晚期胰腺癌在全球范围内预后不良。患者常出现胰腺外分泌功能不全,导致吸收不良。本系统文献综述探讨胰酶替代疗法(PERT)对晚期胰腺癌患者的影响。数据源包括MEDLINE、CINAHL,Embase,科克伦(中部),心理信息,和JoannaBriggsInstitute从成立到2022年1月14日的数据库,并在GoogleScholar上检查参考列表。使用叙事综合,因为符合条件的研究可能是异质的,难以比较。这种综合方法使用4个步骤:理论发展,初步合成,探索关系,并评估综合的稳健性。四个主题来自分析研究结果,包括PERT教育,PERT的功效,病人的经验,缺乏对酶替代的认识。纳入的研究没有使用经过验证的工具或标准化的测量,这使得很难比较或得出结论。胰腺酶替代疗法显示出改善症状的潜力,营养,减肥,和生存,但具有标准化结局的高质量研究尚未完成.需要对患者和健康专业人员进行教育,因为似乎普遍缺乏对PERT在胰腺癌中使用的认识。系统评价注册:PROSPERO2020CRD42020195986。
Advanced pancreatic cancer has a poor prognosis globally. Patients often develop pancreatic exocrine insufficiency leading to malabsorption. This systematic literature
review explores the impact of pancreatic enzyme replacement therapy (PERT) on patients with advanced pancreatic cancer. Data sources include MEDLINE, CINAHL, Embase, Cochrane (CENTRAL), PsychINFO, and Joanna Briggs Institute databases from inception to January 14, 2022, with reference list checking on Google Scholar. Narrative synthesis was used as the eligible studies were likely to be heterogeneous and hard to compare. This synthesis approach uses 4 steps: theory development, preliminary synthesis, exploration of relationships, and assessment of the robustness of the synthesis. Four themes arose from analyzing the study outcomes including PERT education, efficacy of PERT, the patient experience, and lack of awareness regarding enzyme replacement. The included studies did not use validated tools or standardized measurements, which made it difficult to compare or draw conclusions. Pancreatic enzyme replacement therapy shows the potential to improve symptoms, nutrition, weight loss, and survival, but high-quality studies with standardized outcomes have not been completed. Patient and health professional education is required because there seems to be a general lack of awareness about the use of PERT in pancreatic cancer.Systematic
Review Registration: PROSPERO 2020 CRD42020195986.