背景:随着癌症治疗的不断进步,多内脏肿瘤胰腺切除术对发病率的影响的综合分析,死亡率,目前缺乏长期生存。
目的:本手稿提出了系统综述和荟萃分析的方案,旨在总结有关跨不同肿瘤实体的多内脏肿瘤胰腺切除结果的现有证据。
方法:我们将对PubMed或MEDLINE进行系统搜索,Embase,科克伦图书馆,CINAHL,和ClinicalTrials.gov数据库严格按照PRISMA(系统评价和荟萃分析的首选报告项目)指南。预定义的结果包括术后死亡率,术后发病率,总体和无病生存率(1至5年生存率),宏观完全(R0)切除的比例(根据皇家病理学家学院的定义),住院时间(天),再手术率(%),术后并发症(根据Clavien-Dindo分类涵盖所有并发症),以及胰瘘,胰腺切除术后出血,和胃排空延迟(均根据国际胰腺手术研究组的定义)。
结果:系统数据库搜索将于2024年7月开始。荟萃分析预计于2024年12月完成。在完成之前,文献检索将检查必须在工作背景下考虑的新出版物。
结论:即将到来的调查结果将提供可行性的最新概述,安全,以及跨不同肿瘤实体的多内脏胰腺切除术的肿瘤学疗效。这些数据将成为医疗保健专业人员和患者做出明智的临床决策的宝贵资源。
背景:PROSPEROCRD42023437858;https://tinyurl.com/bde5xmfw。
■PRR1-10.2196/54089。
BACKGROUND: With the continuous advancement of cancer treatments, a comprehensive analysis of the impact of multivisceral oncological pancreatic resections on morbidity, mortality, and long-term survival is currently lacking.
OBJECTIVE: This manuscript presents the protocol for a systematic
review and meta-analysis designed to summarize the existing evidence concerning the outcomes of multivisceral oncological pancreatic resections across diverse tumor entities.
METHODS: We will conduct a systematic search of the PubMed or MEDLINE, Embase, Cochrane Library, CINAHL, and ClinicalTrials.gov databases in strict accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The predefined outcomes encompass postoperative mortality, postoperative morbidity, overall and disease-free survival (1- to 5-year survival rates), the proportion of macroscopically complete (R0) resections (according to the Royal College of Pathologists definition), duration of hospital stay (in days), reoperation rate (%), postoperative complications (covering all complications according to the Clavien-Dindo classification), as well as pancreatic fistula, postpancreatectomy hemorrhage, and delayed gastric emptying (all according to the definitions of the International Study Group of Pancreas Surgery).
RESULTS: Systematic database searches will begin in July 2024. The completion of the meta-analysis is anticipated by December 2024. Before completion, the literature search will be checked for new publications that must be considered in the context of the work.
CONCLUSIONS: The forthcoming findings will provide an up-to-date overview of the feasibility, safety, and oncological efficacy of multivisceral pancreatic resections across diverse tumor entities. This data will serve as a valuable resource for health care professionals and patients to make well-informed clinical decisions.
BACKGROUND: PROSPERO CRD42023437858; https://tinyurl.com/bde5xmfw.
UNASSIGNED: PRR1-10.2196/54089.