各种肝脏疾病对人类构成巨大威胁。虽然这些肝脏疾病的病因相当多样,它们具有相似的病理表型和分子机制,如氧化应激,脂质和葡萄糖代谢紊乱,肝枯否细胞(KC)促炎极化和炎症,胰岛素抵抗,和肝星状细胞(HSC)的激活和增殖。过氧化物酶体增殖物激活受体β/δ(PPARβ/δ)在各种类型的肝细胞中表达,在KC和HSC中的表达相对较高。越来越多的证据揭示了PPARβ/δ的多功能功能,如控制脂质稳态,抑制炎症,调节葡萄糖代谢,恢复胰岛素敏感性,提示PPARβ/δ可能是各种肝病的潜在分子药物靶点。本文旨在提供一个简洁的结构回顾,PPARβ/δ在肝脏中的表达模式、生物学功能及其在多种肝脏疾病中的作用,并讨论潜在的未来研究前景。
Various liver diseases pose great threats to humans. Although the etiologies of these liver diseases are quite diverse, they share similar pathologic phenotypes and molecular mechanisms such as oxidative stress, lipid and glucose metabolism disturbance, hepatic Kupffer cell (KC) proinflammatory polarization and inflammation, insulin resistance, and hepatic stellate cell (HSC) activation and proliferation. Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is expressed in various types of liver cells with relatively higher expression in KCs and HSCs. Accumulating evidence has revealed the versatile functions of PPARβ/δ such as controlling lipid homeostasis, inhibiting inflammation, regulating glucose metabolism, and restoring insulin sensitivity, suggesting that PPARβ/δ may serve as a potential molecular drug target for various liver diseases. This article aims to provide a concise
review of the structure, expression pattern and biological functions of PPARβ/δ in the liver and its roles in various liver diseases, and to discuss potential future research perspectives.