmental process. We conducted a retrospective file review of 1048 consecutive patients (944 male patients retained for analysis) referred to an outpatient sexual behavior clinic at a psychiatric hospital to investigate the link between paraphilias and anxiety. Male patients with a paraphilia had 1.64 greater odds than male patients without a paraphilia of having been diagnosed with an anxiety disorder, but they also had elevated rates of many other types of disorders. Therefore, there does not seem to be a specific link between paraphilias and anxiety in this sample. The discovery of a general link between the paraphilias and psychological disorders in men opens new avenues for studying the developmental origins and consequences of male paraphilic interests.
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  • 文章类型: Journal Article
    最近,强迫性行为障碍(CSBD)作为一种新的冲动控制障碍被纳入ICD-11。虽然这确实改善了CSBD的诊断,这种疾病的潜在大脑机制仍然知之甚少。需要更好地描述大脑功能缺陷。
    在这里,我们研究了一组CSBD患者与一组健康对照(HC)的静息状态脑功能连接(fc)模式。
    使用名为CONN功能连接工具箱的MATLAB工具箱来研究大脑连接的模式。fc与CSBD症状的严重程度和其他心理特征之间的相关性,用问卷评估,进行了检查。
    我们收集了81名异性恋男性的静息态功能磁共振成像数据:52名CSBD患者和29名HC患者。
    我们发现左额下回和右颞叶之间的fc增加,左右脑岛,右补充运动皮层(SMA),右顶骨盖,也在左缘上回和右平坦部之间,当比较CSBD和HC时,左眶额叶皮层和左岛之间。在左颞中回和双侧脑岛和右顶叶之间观察到fc降低。评估CSBD症状的心理问卷与静息状态功能连通性之间没有显着相关性。
    我们的研究结果扩展了区分CSBD和HC的脑机制的知识。
    该研究是第一个大样本研究,显示了5种不同的功能性脑网络区分CSBD患者和HC。然而,样本仅限于异性恋男性,在未来的研究样本和纵向研究需要更大的多样性。此外,本研究检查了感兴趣区域(ROI)水平的功能连通性。未来的研究可以通过检查体素水平的功能连通性来验证这些结果。
    确定的功能性脑网络将CSBD与HC区分开来,并为作为CSBD症状的潜在机制的激励致敏提供了一些支持。心理评估之间的相关性(即,CSBD的严重性,抑郁和焦虑症状,冲动和强迫性水平)和静息状态功能连通性需要进一步检查。DrapsM,AdamusS,WierzbaM,etal.强迫性行为障碍的功能连接-异性恋男性的文献和研究的系统评价。JSexMed2022;19:1463-1471。
    Compulsive Sexual Behavior Disorder (CSBD) was recently included in ICD-11 as a new impulse control disorder. While this certainly improved the diagnosis of CSBD, the underlying brain mechanisms of the disorder are still poorly understood. Better description of brain functional deficits is required.
    Here we investigate patterns of resting-state brain functional connectivity (fc) in a group of CSBD patients compared to a group of healthy controls (HC).
    A MATLAB toolbox named CONN functional connectivity toolbox was employed to study patterns of brain connectivity. Also correlation between fc and severity of CSBD symptoms and other psychological characteristics, assessed with questionnaires, were examined.
    We collected resting-state functional magnetic resonance imaging data from 81 heterosexual males: 52 CSBD patients and 29 HC.
    We found increased fc between left inferior frontal gyrus and right planum temporale and polare, right and left insula, right Supplementary Motor Cortex (SMA), right parietal operculum, and also between left supramarginal gyrus and right planum polare, and between left orbitofrontal cortex and left insula when compared CSBD and HC. The decreased fc was observed between left middle temporal gyrus and bilateral insula and right parietal operculum. No significant correlations between psychological questionnaires assessing CSBD symptoms and resting-state functional connectivity were observed.
    Results from our study extend the knowledge of brain mechanisms differentiating CSBD from HC.
    The study was the first large sample study showing 5 distinct functional brain networks differentiating CSBD patients and HC. However, the sample was limited only to heterosexual men, in the future a greater diversity in studied sample and longitudinal studies are needed. Also, the present study examined functional connectivity at the level of regions of interest (ROIs). Future studies could verify these results by examining functional connectivity at the voxel level.
    The identified functional brain networks differentiate CSBD from HC and provide some support for incentive sensitization as mechanism underlying CSBD symptoms. The correlation between psychological assessment (ie, severity of CSBD, depression and anxiety symptoms, level of impulsivity and compulsivity) and resting-state functional connectivity need further examination. Draps M, Adamus S, Wierzba M, et al. Functional Connectivity in Compulsive Sexual Behavior Disorder - Systematic Review of Literature and Study on Heterosexual Males. J Sex Med 2022;19:1463-1471.
