最近,强迫性行为障碍(CSBD)作为一种新的冲动控制障碍被纳入ICD-11。虽然这确实改善了CSBD的诊断,这种疾病的潜在大脑机制仍然知之甚少。需要更好地描述大脑功能缺陷。
在这里,我们研究了一组CSBD患者与一组健康对照(HC)的静息状态脑功能连接(fc)模式。
使用名为CONN功能连接工具箱的MATLAB工具箱来研究大脑连接的模式。fc与CSBD症状的严重程度和其他心理特征之间的相关性,用问卷评估,进行了检查。
我们收集了81名异性恋男性的静息态功能磁共振成像数据:52名CSBD患者和29名HC患者。
我们发现左额下回和右颞叶之间的fc增加,左右脑岛,右补充运动皮层(SMA),右顶骨盖,也在左缘上回和右平坦部之间,当比较CSBD和HC时,左眶额叶皮层和左岛之间。在左颞中回和双侧脑岛和右顶叶之间观察到fc降低。评估CSBD症状的心理问卷与静息状态功能连通性之间没有显着相关性。
我们的研究结果扩展了区分CSBD和HC的脑机制的知识。
该研究是第一个大样本研究,显示了5种不同的功能性脑网络区分CSBD患者和HC。然而,样本仅限于异性恋男性,在未来的研究样本和纵向研究需要更大的多样性。此外,本研究检查了感兴趣区域(ROI)水平的功能连通性。未来的研究可以通过检查体素水平的功能连通性来验证这些结果。
确定的功能性脑网络将CSBD与HC区分开来,并为作为CSBD症状的潜在机制的激励致敏提供了一些支持。心理评估之间的相关性(即,CSBD的严重性,抑郁和焦虑症状,冲动和强迫性水平)和静息状态功能连通性需要进一步检查。DrapsM,AdamusS,WierzbaM,etal.强迫性行为障碍的功能连接-异性恋男性的文献和研究的系统评价。JSexMed2022;19:1463-1471。
Compulsive Sexual Behavior Disorder (CSBD) was recently included in ICD-11 as a new impulse control disorder. While this certainly improved the diagnosis of CSBD, the underlying brain mechanisms of the disorder are still poorly understood. Better description of brain functional deficits is required.
Here we investigate patterns of resting-state brain functional connectivity (fc) in a group of CSBD patients compared to a group of healthy controls (HC).
A MATLAB toolbox named CONN functional connectivity toolbox was employed to
study patterns of brain connectivity. Also correlation between fc and severity of CSBD symptoms and other psychological characteristics, assessed with questionnaires, were examined.
We collected resting-state functional magnetic resonance imaging data from 81 heterosexual males: 52 CSBD patients and 29 HC.
We found increased fc between left inferior frontal gyrus and right planum temporale and polare, right and left insula, right Supplementary Motor Cortex (SMA), right parietal operculum, and also between left supramarginal gyrus and right planum polare, and between left orbitofrontal cortex and left insula when compared CSBD and HC. The decreased fc was observed between left middle temporal gyrus and bilateral insula and right parietal operculum. No significant correlations between psychological questionnaires assessing CSBD symptoms and resting-state functional connectivity were observed.
Results from our
study extend the knowledge of brain mechanisms differentiating CSBD from HC.
The
study was the first large sample
study showing 5 distinct functional brain networks differentiating CSBD patients and HC. However, the sample was limited only to heterosexual men, in the future a greater diversity in studied sample and longitudinal studies are needed. Also, the present
study examined functional connectivity at the level of regions of interest (ROIs). Future studies could verify these results by examining functional connectivity at the voxel level.
The identified functional brain networks differentiate CSBD from HC and provide some support for incentive sensitization as mechanism underlying CSBD symptoms. The correlation between psychological assessment (ie, severity of CSBD, depression and anxiety symptoms, level of impulsivity and compulsivity) and resting-state functional connectivity need further examination. Draps M, Adamus S, Wierzba M, et al. Functional Connectivity in Compulsive Sexual Behavior Disorder - Systematic Review of Literature and
Study on Heterosexual Males. J Sex Med 2022;19:1463-1471.