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  • 文章类型: Journal Article
    强迫性行为(CSB)与非典型性兴趣之间的联系难以捉摸。本研究旨在对这两个方面之间的关系提供初步见解。研究样本包括61名自我认同的直男。CSB是通过评估CSB症状的综合自我报告指数来测量的,而性兴趣-非典型和正常嗜性-通过阴茎体积描记术客观评估。CSB指数很小,与对不同性刺激的更大性反应无显著相关性(一般性反应=.127[95%CI:-.137,.384])。就整体性兴趣而言,CSB指数的分数增加很小,与对年轻性刺激的更高偏好(r=-.098[95%CI:-.499,.215])和说服性(r=.10[95%CI:-.168,.316])无显著相关性。最后,CSB与性反应具有中等相关性,当呈现“女性幼儿胁迫”的刺激时(r=.27[95%CI:-.083,.544])。我们得出的结论是,我们的发现不支持以下假设:CSB与性刺激中的唤醒能力增加显着相关。研究结果还表明,CSB可能是,在很小的程度上,倾向于体验对儿童的性吸引力。鉴于这项研究的初步性质,这些结论值得进一步研究。还考虑了与CSB特定成分有关的研究结果的替代解释,这些成分可能与典型和非典型的性兴趣有关。
    The link between Compulsive Sexual Behavior (CSB) and atypical sexual interests is elusive. This study aimed to provide preliminary insights into the relationship between both aspects. The study sample comprised 61 self-identified straight men. CSB was measured through a composite self-report index assessing symptoms of CSB, whereas sexual interests -atypical and normophilic- were assessed objectively through penile plethysmography. The CSB index had small, non-significant correlation with greater sexual response to different sexual stimuli (rgeneral sexual responsiveness=.127 [95% CI: -.137, .384]). In terms of overall sexual interest, increased scores on the CSB index had small, non-significant correlation with a higher preference for younger sexual stimuli (r = -.098 [95% CI: -.499, .215]) and persuasive sex (r = .10 [95% CI: -.168, .316]). Finally, CSB had a moderate correlation with sexual response when presented with stimuli depicting \"female toddler coercive\" (r = .27 [95% CI: -.083, .544]). We conclude that our findings do not support the hypotheses that CSB is significantly related to an increased arousability across sexual stimuli. The study findings also suggest that CSB may be, to a small degree, predisposed to experience sexual attraction toward children. Given the preliminary nature of the study, these conclusions warrant further research. Alternative explanations for the study findings related to the particular components of CSB that may be related to typical and atypical sexual interests are also considered.
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  • 文章类型: Case Reports
    UNASSIGNED:自体性死亡被定义为当使用某种类型的设备来增强性刺激并导致意外死亡时发生的意外死亡。我们介绍了一名23岁男子在浴室中死亡的非典型自交死亡案例。一根电线,一端有标准的墙壁插头,另一端有裸露的电线扭成环,在他身体附近的地板上。每个乳头上都有轻微的黑色烧伤。插座由接地故障电路中断器保护,该中断器被证明处于工作状态。电气顾问得出的结论是,死因不可能是触电。接地故障电路断续器通过检测电路内的电流差异来工作。如果发生接地故障,电路断开以防止致命的触电。在目前的情况下,接地故障电路断路器没有关闭,因为死者已经将自己与电路并联。这个,与其他场景的发现,表明这是一个非典型的自体死亡病例。窒息以外的自体死亡很少见。此案用于说明通过电死造成的非典型自交死亡的情况。
    UNASSIGNED: Autoerotic death is defined as an accidental death that occurs when some type of apparatus is used to enhance sexual stimulation and causes an unintended death. We present the case of an atypical autoerotic death of a 23-year-old man found deceased in a bathroom. An electrical cord with a standard wall plug on one end and exposed wires twisted into loops on the other end was on the floor near his body. Minute black burns were present on each nipple. The outlet was protected by a ground fault circuit interrupter that was demonstrated to be in working order. An electrical consultant concluded that the cause of death could not be electrocution. Ground fault circuit interrupters work by detecting differences in current within a circuit. If a ground fault occurs, the circuit is broken to prevent a fatal electrocution. In the present case, the ground fault circuit interrupter did not shut off because the decedent had wired himself in parallel with the circuit. This, with the other scene findings, indicated this to be a case of atypical autoerotic death. Autoerotic deaths by means other than asphyxiation are rare. This case serves to illustrate the circumstances of an atypical autoerotic death by means of electrocution.
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  • 文章类型: Journal Article
    Guidelines suggest treating men with paraphilic disorder with androgen-deprivation therapy (ADT). However, little evidence is available about the long-term impact on bone loss and how to manage this adverse event.
    The aim of this study is to assess the impact of ADT on bone mineral density (BMD) in men treated for paraphilic disorder with the androgen receptor blocker cyproterone acetate (CPA) and/or GnRH agonist triptoreline (GnRHa) and to evaluate the effect of treatment with bisphosphonates.
    Baseline and follow-up dual-energy X-ray absorptiometry scan (DXA-scan) data (lumbar and femoral T-scores) were retrospectively extracted from electronic medical files of paraphilic men who received CPA and/or GnRHa.
    A total of 53 patients with a mean age of 39.1 years (range 17.5-74.6) were included. Lumbar (-0.39 ± 0.17, Mean ± SEM, p = 0.046), femoral neck (-0.34 ± 0.09, p = 0.002) and total femur (-0.33 ± 0.12, p = 0.014) T-scores decreased significantly in the CPA-only group (n = 13) during a mean follow-up of 6.0 ± 5.3 years. In the GnRHa group (n = 29), T-scores at all sites decreased significantly over 6.6 ± 4.4 years (lumbar: -0.55 ± 0.12, p < 0.001, femoral neck: -0.53 ± 0.09, total femur: -0.44 ± 0.09, p < 0.001). In the group, who received bisphosphonates (n = 11), no significant T-score change was observed (lumbar: -0.25 ± 0.14, p = 0.106, femoral neck -0.15 ± 0.17, p = 0.402, total femur -0.25 ± 0.14, p = 0.106) during 5.0 ± 2.8 years of follow-up.
    Following a mean duration of 6 years of ADT, we observed a significant decline in BMD of approximately half a standard deviation in T-score at lumbar and femoral site. Although the number of patients who received bisphosphonates was limited, this treatment seems to have a positive stabilizing effect on bone density.
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